Influence of molecular organization and interactions on drug release for an injectable polymer-lipid blend

Grant, Justin; Lee, Helen; Soo, Patrick Lim; Cho, Jaepyoung; Piquette-Miller, Micheline; Allen, Christine

doi:10.1016/j.ijpharm.2008.04.031

Cited by 20 publications

(12 citation statements)

References 35 publications

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“…Mean object area (m 2 ) a M1 Grant et al (2008) a Mean object areas represent the average area surrounded by colocalized WSC and ePC in the colocalization map (Fig. 3D).…”

Section: Blendmentioning

confidence: 99%

Chitosan–phospholipid blend for sustained and localized delivery of docetaxel to the peritoneal cavity

Zahedi

Souza

Piquette-Miller

et al. 2009

International Journal of Pharmaceutics

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“…Mean object area (m 2 ) a M1 Grant et al (2008) a Mean object areas represent the average area surrounded by colocalized WSC and ePC in the colocalization map (Fig. 3D).…”

Section: Blendmentioning

confidence: 99%

Chitosan–phospholipid blend for sustained and localized delivery of docetaxel to the peritoneal cavity

Zahedi

Souza

Piquette-Miller

et al. 2009

International Journal of Pharmaceutics

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“…For this purpose, injectable, fluid polymers that either gel in situ or possess high viscosity are being investigated as alternative approaches to the use of more conventional formulations such as microspheres, emulsions, and liposomes. [1][2][3][4][5][6][7][8][9][10] This interest is a result of advantages that include a relatively facile formulation approach coupled with retention at the injection site.…”

Section: Introductionmentioning

confidence: 99%

Low Viscosity Poly(trimethylene carbonate) for Localized Drug Delivery: Rheological Properties and in vivo Degradation

Timbart

Tse

Pang

et al. 2009

Macromolecular Bioscience

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The purpose of this study is to examine the potential of low-molecular-weight poly(trimethylene carbonate) for localized delivery for acid-sensitive drugs. Poly(trimethylene carbonate) of various molecular weights is prepared by ring-opening polymerization initiated by octan-1-ol and co-initiated/catalyzed by tin 2-ethylhexanoate. The resultant polymers are amorphous with low glass transition temperatures and viscosities at 37 degrees C that permit their injection through an 18(1\2) G 1.5'' needle. Their biocompatibility and the influence of the molecular weight on the rate of degradation are assessed in vivo through subcutaneous implantation in rats over 40 weeks. The polymers are well tolerated in vivo, and degrade in a fashion dependent on their initial molecular weight. For very low initial molecular weight (620 Da) and for high initial molecular weight (2,400 Da), polymer mass loss is a result of dissolution of the soluble low molecular chains from the bulk. This is contrasted by the results obtained for an intermediate initial molecular weight (1,600 Da), for which polymer mass loss is a result of both dissolution and enzymatic hydrolysis or oxidation as a result of reactive species secreted by activated macrophages at the implant surface.

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“…Covalent and ionic crosslinking of chitosan leads to the formation of hydrogels, which can work as a drug delivery system under pH-controlled conditions [97]. Chitosan derivatives can also be applied in various tissue engineering applications, namely, skin, bone, cartilage, liver, nerve, and blood vessel [98][99][100][101][102].…”

Section: New Materials Based On Blends Of Chitosan With Other Polymersmentioning

confidence: 99%

“…Collagen possesses several interesting properties that make it a good material for biomedical applications . Chitosan also possesses several interesting properties to be applied as a potential biomedical material [82,[84][85][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100][101][102]. Chitosan can be blended with synthetic and/or other natural polymers [10,[13][14][15]19,20,46,48,54,62,.…”

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confidence: 99%

Natural Polymers as Components of Blends for Biomedical Applications

Sionkowska¹

2013

Polymeric Biomaterials

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INTRODUCTIONThe biomedical sector requests more and more complex structures in attempts to fulfill the requirements of a multitude of different applications. For this reason, polymer scientists exploit existing compounds and also design new compounds with properties that can be considered as new materials for biomedical applications [1,2]. The applications of polymers are essential in surgery, for prosthetic systems, and in pharmacology, for drug formulation and controlled drug delivery. Polymeric biomaterials are usually used under complex, demanding conditions, and must fulfill stringent requirements relating to their chemical, biological, and physicomechanical properties. Therefore, there is an urgent need for new polymeric biomaterials that can satisfy the demanding performance requirements and standards required for these applications [3]. The development of innovative polymeric biomaterials can be an engine of innovation for new medical treatments and therapies. The existing knowledge clearly shows that the careful optimization of the chemical structure of polymers used in medical implants can result in better clinical outcomes for the implant recipients. Biodegradable polymers play a significant role in the preparation of polymeric materials for biomedical applications. They are preferred candidates for developing therapeutic devices such as temporary prostheses, three-dimensional porous structures as scaffolds for tissue engineering, and as controlled/sustained release drug delivery vehicles [4].At the end of the twentieth century, a new trend in the development of polymeric materials was observed [5]. Many scientific laboratories started to work with polymer blends as potential new materials for medicine (biomaterials), the food industry (biodegradable and photodegradable food packaging materials), and for the electronic industry (conducting polymers). Especially, new materials for biomedical applications based on the blends of two polymers were studied. Cell-based transplantation, CONTENTS

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Influence of molecular organization and interactions on drug release for an injectable polymer-lipid blend

Cited by 20 publications

References 35 publications

Chitosan–phospholipid blend for sustained and localized delivery of docetaxel to the peritoneal cavity

Chitosan–phospholipid blend for sustained and localized delivery of docetaxel to the peritoneal cavity

Low Viscosity Poly(trimethylene carbonate) for Localized Drug Delivery: Rheological Properties and in vivo Degradation

Natural Polymers as Components of Blends for Biomedical Applications

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