Influence of Metformin and Its Combination With Sodium Hydrogen Sulphide on H2 S System and Associated Biochemical Disorders in Myocardium and Kidney of Rats With Streptozotocininduced Diabetes

Pharmacology of Hydrogen Sulfide and Its Donors in Cardiometabolic Diseases

“…In diabetic mice, both circulating and myocardial H 2 S levels are inhibited, while H 2 S mitigates diabetes-induced cardiomyopathy in these mice (Barr et al, 2015). Similarly, STZ-induced rats displayed a conspicuous reduction in cardiac H 2 S concentration (Palamarchuk et al, 2020). These results underscored the crucial role of endogenous H 2 S in DCM progression.…”