Influence of miR‑101 on proliferation of liver cancer cells through the MAPK/ERK signaling pathway

Meng, Xuan; Shi, Yong; Xiang, Xin; Li, Chonghui; Ge, Xinlan; Pan, Ke; Liang, Yurong

doi:10.3892/ol.2019.11210

Cited by 9 publications

(8 citation statements)

References 23 publications

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“…In the present study, the tumor suppressive role of miR-101 in liver cancer was shown, which signi cantly decreased the expression of miR-101 in liver cancer, which is consistent with the study of Xuan Meng et al (2020). According to the previous information and the con rmation of the observed changes in the expression pro le of microRNAs in tumor and non-tumor samples, it is suggested that they can be used as diagnostic or prognostic biomarkers (Fabris, Ceder et al 2016).…”

Section: Discussionsupporting

confidence: 91%

“…While other genes are associated with cancer progression, they are associated with overall poor clinical outcomes in HCC patients (Fabris, Ceder et al 2016). Therefore, the use of bioinformatics predictive tools and con rmation of the gene targets of microRNAs plays an important role in correct, fast and less expensive selection than experimental-laboratory methods (Meng, Shi et al 2020). Some of these tool's act as a complete atlas of information and include the experimental results of studies conducted in the past and bioinformatics prediction and provide data very close to real results.…”

Section: Discussionmentioning

confidence: 99%

“…One of the important markers that play a role in regulating important cellular processes (cellular growth, differentiation and cell survival) are miRNAs (Vasudevan 2012, Wen, Han et al 2015. Because miRNAs identify their target mRNAs in carcinogenesis with the role of suppressing tumors or oncogenes and act on them (Xu, Beckebaum et al 2014, Meng, Shi et al 2020).…”

Section: Introductionmentioning

confidence: 99%

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Bioinformatic role of MIR-101 on PTEN and Mcl1 target genes in liver cancer patients

Rahimi‐Farsi

Shahbazi

2023

Preprint

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One of the three causes of death in the world is liver cancer, which is common in today's society. One of the new methods in the treatment of liver cancer is the identification of new and less invasive biomarkers, among which microRNA can be mentioned. Therefore, in this study, the bioinformatic role of mir-101 on the target genes PTEN and Mcl1 in liver cancer was evaluated. Materials and methods: In this theoretical study, Target Scan, miR Base, DIANA Tool, miRanda, miRTarBase, miR Walk, miR path target genes and signaling pathway of miR-101 were investigated using bioinformatics databases. Then, GEO data was analyzed with R software to analyze miR-101. Finally, the biomarker role of miR-101 was analyzed with ROC diagram. Results: Investigations conducted using different databases as well as statistical methods using R software and graph prism provided a comprehensive analysis of miR-101-3p/5p and based on the analysis of the ROC diagram, the specificity of miR-101 was reported to be higher than 0.5. Also, investigations and target gene selection from different bioinformatics databases showed that PTEN genes with their tumor suppressive role and Mcl1 with their anti-apoptotic role in the TGF- β signaling pathway had dual behavior against each of the studied target genes. Finally, it inhibited metastasis in the signaling pathway of liver cancer, thus reducing the expression of microRNA in patients with liver cancer. Conclusion: According to the obtained results, miR-101 is a targeted therapy for the diagnosis, prognosis and treatment of HCC.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bioinformatic role of MIR-101 on PTEN and Mcl1 target genes in liver cancer patients

Rahimi‐Farsi

Shahbazi

2023

Preprint

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“…Compared with normal cells, cancer cells and tumor tissues usually evade apoptosis [ 17 ]. Moreover, compared with the levels in adjacent normal liver tissues, the ERK signaling pathway is in an abnormally active state of phosphorylation in liver cancer tissues [ 18 ]. Highly activated growth factors can activate tyrosine kinase and stimulate the ERK signaling pathway, leading to a cascade reaction and the activation of nuclear transcription factors, such as NF-κB, to promote the proliferation of hepatocellular carcinoma cells [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Bradykinin Receptor Inhibitors Inhibit Proliferation and Promote the Apoptosis of Hepatocellular Carcinoma Cells by Inhibiting the ERK Pathway

et al. 2021

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Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Studies have shown that bradykinin (BK) is highly expressed in liver cancer. We designed the novel BK receptor inhibitors J051-71 and J051-105, which reduced the viability of liver cancer cells and inhibited the formation of cancer cell colonies. J051-71 and J051-105 reduced cell proliferation and induced apoptosis in HepG2 and BEL-7402 cells, which may be due to the inhibition of the extracellular regulated protein kinase (ERK) signaling pathway. In addition, these BK receptor inhibitors reversed the cell proliferation induced by BK in HepG2 and BEL-7402 cells by downregulating B1 receptor expression. Inhibiting B1 receptor expression decreased the protein levels of p-ERK and reduced the malignant progression of HCC, providing a potential target for HCC therapy.

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“…In hepatocellular carcinoma, miR-101 is proven to specifically bind to vascular endothelial growth factor (VEGF) mRNA three prime untranslated region (3′-UTR) to decrease protein levels of VEGFA (one of the main isotypes of VEGF) [ 21 ] and inhibit VEGFR2 signaling pathway thereby impair the malignant behavior of HCC cells. MiR-101 could also inhibit the proliferation of liver cancer cells by targeting zinc finger protein 217 (ZNF217), mitogen-activated protein kinases (MAPK)/extracellular signal-regulated kinase (ERK) signaling pathways, and hepatocyte growth factor (HGF)/c-MET axis [ 22 , 23 , 24 ]. The expression level of miR-101 is decreased in liver cancer which loses the inhibition effect on the above target genes acting as on–off switches of particular mRNAs or by modulating the relationship between effector and target mRNAs.…”

Section: Mir-101 Regulates Cancer Growth Metastasis and Therapeutic R...mentioning

confidence: 99%

MiR-101: An Important Regulator of Gene Expression and Tumor Ecosystem

Liu

Yang

Gao

et al. 2022

Cancers

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MiRNAs are small single-stranded non-coding RNAs. MiRNA contributes to the transcriptional and post-transcriptional regulation of mRNA in different cell types, including mRNA transcription inhibition and mRNA decay and phenotypes via the effect of several essential oncogenic processes and tumor microenvironment. MiR-101 is a highly conserved miRNA that was found to alter the expression in various human cancers. MiR-101 has been reported to have tumor oncogenic and suppressive effects to regulate tumorigenesis and tumor progression. In this review, we summarize the new findings about the roles of miR-101 in cancers and the underlying mechanisms of targeting genes degradation and microenvironment regulation, which will improve biological understanding and design of novel therapeutics.

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Influence of miR‑101 on proliferation of liver cancer cells through the MAPK/ERK signaling pathway

Cited by 9 publications

References 23 publications

Bioinformatic role of MIR-101 on PTEN and Mcl1 target genes in liver cancer patients

Bioinformatic role of MIR-101 on PTEN and Mcl1 target genes in liver cancer patients

Novel Bradykinin Receptor Inhibitors Inhibit Proliferation and Promote the Apoptosis of Hepatocellular Carcinoma Cells by Inhibiting the ERK Pathway

MiR-101: An Important Regulator of Gene Expression and Tumor Ecosystem

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