Influence of morphology on in vitro compatibility of bioactive glasses

Andrade, Ângela Leão; Delgado-Valerio, Patricia; Góes, Alfredo M.; Leite, Maria de Fátima; Domingues, Rosana Zacarias

doi:10.1016/j.jnoncrysol.2006.03.105

Cited by 34 publications

(19 citation statements)

References 28 publications

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“…28 Finally, the peaks at 935 and 1040 cm À1 are attributed to the stretch bond between Si and non-bridging (NBO) oxygen spectrum and imply the occurrence of crystallization in the gel-derived 45S5. 6,[28][29][30] As combeite possesses more NBO bonding due to its structure than amorphous 45S5 31 , the presence of said peaks show that most of Si-O groups contain at least one NBO, which confirms that combeite is present in the structure.…”

Section: (3) In Vitro Resultsmentioning

confidence: 86%

“…As the stretching P–O bond at 1100 cm −1 is superimposed on the Si–O stretching bonds corresponding to the biomaterial; it becomes difficult to discriminate them. Therefore, two P–O bending peaks at 560 and 604 cm −1 are the main peaks used for characterizing the HA layer . These two peaks are detectable after 3 d of immersion and become more intense with increasing immersion time for both powder types (Fig.…”

Section: Resultsmentioning

confidence: 93%

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Sol–Gel Synthesis of Bioactive Glass‐Ceramic 45S5 and its in vitro Dissolution and Mineralization Behavior

2013

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Amorphous bioactive glasses such as 45S5 have been successfully used in bone‐filling therapy in non‐load bearing biomedical applications for decades. In this study, we challenge the predilection to amorphous over crystalline ceramics by investigating the effect of synthesis route on surface texture, in vitro dissolution, and mineral formation on powders produced by sol–gel and glass melt‐casting methods. Many reports have indicated bulk crystalline bioactive glass‐ceramics to be less bioactive than their amorphous counterparts as measured by the onset time for mineral formation. Bioactive glass 45S5 was synthesized using the sol–gel method followed by heat treatment to produce a semi‐crystalline structure and was compared against commercially available amorphous melt‐cast 45S5 powder. Gel‐derived samples were stabilized at 700°C making more than 80% of the structure crystalline. Dissolution of 45S5 glass‐ceramic in powder form(particle diameter 12 μm) was studied by in vitro immersion in simulated body fluid solution for various periods of time. The immersed powders were then analyzed through X‐ray diffraction (XRD), Scanning electron microscopy (SEM), energy dispersive X‐ray analysis (EDS), Differential scanning calorimetry (DSC), and thermogravimetric analysis (DSC/TGA), and Fourier transform infrared spectroscopy (FTIR) to determine the onset time for surface mineralization, and were compared with the melt‐cast powder as a control. The rates of dissolution and onset time for mineral formation were similar for the gel‐derived powder as compared with the melt‐cast control; it is proposed that the higher surface area of the sol–gel powder overcame the penalty usually associated with lower dissolution rates of crystalline materials, implicating surface texture as a much more important determinant of dissolution and mineralization behavior than mere crystallinity.

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Section: (3) In Vitro Resultsmentioning

confidence: 86%

Section: Resultsmentioning

confidence: 93%

Sol–Gel Synthesis of Bioactive Glass‐Ceramic 45S5 and its in vitro Dissolution and Mineralization Behavior

2013

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“…Andrade et al has studied the in vitro bioactivity and biocompatibility of fiber and bulk bioactive glasses produced by sol-gel method. 24) They have reported that osteoblast viability decreased 60% in the presence of fiber glass and 20% in the presence of bulk glass when compared to control group. They have explained the poor cell viability by the morphology of the materials and fiber dimensions.…”

Section: Osteoblast Cell Culturementioning

confidence: 98%

Effect of CeO2 addition on crystallization behavior, bioactivity and biocompatibility of potassium mica and fluorapatite based glass ceramics

Akin

Göller

2009

J. Ceram. Soc. Japan

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The bone-bonding ability of a glass ceramic can be evaluated by using simulated body fluid (SBF). Furthermore, rat primary osteoblast cell culture is effective in collecting preliminary information for potential application of any material of organic or inorganic origin. In this study, the effect of CeO2 addition on crystallization behavior and bioactivity of potassium mica and fluorapatite based glass ceramics was investigated. Also an osteoblast cell culture model was utilized to investigate the effect of CeO2 addition on biocompatibility of potassium mica and fluorapatite based glass ceramics by using biological criteria such as cell viability, metabolic activity and nitric oxide production.

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“…After they showed the osteointegration potential of phosphocalcic glass composition, the next step was to study the possible antimicrobial, anti inflammatory and healing properties. That can be conferred by modification of chemical composition, thermal treatments, but especially by doping with different metals with such already known properties [1,2,3,4].…”

Section: Introductionmentioning

confidence: 99%

A Comparative Study on the Properties of Potentially Bioactive Glasses Obtained by Sol-Gel Technique and by Melting Mixtures of Oxides

Avram

Ungureanu

Angelescu

et al. 2017

Scientific Bulletin of Valahia University - Materials and Mechanics

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Influence of morphology on in vitro compatibility of bioactive glasses

Cited by 34 publications

References 28 publications

Sol–Gel Synthesis of Bioactive Glass‐Ceramic 45S5 and its in vitro Dissolution and Mineralization Behavior

Sol–Gel Synthesis of Bioactive Glass‐Ceramic 45S5 and its in vitro Dissolution and Mineralization Behavior

Effect of CeO2 addition on crystallization behavior, bioactivity and biocompatibility of potassium mica and fluorapatite based glass ceramics

A Comparative Study on the Properties of Potentially Bioactive Glasses Obtained by Sol-Gel Technique and by Melting Mixtures of Oxides

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