Influence of MRI abnormality in skull base bone on prognosis of nasopharyngeal carcinoma

Lu, Jicun; Wei, Qing; Zhang, Yiqin; Li, Feng

doi:10.1016/j.canrad.2004.04.005

Cited by 13 publications

(12 citation statements)

References 9 publications

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“…Findings of skull base invasion were considered positive in cases in which the skull base had signals similar to those of the adjacent tumor on all pre-and postcontrast T1-weighted images in the cortical bone and bone marrow space on the MR image (low signal intensity on a T1-weighted image and contrast enhancement on the postcontrast T1-weighted image with fat suppression). 8,9,[17][18][19][20][21] We performed evaluations mainly on the basis of the precontrast 3D T1-weighted Dixon in-phase image and the postcontrast 3D T1-weighted Dixon water image. Other sequences were also used for identifying tumor location.…”

Section: Mr Imaging and Ct Diagnostic Criteria For Skull Base Invasionmentioning

confidence: 99%

Bone Subtraction Iodine Imaging Using Area Detector CT for Evaluation of Skull Base Invasion by Nasopharyngeal Carcinoma

Hiyama

Kuno

Koike

et al. 2018

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE: Conventional CT has generally lower detectability of bone marrow invasion than MR imaging due to lower tissue contrast. The purpose of this study was to compare the diagnostic performance of conventional CT alone or in combination with bone subtraction iodine imaging using area detector CT for the evaluation of skull base invasion in patients with nasopharyngeal carcinoma. MATERIALS AND METHODS: Forty-four consecutive patients who underwent contrast-enhanced CT using 320-row area detector CT and contrast-enhanced MR imaging for nasopharyngeal carcinoma staging between April 2012 and November 2017 were enrolled in this retrospective study. Bone subtraction iodine images were generated by subtracting pre-and postcontrast volume scans using a highresolution deformable registration algorithm. Two blinded observers evaluated skull base invasion at multiple sites (sphenoid body, clivus, bilateral base of the pterygoid process, and petrous bone) using conventional CT images alone or in combination with bone subtraction iodine images. Examination of MR and CT images by an experienced neuroradiologist was the reference standard for evaluating sensitivity, specificity, and area under the receiver operating characteristic curve. RESULTS: Twenty-six patients (59%) showed skull base invasion at 84 sites on the reference standard. Conventional CT plus bone subtraction iodine images showed higher sensitivity (92.9% versus 78.6%, P ϭ .02) and specificity (95.6% versus 86.1%, P ϭ .01) than conventional CT images alone for evaluating skull base invasion. The area under the receiver operating characteristic curve for conventional CT plus bone subtraction iodine (0.98) was significantly larger (P Ͻ .001) than the area under the receiver operating characteristic curve for conventional CT alone (0.90). CONCLUSIONS: Conventional CT plus bone subtraction iodine performs more closely to the accuracy of combining CT and MR imaging compared with conventional CT alone. ABBREVIATIONS: AUC ϭ area under the receiver operating characteristic curve; BSI ϭ bone subtraction iodine; CCT ϭ conventional CT; NPC ϭ nasopharyngeal carcinoma N asopharyngeal carcinoma (NPC), arising from the epithelial lining of the nasopharynx, has a propensity to invade the skull base just above the nasopharynx. Skull base invasion indicates a tumor stage of at least T3 according to the eighth edition of

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Section: Mr Imaging and Ct Diagnostic Criteria For Skull Base Invasionmentioning

confidence: 99%

Bone Subtraction Iodine Imaging Using Area Detector CT for Evaluation of Skull Base Invasion by Nasopharyngeal Carcinoma

Hiyama

Kuno

Koike

et al. 2018

AJNR Am J Neuroradiol

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“…However, recent research has indicated that some of the skull-base invasions on MRI had significantly better prognosis than the others. 12,13 Hence, further research on their prognostic value has been carried out with a large sample of MRI-detected skull-base abnormalities. In this study, we aimed to grade skull-base invasion on MRI and judge its prognosis precisely.…”

Section: Skull-base Invasion Of Nasopharyngeal Carcinomamentioning

confidence: 99%

“…Any disagreements were resolved by consensus. Skull-base invasion on MRI was established by the presence of low-intensity tissue in highsignal bone marrow on the T 1 -weighted image and Gd-DTPA enhancement of the abnormal tissue 8,13 MRI findings of skull-base invasion were assessed at the following sites: pterygoid process, base of sphenoid bone, petrous apex, clivus, foramen lacerum, pterygoid canal, great wing of sphenoid bone, pterygopalantine fossa, foramen rotundum, foramen ovale, jugular foramen, hypoglossal canal, internal acoustic meatus, and facial canal.…”

Section: Participants Betweenmentioning

confidence: 99%

Grading of MRI‐detected skull‐base invasion in nasopharyngeal carcinoma and its prognostic value

et al. 2010

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“…Skull base invasion is seen in up to 60% of NPC patients at diagnosis (King et al, 1999;Roh et al, 2004), with the most common sites of involvement being the clivus, pterygoid bones, body of the sphenoid bone, and apices of the petrous temporal bones (King & Bhatia, 2010). In addition, the number of sites involved within the skull base may have prognostic significance (Lu et al, 2004). Assessment of the skull base should focus on five key regions: clivus, right pterygoid base, left pterygoid base, right petrous apex, and left petrous apex (King & Bhatia, 2010).…”

Section: T3 Npcmentioning

confidence: 99%

Imaging of Nasopharyngeal Carcinoma

Chan¹,

Bartlett²,

Sahgal³

et al. 2012

Carcinogenesis, Diagnosis, and Molecular Targeted Treatment for Nasopharyngeal Carcinoma

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Carcinogenesis, Diagnosis, and Molecular Targeted Treatment for Nasopharyngeal Carcinoma 96 increased risk (Ren & Chan, 1996). Other exposures implicated in NPC include cigarette smoking, other smoke, and occupational exposures including wood dust and industrial heat (Yu et al., 2010). 2. Epidemiology of NPC NPC is a rare malignancy that exhibits a distinct ethnic and geographic variation (Chang & Adami, 2006). While in most regions of the world, age standardized incidence rates for both males and females are <1 per 100,000 person-years (Chang & Adami, 2006; Chong, 2006)), higher rates are observed in a few well-defined populations. Studies have demonstrated intermediate incidence rates in several indigenous populations in Southeast Asia, the Arctic, and the Middle East/North Africa (ranging from 0.5 to 31.5 per 100,000 person-years in males and 0.1 to 11.8 person-years in females) (Chang & Adami, 2006; Parkin et al., 2002), and endemic rates in the natives of southern China reaching 20-30 per 100,000 person-years and 15-20 per 100,000 person-years amongst males and females, respectively, in the province of Guangdong (Ho, 1978; Yoshizaki et al., 2011). In addition, within geographic regions, a distinct ethnic variation also exists. For example, in the US, rates are highest amongst Chinese Americans, followed by Filipino Americans, Japanese Americans, Blacks, Hispanics, and finally Caucasians (Burt et al., 1992). Globally, there are more than 80,000 incident cases and 50,000 deaths annually due to NPC (Parkin et al., 2005). NPC shows a male predilection of 2-3:1 (Parkin et al., 2002). In low risk populations, incidence increases with age, while in high risk populations, incidence peaks in the 6 th decade of life and declines thereafter. NPC is rare in pediatric populations. Thus, the highest incidence rates are observed in middle-aged men (Chang & Adami, 2006).

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Influence of MRI abnormality in skull base bone on prognosis of nasopharyngeal carcinoma

Cited by 13 publications

References 9 publications

Bone Subtraction Iodine Imaging Using Area Detector CT for Evaluation of Skull Base Invasion by Nasopharyngeal Carcinoma

Bone Subtraction Iodine Imaging Using Area Detector CT for Evaluation of Skull Base Invasion by Nasopharyngeal Carcinoma

Grading of MRI‐detected skull‐base invasion in nasopharyngeal carcinoma and its prognostic value

Imaging of Nasopharyngeal Carcinoma

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