Influence of Metabolic Syndrome on Vibration Perception Threshold in First-Degree Relatives of Type 2 Diabetes Mellitus

Yang, Lili; Peng, Yun; Liu, Dan; Zhang, Zhen; Yu, Xiaobing; Li, Fangping

doi:10.4236/ym.2021.51005

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…The vibration perception threshold (VPT) is of great medical importance. It is a fundamental tool for evaluating human somatosensory function and diagnosing peripheral neuropathy in clinical practice and research, especially in diabetic patients [6,7]. It can be used as a tool for research into occupational health to screen workers at workplace for peripheral neuropathy caused by direct vibration or toxic substances [7,8].…”

Section: Introductionmentioning

confidence: 99%

Assessing the vibration perception threshold in a community sample of adult Ghanaians

Djankpa,

Amoah,

Adzaku

et al. 2023

PLoS ONE

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Background The vibration perception threshold (VPT) helps evaluate human somatosensory function and diagnose peripheral neuropathy. To optimize its use as a primary neurologic tool, it is imperative to establish its typical values in healthy subjects and assess the factors affecting its variability in an individual to ensure consistency in its application. Methods Demographic data and a brief medical history were collected from 391 non-diabetic adults aged 30–80 at Kpone-on-Sea in Ghana. The VPT was measured at the tip of the big toe, the medial malleolus, the tip of the middle finger, and the head of the ulna of each participant using a Horwell Neurothesiometer. The variability of VPT was assessed vis-à-vis the following factors: gender, age, fasting plasma sugar and body mass index. Results The mean age of participants was 48.4 ± 0.7 years, and the female-to-male ratio was 1.46. The overall VPT values ranged from 5.74 ± 0.14 volts to 8.55 ± 0.18 volts in the lower limbs and 3.61 ± 0.06 volts to 5.00 ± 0.08 volts in the upper limbs. Age was found to be the only factor that could predict VPT for both the lower and upper limbs (P < 0.001). One-Way Analysis of Variance with Tukey’s posthoc showed that the VPT in the feet was significantly higher than that in the hands. Conclusions Generally, the VPT was high on proximal sites and low on distal sites indicating that the vibration sensation increased from proximal to distal direction. Therefore, distal areas should be used for VPT testing with a Neurothesiomer. Age was found to be the only factor that affected VPT variability. Hence, the practical application of VPT will require age-specific reference ranges to cater for older adults.

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Section: Introductionmentioning

confidence: 99%

Assessing the vibration perception threshold in a community sample of adult Ghanaians

Djankpa,

Amoah,

Adzaku

et al. 2023

PLoS ONE

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“…Compensatory high levels of Insulin in the blood aids in the maintenance of normal glucose in the blood-often for years-before the onset of diabetes [11]. Conclusively, pancreatic beta cells cannot overpower insulin resistance by over secretion and manifest by increased glucose levels, leading to diabetes [12]. Patients with T2DM are hyperinsulinemic until the illness has progressed to an advanced state.…”

Section: Introductionmentioning

confidence: 99%

Insulin Resistance in Type II Diabetes Mellitus Patients and Their First Degree Relatives- An Observational Study

Sati

Varma²,

Kumar

et al. 2021

JPRI

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Type II diabetes (T2DM) is caused by environmental, genetic, metabolic, and unknown variables. In diabetics, insulin resistance is the most of prolonged hyperglycemia. T2DM is induced by insulin resistance and cell dysfunction. The interaction of genetics and environment further complicates T2DM development. Insulin resistance and beta cell dysfunction are two of the most common Type 2 Diabetes Mellitus symptoms. A vicious triangle of cell failure (80% cell function) and insulin resistance in the muscles and liver causes major physiological issues. A group of diabetes patients (Group I), non-diabetic first-degree relatives of diabetic patients (Group II), and a non-diabetic healthy control group (Group III) were studied. The diabetes patients had the greatest systolic and diastolic blood pressures, followed by first degree relatives and healthy controls. We found that people with diabetes had higher fasting (FBS) and postprandial sugar, glycated haemoglobin (HbA1c) than diabetic offsprings and control group. Moreover, fasting insulin levels are higher in first degree relatives than in diabetes patients in the control group. The HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) levels of diabetics and their progeny do not differ much. The HOMA-IR measures insulin resistance severity. Common reference levels for HOMA-IR insulin resistance range from 0.7 - 2. Insulin resistance in diabetics and their first-degree relatives is evident from the results.

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Influence of Metabolic Syndrome on Vibration Perception Threshold in First-Degree Relatives of Type 2 Diabetes Mellitus

Cited by 2 publications

References 19 publications

Assessing the vibration perception threshold in a community sample of adult Ghanaians

Assessing the vibration perception threshold in a community sample of adult Ghanaians

Insulin Resistance in Type II Diabetes Mellitus Patients and Their First Degree Relatives- An Observational Study

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