Influence of metabolic status on oocyte quality and follicular characteristics at different postpartum periods in primiparous rabbit does

Arias-Álvarez, M.; García-García, R.M.; Rebollar, Paloma García; Revuelta, Luis; Millán, P.; Lorenzo, P.L.

doi:10.1016/j.theriogenology.2009.04.017

Cited by 33 publications

(31 citation statements)

References 60 publications

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“…In agreement with the present study, rat models of obesity have impaired ovarian follicular growth with increased apoptosis [21], [55], but no difference in morphology nor in the number of antral follicles [21]. In the rabbit, the ovarian cortex is thin and is characterized by a small number of primordial and small developing follicles with a higher number of mature follicles [56], [57]. In terms of reproduction, rabbit females are characterized by the fact that mating induces ovulation.…”

Section: Discussionsupporting

confidence: 90%

Dietary Lipid and Cholesterol Induce Ovarian Dysfunction and Abnormal LH Response to Stimulation in Rabbits

et al. 2013

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Background/AimExcess of fat intake is dramatically increasing in women of childbearing age and results in numerous health complications, including reproductive disorders. Using rabbit does as a biomedical model, the aim of this study was to evaluate onset of puberty, endocrine responses to stimulation and ovarian follicular maturation in females fed a high fat high cholesterol diet (HH diet) from 10 weeks of age (i.e., 2 weeks before normal onset of puberty) or a control diet (C diet).Methodology/Principal FindingsThree experiments were performed, each including 8 treated (HH group) and 8 control (C group) does. In experiment 1, the endocrine response to Gonadotropin releasing hormone (GnRH) was evaluated at 13, 18 and 22 weeks of age. In experiment 2, the follicular population was counted in ovaries of adult females (18 weeks of age). In experiment 3, the LH response to mating and steroid profiles throughout gestation were evaluated at 18 weeks of age. Fetal growth was monitored by ultrasound and offspring birth weight was recorded. Data showed a significantly higher Luteinizing hormone (LH) response after induction of ovulation at 13 weeks of age in the HH group. There was no difference at 18 weeks, but at 22 weeks, the LH response to GnRH was significantly reduced in the HH group. The number of atretic follicles was significantly increased and the number of antral follicles significantly reduced in HH does vs. controls. During gestation, the HH diet induced intra-uterine growth retardation (IUGR).ConclusionThe HH diet administered from before puberty onwards affected onset of puberty, follicular growth, hormonal responses to breeding and GnRH stimulation in relation to age and lead to fetal IUGR.

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Section: Discussionsupporting

confidence: 90%

Dietary Lipid and Cholesterol Induce Ovarian Dysfunction and Abnormal LH Response to Stimulation in Rabbits

et al. 2013

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“…The most common management system in commercial rabbit farming in Europe is semi-intensive, with a minimum interval between kindling and artificial insemination or natural mating of between 10 and 12 days (Arias-Alvarez et al, 2009), resulting in overlap between lactation and gestation. Modern commercial rabbit breeds have large litter sizes of around 10 kits (Khalil and Baselga, 2002).…”

Section: Introductionmentioning

confidence: 99%

Relationship between cortisol and acute phase protein concentrations in female rabbits

Argente

Garcia

Birlanga

et al. 2014

The Veterinary Journal

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“…High yielding animal producers like high-producing dairy cows or primiparous rabbits are often in a serious negative energy balance (NEB) in some physiological phases, that is, lactation, since the net nutrient requirements are more elevated than the net nutrient intake in that stages (cows: [12, 13]; rabbits: [14]). NEB provokes low reproductive performance.…”

Section: Introductionmentioning

confidence: 99%

“…In any case, changes in the growth pattern of the ovarian follicle during a period of NEB can indirectly affect oocyte quality that is ultimately responsible for the subfertility in dairy cows [22]. In other species with high requirements in early postpartum period like primiparous rabbit does, they show a profound NEB which negatively impacts on ovarian follicular and oocyte quality, giving rise to a poor reproductive performance too [14, 23]. …”

Section: Introductionmentioning

confidence: 99%

Integrative Control of Energy Balance and Reproduction in Females

García-García

2012

ISRN Veterinary Science

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There is a strong association between nutrition and reproduction. Chronic dietary energy deficits as well as energy surpluses can impair reproductive capacity. Metabolic status impacts reproductive function at systemic level, modulating the hypothalamic GnRH neuronal network and/or the pituitary gonadotropin secretion through several hormones and neuropeptides, and at the ovarian level, acting through the regulation of follicle growth and steroidogenesis by means of the growth hormone-IGF-insulin system and local ovarian mediators. In the past years, several hormones and neuropeptides have been emerging as important mediators between energy balance and reproduction. The present review goes over the main sites implicated in the control of energy balance linked to reproductive success and summarizes the most important metabolic and neuroendocrine signals that participate in reproductive events with special emphasis on the role of recently discovered neuroendocrine peptides. Also, a little overview about the effects of maternal nutrition, affecting offspring reproduction, has been presented.

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Influence of metabolic status on oocyte quality and follicular characteristics at different postpartum periods in primiparous rabbit does

Cited by 33 publications

References 60 publications

Dietary Lipid and Cholesterol Induce Ovarian Dysfunction and Abnormal LH Response to Stimulation in Rabbits

Dietary Lipid and Cholesterol Induce Ovarian Dysfunction and Abnormal LH Response to Stimulation in Rabbits

Relationship between cortisol and acute phase protein concentrations in female rabbits

Integrative Control of Energy Balance and Reproduction in Females

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