Influence of microbial flora on xylose absorption in rats and mice

Heneghan, James B.

doi:10.1152/ajplegacy.1963.205.3.417

Cited by 72 publications

(14 citation statements)

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“…D-xylose absorption tests for measuring small intestine dysfunction following virus infections have been reported in children (Mavromichalis et al, 1977), calves (Woode et al, 1978), mice (Heneghan, 1963), turkeys and broiler chickens (Goodwin et al, 1984;Goodwin et al, 1985). Our study using D-xylose test in the chickens inoculated with isolate 615 detected a statistically significant drop in intestinal absorption on day 7 pi.…”

Section: Discussionmentioning

confidence: 49%

Serological and pathogenic characterization of avian reoviruses isolated in Quebec

1991

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SUMMARYReoviruses were isolated from intestinal contents of broiler chickens from nine flocks in Quebec with malabsorption syndrome. Serum neutralization test demonstrated the existence of antigenic differences between the isolates and the reference vaccine strain. The isolated reoviruses were inoculated orally and into the foot pad in one-day-old chicks, resulting in a transient, but significant depression in body weight gains. Chickens infected with isolate 615, showed in addition to growth problems, clinical signs and tissue lesions similar to those observed in field cases. When isolate 615 was inoculated into SPF chicks at one day of age, intestinal absorption of D-xylose in infected chicks at 7 days post-infection was significantly lower (P <0.05) than for corresponding controls. This study suggests the implication of some reovirus isolates, such as 615 which was serologically distinct from the vaccine strain S1133, as infectious agents associated with pathological conditions other than viral arthritis.

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Section: Discussionmentioning

confidence: 49%

Serological and pathogenic characterization of avian reoviruses isolated in Quebec

1991

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“…For instance, xylose, which is absorbed from the intestinal lumen by both passive and carrier-facilitated means, is absorbed at approximately twice the rate in GF mice compared to CVz mice [8]. Therefore, it is possible that the absorption or permeability rate of DSS into the mucosa may differ between GF and CVz mice.…”

Section: Figmentioning

confidence: 99%

Dextran Sodium Sulfate-Induced Colitis in Germ-Free IQI/Jic Mice.

et al. 2001

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This study presents a histological examination of dextran sodium sulfate (DSS)-induced colitis in germ-free (GF) mice. A comparison of the pathology between GF and conventionalized mice (CVz) was made to determine the role that intestinal microflora play in DSS-induced colitis. To induce colitis, GF and CVz IQI/Jic mice were given either 5% or 1% DSS orally. Administration of 5% DSS, a common concentration used to induce colitis in mice, caused gross rectal bleeding and a marked decrease in hematocrit as early as day one in GF mice. These mice died on day three due to massive bleeding into the intestinal lumen. In contrast, CVz mice did not die during the seven-day experimental period. Histopathological examination three days after administration of 5% DSS did not reveal any colitis lesions in GF mice, but CVz mice had developed moderate colitis in the large intestine. Administration of a low concentration of DSS (1%), which only induces mild basal crypt loss in CVz mice, caused severe colitis in the distal colon in GF mice, and they died on day 14. These data suggest that intestinal microflora are not necessary for the induction of colitis. Furthermore, DSS may be highly toxic to GF mice, and when given at a concentration of 5% it causes massive bleeding into the intestinal lumen resulting in death prior to development of colitis.

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“…* (3979) BERNARD The absence of a viable flora in germfree animals leads to a number of deviations from the normal morphological and functional characteris tics of the gas trolintes tinal tract In germfree rats, mice, rabbits, and guinea pigs the cecum is enlarged ( 1 ) , while the wall of the small intestine is thinner and carries smaller villi with less absorptive surface ( 2). Permeability of the tract as expressed by passive absorption is greater in the germfree rat (3). Proteases and carbohydrases occur in higher concentrations (4,s).…”

Section: Oxidfation-reduction Potentials In Cecal Contents Of Germfrementioning

confidence: 99%

Oxidation-Reduction Potentials in Gecal Contents of Germfree and Conventional Rats.

Wostmann

Bruckner-Kardoss

1966

Experimental Biology and Medicine

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Influence of microbial flora on xylose absorption in rats and mice

Cited by 72 publications

References 0 publications

Serological and pathogenic characterization of avian reoviruses isolated in Quebec

Serological and pathogenic characterization of avian reoviruses isolated in Quebec

Dextran Sodium Sulfate-Induced Colitis in Germ-Free IQI/Jic Mice.

Oxidation-Reduction Potentials in Gecal Contents of Germfree and Conventional Rats.

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