Influence of methyl parathion on reproductive parameters in male rats

Joshi, S. C.; Mathur, Rati; Gajraj, Anita; Sharma, Tek Chand

doi:10.1016/s1382-6689(03)00043-7

Cited by 78 publications

(40 citation statements)

References 16 publications

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“…The observed reduction in weight of accessory sex organs may be due to a reduction in bioavailability of estrogenic and/or antiandrogenic activities of insecticides. The decreased testosterone level in the treated animals confirms the results of (Joshi et al, 2003).…”

Section: Discussionsupporting

confidence: 82%

Effect of Dimethoate (An Organophosphate Insecticide) on the Reproductive System and Fertility of Adult Male Rat

Ngoula¹

2014

American Journal of Pharmacology and Toxicology

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The pesticides are one of the most potentially harmful chemicals liberated in the environment in an unplanned manner. Dimethoate is widely used as a potent pesticide in many countries and has been shown to produce some adverse health effects. In the present study, we investigated the effect of dimethoate (an organophosphate insecticide) on the reproductive system and fertility of male rats and the possible mechanism underlining its action. Twenty four adult Wistar male rats were divided into 4 groups of 6 animals per group and force-fed with 0, 3.66, 5.50 and 11 mg kg −1 body weight of dimethoate for 90 days. At 80 days of treatment, each males was allows to mate with two primiparous cyclic females. The results showed a significant decrease (p<0.05) of body weight gain in rats gavaged with dimethoate compared to control. In addition, this insecticide at the doses of 3.66, 5.5 and 11 mg kg −1 caused a significant (p<0.05) increase of the relative weight of epididymis. Dimethoate at its highest dose caused a decrease in the relative weights of testes and ventral prostate. The doses 3.66, 5.50 and 11.00 mg kg −1 body weight of dimethoate caused a significant decrease (p<0.05) of the sperm concentration and motility. The level of protein and cholesterol in the serum and testes as well as the activity of prostatic acid phosphatase decreased significantly (p<0.05) in rats treated with dimethoate compared to control. Fertility, gestation and parturition indices as well as the litter size decreased significantly in animals treated with 5.50 and 11.00 mg kg −1 body weight of dimethoate compared to control. The testicular histology of animals treated with high doses of dimethoate generally showed span of Sertoli cells destruction and disorganization of the germinal epithelium. The lumen of seminiferous tubules of treated rats was generally poor in sperm. The results of this study confirmed that dimethoate seriously deteriorate the male reproductive system resulting in decreased fertility.

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Section: Discussionsupporting

confidence: 82%

Effect of Dimethoate (An Organophosphate Insecticide) on the Reproductive System and Fertility of Adult Male Rat

Ngoula¹

2014

American Journal of Pharmacology and Toxicology

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“…The reduction in testicular weight may be due to reduced tubule size, spermatogenic arrest, and inhibition of steroid biosynthesis of Leydig cells [16]. Diminutions in the weight of accessory reproductive organs directly support the curtailed availability of androgen [17].…”

Section: Biological Evaluationmentioning

confidence: 99%

Synthesis, Characterization, and Evaluation of Antimicrobial and Antifertility Efficacy of Heterobimetallic Complexes of Copper (II)

Chaudhary

Singh

2017

Journal of Chemistry

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Heterobimetallic complexes of the copper with remarkable antimicrobial and antifertility action have been synthesized by the conventional method by reacting CuCl 2 and o-phenylenediamine in the methanolic medium forming the mononuclear complex of the type [Cu(C 6 H 8 N 2 ) 2 ]Cl 2 which was further treated with group 4 or 14 organometallic dichlorides (Ph 2 M Cl 2 , Me 2 M Cl 2 , and Cp 2 M Cl 2 ) [M = Sn, Si, and M = Ti, Zr] leading to formation of heterobimetallic complexes. All the synthesized complexes were characterized in the light of various physicochemical techniques like elemental analyses, conductivity measurements, molecular weight determination, electronic and infrared spectra, electronic spin resonance, X-ray, and mass spectral studies. The in vitro antibacterial activity of synthesized complexes against Escherichia coli and Staphylococcus aureus was tested to evaluate their inhibiting activities. The antifungal activities of mono-and heterobimetallic complexes were studied by screening the compounds against Fusarium oxysporum and Alternaria alternata. These complexes were then investigated to reveal their effect on the reproductive organs of male rats. The treatment has shown substantial decline in the sperm motility and density signifying the imperious antifertility activity.

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“…Each of the male and female groups included 30 rats and were divided into 5 groups: control (without any intervention), sham group (received only pure olive oil daily), treatment group 1 (received DZN+ olive oil daily, 60 mg/kg), treatment group 2 (received DZN, 60 mg/kg + vitamin E, 200 mg/kg daily) and treatment group 3 (received vitamin E daily, 200 mg/ kg). In this study, olive oil was used as solvent (14,(35)(36)(37)(38)(39). DZN and solvent were administrated by intraperitoneal injection and vitamin E was given by gavage.…”

Section: Animalsmentioning

confidence: 99%

Gender-Related Differences in Sensitivity to Diazinon in Gonads of Adult Rats and the Protective Effect of Vitamin E

Sargazi¹,

Nikravesh²,

Jalali³

et al. 2015

IJWHR

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Influence of methyl parathion on reproductive parameters in male rats

Cited by 78 publications

References 16 publications

Effect of Dimethoate (An Organophosphate Insecticide) on the Reproductive System and Fertility of Adult Male Rat

Effect of Dimethoate (An Organophosphate Insecticide) on the Reproductive System and Fertility of Adult Male Rat

Synthesis, Characterization, and Evaluation of Antimicrobial and Antifertility Efficacy of Heterobimetallic Complexes of Copper (II)

Gender-Related Differences in Sensitivity to Diazinon in Gonads of Adult Rats and the Protective Effect of Vitamin E

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