Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention

Zhang, Sai-Long; Wang, Shu-Na; Miao, Chao‐Yu

doi:10.3389/fimmu.2017.01674

Cited by 114 publications

(78 citation statements)

References 163 publications

(168 reference statements)

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“…Additionally, fecal levels of several commensal bacteria, including Veillonella spp., E. coli, and Fusobacterium spp., were positively associated with inflammation biomarkers in the current study. All of those bacteria were considered as invasive [38][39][40], and high levels were reported previously in IBD patients [23,28,31,33,[41][42][43][44][45]. Changes in Prevotella spp.…”

Section: Discussionmentioning

confidence: 98%

Development of an Index Score for Intestinal Inflammation-Associated Dysbiosis Using Real-World Stool Test Results

et al. 2019

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Background Gut microbiota play an important role in human health. However, the application of gut microbiome in regular clinical practice is limited by interindividual variations and complexity of test results. Hypothesis It is possible to address interindividual variation by using large data-based exploratory-pattern analysis. Methods The current study was conducted using a large data set (n = 173,221) of nonselective incoming patients' test results from a stool test. The data set included assays for the detection of 24 selected commensal microorganisms and multiple biomarkers in feces. Patients were grouped based on their levels of inflammation biomarkers such as calprotectin, eosinophil protein X, and IgA. Group mean values of biomarkers and commensal microbes were used in an exploratory-pattern analysis for association from which an index score for intestinal inflammation-associated dysbiosis (IAD) was developed. The IAD score was evaluated in one questionnaire-based study (n = 7263) and one prospective case series study (n = 122) with patients of inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), and celiac disease. Results We identified a microbial profile strongly associated with fecal inflammation biomarkers. Developed on the pattern of the microbial profile, the IAD score demonstrated a strong association with fecal inflammation biomarkers and was significantly different between patients with IBD and those with IBS or celiac disease. Conclusion Using real-world data, we have developed a method to predict gut dysbiosis associated with different GI disease conditions. It may help clinicians simplify the process of interpreting gut microbial status and provide gut health assessment and treatment evaluation.

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Section: Discussionmentioning

confidence: 98%

Development of an Index Score for Intestinal Inflammation-Associated Dysbiosis Using Real-World Stool Test Results

et al. 2019

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“…3D , where we found phenotypes related to inflammation were driven by high-divergence genes. Furthermore, we find that Eubacterium rectale and B. ovatus , microbes that have higher abundance in humans and that have been previously associated with inflammatory bowel disease (Noor et al, 2010;Zhang et al, 2017) , upregulate the expression of CSF3 , which has been reported as upregulated in ulcerative colitis patients (de Lange & Barrett, 2015;Hotte et al, 2012) To investigate specific host gene-pathway interactions, we constructed a network of the most significant interactions between microbial pathways and high-divergence host genes as described above ( Fig 4E ; see Methods). We find that nine of these 17 host genes, including DUSP5 , CYR61 , NFKBIZ , PTGS2 , IL6 , CXCL8 , IL36G , IL1B , and IL36RN (all displayed at the top layer in Fig.…”

Section: Examples Of Several Microbes That Have Variable Abundance Acmentioning

confidence: 98%

Interspecies variation in hominid gut microbiota controls host gene regulation

Muehlbauer

Richards

Alazizi

et al. 2020

Preprint

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The gut microbiome exhibits extreme compositional variation between hominid hosts. However, it is unclear how this variation impacts host physiology, and whether this effect can be mediated through microbial regulation of host gene expression in interacting epithelial cells. Here, we characterized the transcriptional response of colonic epithelial cells in vitro to live microbial communities extracted from humans, chimpanzees, gorillas, and orangutans. We found most host genes exhibit a conserved response, whereby they respond similarly to the four hominid microbiomes, while some genes respond only to microbiomes from specific host species. Genes that exhibit such a divergent response are associated with relevant intestinal diseases in humans, such as inflammatory bowel disease and Crohn's disease. Lastly, we found that inflammation-associated microbial species regulate the expression of host genes previously associated with inflammatory bowel disease, suggesting health-related consequences for species-specific host-microbiome interactions across hominids.

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“…Gut microbiota is considered to be an critical factor in deriving ulcerative colitis (UC) [1,2,3], which is characterized by abnormal microbiota leading to disruption of ora balance, decreasing the complexity of the intestinal microbial ecosystem [4]. At the same time, UC is thought to be caused by an imbalance between intestinal microbiota and mucosal immunity [5].…”

Section: Introductionmentioning

confidence: 99%

ShenLing BaiZhu San alleviates Ulcerative Colitis in Rats by Regulating Gut Microbiota

Gu¹,

Zhou²,

Yao³

et al. 2020

Preprint

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Background: Recent studies have suggested that Shenling Baizhu San (SLBZS), an complementary and alternative medical therapy for ulcerative colitis (UC), alleviate clinic symptoms by the improvement of biochemical criteria and restoration of the intestinal barrier function. SLBZS as a famous Chinese herbal formula has been reportedly used to treat UC, of which mechanism is unknown. This study investigated the therapeutic effects of SLBZS on restoring the gut microbiota in a UC rat model. Methods: We proposed a 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced UC rat model to monitor the structural modulation of the gut microbiota. The test period was 10 days (observation for two days after modeling, treatment for 8 days by SLBZS). In this study, the level of inflammatory cytokines and activity of antioxidant enzymes in serum were ascertained by enzyme-linked immunosorbent assay (ELISA) and histological changes of colon were observed. Feces were collected for high-throughput sequencing of 16S rRNA gene. Results: SLBZS partly reduced the diversity of the gut microbiota, while the abundance of that is increased. Furthermore, at the genus level, the relative abundance of short chain fatty acids (SCFA) producing bacteria including Prevotella and Oscillospira increased, while the relative abundance of harmful bacteria including Desulfovibrio, and Bilophila decreased. Additionally, SLBZS could improve the lesions of colon and significantly reduce the expression of Interleukin-6 (IL-6) and Myeloperoxidase (MPO) and increase the activities of Superoxide dismutase (SOD) and Catalase (CAT) in rats serum. Conclusions: These results demonstrate that SLBZS may treat UC effectively by inhibiting inflammation, enhancing antioxidant capacity and regulating gut microbiota.

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Influence of Microbiota on Intestinal Immune System in Ulcerative Colitis and Its Intervention

Cited by 114 publications

References 163 publications

Development of an Index Score for Intestinal Inflammation-Associated Dysbiosis Using Real-World Stool Test Results

Development of an Index Score for Intestinal Inflammation-Associated Dysbiosis Using Real-World Stool Test Results

Interspecies variation in hominid gut microbiota controls host gene regulation

ShenLing BaiZhu San alleviates Ulcerative Colitis in Rats by Regulating Gut Microbiota

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