Influence of Microcrystalline Collagen on Wound Healing I. Wound Closure of Normal Excised and Burn Excised Wounds of Rats, Rabbits, and Pigs

Abstract

During the past two decades, understanding of the general nature and control of the closely integrated process of wound healing has been expanded (1-4). The role of native collagen synthesized de novo in the process of healing cutaneous wounds has been referenced by many workers in the past decade 4 Murrell Farms; Fort Worth, TX. 5 Microcrystalline collagen wound pad ; Avicon, 6 Curity gauze sponges ; Kendall Hospital Products 7 3 M Co., Minneapolis, MN. Inc., Fort Worth, TX. Div. ; Chicago, IL. Sta-tite, Cheeseborough-Pond ; New York, New York.

Laboratory Studies of Collagen Wound Dressing (Cas)

“…Some papers have already been published about the used of collagen as artificial skin , (12)(13)(14). Up until now.…”

Tissue Engineering and Regenerative Repair in Wound Healing

“…Since collagen has similar properties and structure as the natural ECM, it is a reasonable scaffold material for regenerative therapies. 81 Collagen-based scaffolds have been tested in the repair of cartilage, 45,128,129 skin, 3,108 and bone. 63,117,146,147 There are currently several collagen-based devices on the market.…”

“…Promogram, BICOL, and Puraply are all collagen-based applications for wound protection, wound site support, ulcer protection, and tissue regeneration. 29,81,116 Unfortunately, the majority of these scaffolds are not comprised of the fetal Collagen I/III ratio and therefore are not ideally suited to reciprocate the fetal dermis and promote scarless wound healing.…”