In diagnostic radiology, medical-grade monochrome displays are usually recommended because of their higher luminance. Standard color displays can be used as a less expensive alternative, but have a lower luminance. The aim of the present study was to compare image quality for these two types of displays. Images of a CDRAD contrast-detail phantom were read by four radiologists using a 2-megapixel (MP) color display (143 cd/m 2 maximum luminance) as well as 2-MP (295 cd/m 2 ) and 3-MP monochrome displays. Thirty lumbar spine radiographs were also read by four radiologists using the color and the 2-MP monochrome display in a visual grading analysis (VGA). Very small differences were found between the displays when reading the CDRAD images. The VGA scores were j0.28 for the color and j0.25 for the monochrome display (p=0.24; NS). It thus seems possible to use color displays in diagnostic radiology provided that grayscale adjustment is used.