Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice

Kanclerz, A; Chapman, J. D.

doi:10.1016/0360-3016(88)90438-5

Cited by 10 publications

(4 citation statements)

References 21 publications

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“…The finding that amifostine inhibited metastatic development in the lungs of mice contrasts with that of an earlier study, which failed to demonstrate any effect of amifostine on this process in the Lewis lung carcinoma model 24. No effect was observed when amifostine was administered either as a single dose of 400 mg/kg, or in 10 daily doses of either 50, 100 or 200 mg/kg.…”

Section: Discussioncontrasting

confidence: 83%

“…However, unlike the present investigation, animals were exposed to amifostine only after the surgical removal of the primary tumor. Under that treatment protocol the potential effectiveness of amifostine as an antimetastatic agent was measured only on established disseminated disease, rather than on the metastatic processes that occur during tumor growth 24. The decision to begin amifostine treatment 24 hr after surgery may account for the lack of an effect that was reported in this earlier study.…”

Section: Discussionmentioning

confidence: 97%

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Inhibition of spontaneous metastases formation by amifostine

Grdina

Kataoka

Murley

et al. 2001

Intl Journal of Cancer

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Amifostine was investigated for its ability to inhibit spontaneous metastases formation using the well-characterized murine sarcoma, Sa-NH. Amifostine was administered intraperitoneally at a dose of 50 mg/kg every other day for 6 days to C3Hf/Kam mice until tumors reached an average size of 8 -8.5 mm in diameter. Amifostine was again administered immediately after surgical removal of the tumor-bearing limbs by amputation, and then once more 2 days later. Twenty-one days later, animals were evaluated for the presence of spontaneously developed pulmonary metastases. Nontumorbearing control animals were sham treated using the same dosing and surgery schedules. Treatment with amifostine appeared to slightly delay tumor growth, that is, 13 vs. 12 days for tumors to reach an average diameter of 8 mm. Amifostine reduced both the incidence of pulmonary metastases formed in experimental animals from 77% to 57% (p < 0.05), and their average number per animal from 12.8 ؎ 5.4 (SEM) to 2.9 ؎ 1.1 (SEM). The effect of amifostine exposure on serum levels of the angiogenesis inhibitor angiostatin was also determined using Western blot analysis. Consistent with the antimetastatic effect, exposure of animals to 50 mg/kg of amifostine resulted in a 4-fold enhanced serum level of angiostatin above control levels. This phenomenon occurred in tumor-bearing and nontumor-bearing animals. The effects of amifostine on matrix metalloproteinase (MMP) enzymatic activity was also determined using gelatin zymography. Conditioned growth medium collected from Sa-NH cells grown to confluency was exposed to various concentrations of SH, i.e.

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Section: Discussioncontrasting

confidence: 83%

Section: Discussionmentioning

confidence: 97%

Inhibition of spontaneous metastases formation by amifostine

Grdina

Kataoka

Murley

et al. 2001

Intl Journal of Cancer

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“…However, amifostine had little effect on the radiation-induced enhancement of cancer metastasis in these metastasis models. Based on previous reports, amifostine may inhibit spontaneous metastasis [7], promote lung metastases [8], or have little effect on radiation-induced tumor metastasis enhancement [9]; therefore, using amifostine to prevent cancer metastasis remains disputable. As nicaraven protects against radiation injury without serious side effects at protective doses [10,13,14,26], nicaraven is likely an appropriate radioprotective agent for cancer patients after radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…Amifostine has been clinically approved as a cytoprotective adjuvant to alleviate the side effects of radiotherapy, but its clinical application is limited by severe side effects [6]. Furthermore, it remains disputable whether amifostine reduces cancer metastasis [7][8][9]. Nicaraven, a powerful free radical scavenger, can protect normal tissues from ischemia-reperfusion injury [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment

et al. 2018

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Radiotherapy for cancer patients damages normal tissues, thereby inducing an inflammatory response and promoting cancer metastasis. We investigated whether nicaraven, a compound with radioprotective and anti-inflammatory properties, could attenuate radiation-induced cancer metastasis to the lungs of mice. Nicaraven and amifostine, another commercial radioprotective agent, had limited effects on both the radiosensitivity of Lewis lung carcinoma cells in vitro and radiation-induced tumor growth inhibition in vivo. Using experimental and spontaneous metastasis models, we confirmed that thorax irradiation with 5 Gy X-rays dramatically increased the number of tumors in the lungs. Interestingly, the number of tumors in the lungs was significantly reduced by administering nicaraven but not by administering amifostine daily after radiation exposure. Furthermore, nicaraven administration effectively inhibited CCL8 expression and macrophage recruitment in the lungs 1 day after thorax irradiation. Our data suggest that nicaraven attenuates radiation-induced lung metastasis, likely by regulating the inflammatory response after radiation exposure.

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Radiosensitizer

Rhomberg¹,

Dunst²

2006

Kompendium Internistische Onkologie

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Influence of misonidazole, SR-2508, RSU-1069 and WR-2721 on spontaneous metastases in C57BL mice

Cited by 10 publications

References 21 publications

Inhibition of spontaneous metastases formation by amifostine

Inhibition of spontaneous metastases formation by amifostine

Nicaraven reduces cancer metastasis to irradiated lungs by decreasing CCL8 and macrophage recruitment

Radiosensitizer

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