Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies

Chávez-Hidalgo, Lourdes Pilar; Martín-Fernández-de-Labastida, Silvia; Pancorbo, Marian M. de; Izaga, Marta Arroyo

doi:10.3748/wjg.v29.i7.1219

Cited by 3 publications

(3 citation statements)

References 37 publications

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“…Global modulation of the epigenome has been associated with the presence-absence of some substances. For example, insufficient availability of zinc resulted in decreased SAM-dependent methylation of rat liver leading to global DNA hypomethylation [28]. Similar results were also obtained with selenium deficiency both on Caco2 cells and in mice experiments [29].…”

Section: Substances Affecting the Epigenomesupporting

confidence: 70%

“…Curiously, both deficient and excessive amount of arsenic are associated with DNA hypomethylation suggesting a complex relationship of this substance with epigenome regulation [30]. On the contrary, increased amount of retinoic acid, a vitamin A active metabolite, led to genome hypomethylation and is associated with greater incidence of tumor [28]. Since methylation occurrence is linked to SAM availability, which is the only methyl donor in DNA, histone and RNA methylation processes, its concentration is obviously crucial for any methylation process.…”

Section: Substances Affecting the Epigenomementioning

confidence: 99%

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The Nutriepigenome

Mirisola

2023

Genes

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Unlike genetic changes, epigenetics modulates gene expression without stable modification of the genome. Even though all cells, including sperm and egg, have an epigenome pattern, most of these modifications occur during lifetime and interestingly, some of them, are reversible. Lifestyle and especially nutrients as well as diet regimens are presently gaining importance due to their ability to affect the epigenome. On the other hand, since the epigenome profoundly affects gene expression profile it can be speculated that the epigenome could modulate individual response to nutrients. Recent years have thus seen growing interest on nutrients, macronutrients ratio and diet regimens capable to affect the epigenetic pattern. In fact, while genetic alterations are mostly detrimental at the individual level, reshaping the epigenome may be a feasible strategy to positively counteract the detrimental effect of aging. Here, I review nutrient consumption and diet regimens as a possible strategy to counteract aging-driven epigenome derangement.

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Section: Substances Affecting the Epigenomesupporting

confidence: 70%

Section: Substances Affecting the Epigenomementioning

confidence: 99%

The Nutriepigenome

Mirisola

2023

Genes

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“…WJG v29i7: Overall, the articles are interesting but I especially like: (1) Colorectal cancer topic: “Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies”[ 19 ]. However, there is a clear disconnect between reviewer 00068967’s rating of scientific quality as excellent and his/her specific comments; (2) Chronic pancreatitis topic: “Advances in acute and chronic pancreatitis”[ 20 ]; and (3) Inflammatory bowel disease topic: “Mucosal healing and inflammatory bowel disease: Therapeutic implications and new targets”[ 21 ].…”

Section: Hot Articles and Insufficient Articlesmentioning

confidence: 99%

Editor-in-Chief articles of choice and comments at the year-end of 2023

Tarnawski

2024

World J Gastroenterol

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As the Editor-in-Chief, every week prior to a new issue’s online publication, I perform a careful review of all encompassed articles, including the title, clinical and/or research importance, originality, novelty, and ratings by the peer reviewers. Based on this review, I select the papers of choice and suggest pertinent changes (e.g. , in the title) to the Company Editors responsible for publication. This process, while time-consuming, is very important for assuring the quality of publications and highlighting important articles that Readers may revisit.

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Recommendations for articles and reviews in colorectal cancer-related research at the year-end of 2023

Luan,

Lin,

Miao

2024

World J Gastroenterol

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As peer reviewers of the World Journal of Gastroenterology , our weekly routine involves immersing ourselves in the newly published issue, particularly focusing on the realm of colorectal cancer (CRC) research. We diligently sift through various contributions, ranging from comprehensive reviews to original articles and other scholarly works. Through meticulous examination, we discern the most notable papers, delving into each with careful scrutiny to distill their merits and shortcomings. Undoubtedly, this undertaking demands considerable time and effort. Yet, it stands as an indispensable pursuit, affording us a profound comprehension of the latest breakthroughs in CRC research. Moreover, these meticulously curated selections furnish readers with invaluable resources, serving as enduring references for the nuanced exploration of this dynamic field.

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Influence of methyl donor nutrients as epigenetic regulators in colorectal cancer: A systematic review of observational studies

Cited by 3 publications

References 37 publications

The Nutriepigenome

The Nutriepigenome

Editor-in-Chief articles of choice and comments at the year-end of 2023

Recommendations for articles and reviews in colorectal cancer-related research at the year-end of 2023

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