Published estimates of methane emissions from atmospheric data (top-down approaches) exceed those from source-based inventories (bottom-up approaches), leading to conflicting claims about the climate implications of fuel switching from coal or petroleum to natural gas. Based on data from a coordinated campaign in the Barnett Shale oil and gas-producing region of Texas, we find that top-down and bottom-up estimates of both total and fossil methane emissions agree within statistical confidence intervals (relative differences are 10% for fossil methane and 0.1% for total methane). We reduced uncertainty in top-down estimates by using repeated mass balance measurements, as well as ethane as a fingerprint for source attribution. Similarly, our bottom-up estimate incorporates a more complete count of facilities than past inventories, which omitted a significant number of major sources, and more effectively accounts for the influence of large emission sources using a statistical estimator that integrates observations from multiple ground-based measurement datasets. Two percent of oil and gas facilities in the Barnett accounts for half of methane emissions at any given time, and high-emitting facilities appear to be spatiotemporally variable. Measured oil and gas methane emissions are 90% larger than estimates based on the US Environmental Protection Agency's Greenhouse Gas Inventory and correspond to 1.5% of natural gas production. This rate of methane loss increases the 20-y climate impacts of natural gas consumed in the region by roughly 50%. methane emissions | oil and gas emissions | greenhouse gas footprint | natural gas supply chain | Barnett Shale M ethane (CH 4 ), the principal component of natural gas, is a powerful greenhouse gas. Although natural gas emits less carbon dioxide (CO 2 ) per unit of energy than coal or oil when burned, CH 4 losses during the production, processing, transportation, and use of natural gas reduce its climate advantage compared with other fossil fuels. For example, if CH 4 losses are large enough (e.g., ∼3% of production), new natural gas power plants can cause greater climate damage than new coal plants for decades or longer (∼1% when comparing natural gas to diesel freight trucks) (1).The lack of current data on CH 4 emissions, magnified by intense public concern over the broader environmental implications of shale gas development, has stimulated significant research to improve estimates of CH 4 emissions (2-18). A recurring theme in recent literature is that "top-down" (TD) approaches produce estimates that are significantly higher than those from "bottomup" (BU) approaches. Concerns about available inventories and divergent TD and BU estimates create confusion regarding policy formulation and leave room for conflicting claims about the greenhouse gas implications of increased use of natural gas.TD approaches for estimating total CH 4 emissions at the regional or larger scale include airborne mass balance (2-4, 19), atmospheric transport models (5,6,(20)(21)(22)(23), and enhancem...