Influence of Metabolic Syndrome and General Obesity on the Risk of Ischemic Stroke

Chen, Hsin-Jen; Bai, Chyi Huey; Yeh, Wen Ting; Chiu, Hou Chang; Pan, Wen Harn

doi:10.1161/01.str.0000206458.58142.f3

Cited by 128 publications

(101 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A previous validation study comparing ICD coding and hospital record review in Taiwan has showed that sensitivity and specificity for major cardiovascular events such as stroke were 100% and 95%, respectively, suggesting the high positive predictive value for a major cardiovascular event in which hospitalization is needed. (39) Another study also demonstrated a high positive predictive value up to 95% for acute myocardial infarction diagnosis after comparing ICD coding from Medicare claims and a diagnosis based on structured hospital record review, (40) further supporting the accuracy of AMI diagnosis in our study. Third, although hip fracture patients had higher mortality in the current study, we did not know the exact cause of death for each enrollment, especially those deaths that occurred outside of hospitals.…”

Section: Discussionsupporting

confidence: 80%

Hip fracture and risk of acute myocardial infarction: A nationwide study

Chiang

Liu

Chen

et al. 2012

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

Osteoporotic fractures are associated with increased mortality risk. However, little data are available on the risk of acute myocardial infarction (AMI) after hip fracture. Therefore, we investigated whether hip fracture increased the risk of AMI in a large, nationwide cohort study. We obtained data from 8758 patients diagnosed with hip fracture from 2000 to 2009 and from 4 matched controls for each patient from the Longitudinal Health Insurance Database (LHID 2000), Taiwan. Controls were matched for age, sex, comorbid disorders, and enrollment date. All subjects were followed up from the date of enrollment until AMI, death, or the end of data collection (2009). Cox's regression model adjusted for age, sex, comorbid disorders, and medication was used to assess independent factors determining the risk of development of AMI. As expected, despite the matching, the hip fracture patients had more risk factors for AMI at baseline. A total of 8758 subjects with hip fractures and 35,032 controls were identified. Among these patients, 1183 (257 hip fracture patients and 926 controls) developed AMI during the median 3.2-year (interquartile range 1.4 to 5.8 years) follow-up period. Patients with hip fractures had a higher incidence of AMI occurrence when compared with controls (8.7/1000 person-years versus 6.82/1000 person-years). Multivariate analysis adjusted for baseline covariates indicated that hip fracture was associated with a greater risk for AMI development (hazard ratio [HR] ¼ 1.29; 95% confidence interval [CI] 1.12-1.48; p < 0.001). We conclude that hip fracture is independently associated with a higher risk of subsequent AMI. ß

show abstract

Section: Discussionsupporting

confidence: 80%

Hip fracture and risk of acute myocardial infarction: A nationwide study

Chiang

Liu

Chen

et al. 2012

Journal of Bone and Mineral Research

View full text Add to dashboard Cite

show abstract

“…Obesity and overweight have been widely studied because they entail serious medical problems such as non-alcoholic fatty liver disease, cardiovascular disease, stroke, and endothelial dysfunction (Lteif et al 2005, Chen et al 2006, Bell 2009, Khoshdel et al 2012. Maternal obesity and overweight affect fetal growth and development.…”

Section: Introductionmentioning

confidence: 99%

Saturated fat-rich diet increases fetal lipids and modulates LPL and leptin receptor expression in rat placentas

Mazzucco

Higa

Capobianco

et al. 2013

Journal of Endocrinology

View full text Add to dashboard Cite

Metabolic alterations in obese and overweight mothers impact the placenta and the fetus, leading to anomalies in fetal growth and lipid accretion. The primary aim of the study was to examine the effect of a saturated fat-rich diet (FD) on growth, lipid accretion, and lipases, leptin and leptin receptor (ObR) expression in the placenta and fetal liver. We also aimed to find a role for fetal leptin in the modulation of placental and fetal liver lipase and ObR expression. Six-week-old rats were fed with a standard rat chow (control) or a 25% FD for 7 weeks until mating and during pregnancy. Also, in a group of control rats, fetuses were injected with leptin on days 19, 20, and 21 of pregnancy. On day 21, we assessed lipidemia, insulinemia, and leptinemia in mothers and fetuses. In the placenta and fetal liver, lipid concentration was assessed by thin layer chromatography (TLC) and the gene expression of lipoprotein lipase (LPL), endothelial lipase, insulin receptor (Insr), leptin, and ObR by RT-PCR. The FD induced hypertriglyceridemia and hyperleptinemia (P!0.01) in mothers and fetuses, an increase in maternal (P!0.05) and fetal weight (P!0.01), overaccumulation of lipids in fetal liver (P!0.01), and enhanced leptin expression in the placenta and fetal liver (P!0.05). Placental expression of IR and LPL was increased (P!0.05), and ObR decreased (P!0.05) in the FD group. Fetal administration of leptin induced the placental and fetal liver downregulation of ObR (P!0.05) and upregulation of LPL expression (P!0.05). The FD led to increased fetal lipid levels, which may result from high maternal lipid availability and fetal leptin effects. Key Words" Saturated fat-rich diet

show abstract

“…Although metabolic syndrome has been recognized as a risk factor for atherosclerotic diseases such as coronary heart disease (2,3) and ischemic stroke (4)(5)(6)(7)(8), genetic risk for ischemic stroke in individuals with metabolic syndrome has remained uncharacterized. Given that stroke is the leading cause of severe disability and the third leading cause of death, after heart disease and cancer, in western countries and Japan (9), the identification of biomarkers for stroke risk is important both for risk prediction and for intervention to avert future events.…”

Section: Introductionmentioning

confidence: 99%

Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome

Yamada

Kato²,

Oguri³

et al. 2008

Int J Mol Med

View full text Add to dashboard Cite

Abstract. Metabolic syndrome is a risk factor for cardiovascular disease. The aim of the present study was to identify genetic variants that confer susceptibility to atherothrombotic cerebral infarction among individuals with metabolic syndrome in order to allow prediction of genetic risk for this condition. The study population comprised 1284 unrelated Japanese individuals with metabolic syndrome, including 313 subjects with atherothrombotic cerebral infarction and 971 controls. The genotypes for 296 polymorphisms of 202 candidate genes were determined with a method that combines the polymerase chain reaction and sequence-specific oligonucleotide probes with suspension array technology. The Chisquare test, multivariable logistic regression analysis with adjustment for age, sex, body mass index, and the prevalence of hypertension, hypercholesterolemia, and diabetes mellitus, as well as a stepwise forward selection procedure revealed that the 2445G¨A (Ala54Thr) polymorphism (rs1799883) of FABP2, the -108/3G¨4G polymorphism of IPF1 (S82168), the A¨G (Thr94Ala) polymorphism (rs2241883) of FABP1, the G¨A (Asp2213Asn) polymorphism (rs529038) of ROS1, the -11377C¨G polymorphism (rs266729) of ADIPOQ, the 162A¨C polymorphism (rs4769055) of ALOX5AP, the -786T¨C polymorphism (rs2070744) of NOS3, and the 3279C¨T polymorphism (rs7291467) of LGALS2 were associated (P<0.05) with the prevalence of atherothrombotic cerebral infarction. Among these polymorphisms, the 2445G¨A (Ala54Thr) polymorphism of FABP2 was most significantly associated with this condition. Our results suggest that FABP2, IPF1, FABP1, ROS1, ADIPOQ, ALOX5AP, NOS3, and LGALS2 are susceptibility loci for atherothrombotic cerebral infarction among Japanese individuals with metabolic syndrome. Genotypes for these polymorphisms, especially for the 2445G¨A (Ala54Thr) polymorphism of FABP2, may prove informative for the prediction of genetic risk for atherothrombotic cerebral infarction among such individuals.

show abstract

Influence of Metabolic Syndrome and General Obesity on the Risk of Ischemic Stroke

Cited by 128 publications

References 18 publications

Hip fracture and risk of acute myocardial infarction: A nationwide study

Hip fracture and risk of acute myocardial infarction: A nationwide study

Saturated fat-rich diet increases fetal lipids and modulates LPL and leptin receptor expression in rat placentas

Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome

Contact Info

Product

Resources

About