Influence of menstrual cycle on NK activity

Souza, Saulo Soares de; Castro, Fabíola Attié de; Mendonca, Heliodora Carneiro de; Palma, Patrícia Vianna Bonini; Morais, F. R.; Ferriani, Rui Alberto; Voltarelli, Júlio César

doi:10.1016/s0165-0378(00)00091-7

Cited by 76 publications

(50 citation statements)

References 18 publications

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“…Studies are inconsistent in regard to NK activity during a menstrual cycle. Souza et al (30) reported increased NK activity in follicular phase as compared with luteal phase. Contrary to this, Sulke et al (31) reported a significantly decreased NK cytotoxicity during periovulatory period as compared with normal male volunteers.…”

Section: Discussionmentioning

confidence: 97%

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Fluctuation of Peripheral Blood T, B, and NK Cells during a Menstrual Cycle of Normal Healthy Women

Lee¹,

Kim²,

Jang³

et al. 2010

The Journal of Immunology

105

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Cyclical hormonal changes during an ovarian cycle may affect immune responses, which is crucial for the embryonic implantation. We aim to investigate whether the levels and activity of T, B, and NK cells change during a menstrual cycle. Twenty-two normally cycling women were enrolled and peripheral blood was drawn serially during a menstrual cycle. Intracellular cytokine expression of CD3+CD4+ and CD3+CD8+ cells, and Th1/Th2 cytokine-producing T cell ratios were determined using flow cytometric analysis. NK cell cytotoxicity was measured by flow cytometric analysis at E:T ratios of 50:1, 25:1, and 12.5:1 and also using LU at 20%. Proportions (percentage) of CD3+ (p = 0.046) and CD3+CD4+ (p = 0.002) T cells were increased in the follicular phase compared with the luteal phase. The levels of CD3−CD56+ (p = 0.010) and CD3−CD56dim (p = 0.012) NK cells and NK cytotoxicity at E:T ratio of 50:1, 25:1, and 12.5:1 and LU at 20% were significantly increased in the luteal phase compared with the follicular phase. Even though IL-10–producing CD3+CD4+ T cells were significantly lower in the midluteal phase as compared with the early follicular phase, proportions of CD19+ B cells, CD3+CD56+ NKT cells, Th1 cytokine-producing T cell subsets, and ratios of Th1/Th2 cytokine-producing T cells were not significantly changed during a menstrual cycle. We conclude that peripheral blood NK and T cell levels as well as NK cytotoxicity are changed during a menstrual cycle. Neuroendocrine regulation on immune responses is suggested during an ovarian cycle, which may be critical for embryonic implantation and pregnancy.

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Section: Discussionmentioning

confidence: 97%

“…NK cytotoxicity has been known to be upregulated by IFN-g, adrenocorticotropic hormone, b-endorphin, and prolactin and downregulated by glucocorticoids, lymphocyte immunotherapy, and i.v. IgG (30,34). Progesterone was also reported not to influence on NK activity (30).…”

Section: Discussionmentioning

confidence: 97%

Fluctuation of Peripheral Blood T, B, and NK Cells during a Menstrual Cycle of Normal Healthy Women

Lee¹,

Kim²,

Jang³

et al. 2010

The Journal of Immunology

105

View full text Add to dashboard Cite

show abstract

“…Since it has been reported that menstruation significantly affects NK activity (Souza et al, 2001),the influence of menstruation on NK activity was controlled during our experiments in female subjects.…”

Section: Effect Of Forest Environments On Nk Activity In Female Subjectsmentioning

confidence: 99%

Nature Therapy and Preventive Medicine

Lee¹,

Li²,

Tyrväinen³

et al. 2012

Public Health - Social and Behavioral Health

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“…Sorachi K, et al (9) found that estrogen could enhance the in vitro cytotoxicity in YT-N17 (a human NK-like cell line). Seaman et al (10) reported that estrogen decreased the NK activity in vivo. These inconsistent results may attribute to the difference in the sources and purity of NK cells.…”

Section: Introductionmentioning

confidence: 99%

17β-Estradiol Suppresses Cytotoxicity and Proliferative Capacity of Murine Splenic NK1.1+ Cells

Hao

Zhao

et al. 2008

Cell Mol Immunol

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In order to clarify the effects of 17β-estradiol (E2) on natural killer (NK) cells and the possibly regulatory mechanisms, we obtained highly purified and viable NK cells from C57BL/6J mouse spleen by a magnetic cell sorter (MACS). These cells were treated with E2 and then their cytotoxicity and proliferative capacity were examined. To further investigate the mechanisms on the effect of E2 on NK cells, expressions of activationassociated markers (CD69, CD122) and inhibitory receptors (CD94, Ly49), and intracellular cytokine production were analyzed. At last, we performed the cDNA microarray to explore the possible involved genes. We found that E2 could suppress NK cell cytotoxicity and proliferative capacity in vitro. E2 reduced NK cell cytotoxicity and proliferative capacity, which may be through influencing the phenotypes and cytokine expression of NK cells, mainly involving CD94 and IFN-γ. Furthermore, regulation of Stat4, Fyn, Sh2d1a, Eat2, Cd244, Irf1, Runx1, Irf7, Irf5, Esrra and Nr5a1 genes may be related to the cytotoxicity, proliferation and cytokine production of E2-mediated purified NK cells. Cellular & Molecular Immunology. 2008;5(5):357-364.

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Influence of menstrual cycle on NK activity

Cited by 76 publications

References 18 publications

Fluctuation of Peripheral Blood T, B, and NK Cells during a Menstrual Cycle of Normal Healthy Women

Fluctuation of Peripheral Blood T, B, and NK Cells during a Menstrual Cycle of Normal Healthy Women

Nature Therapy and Preventive Medicine

17β-Estradiol Suppresses Cytotoxicity and Proliferative Capacity of Murine Splenic NK1.1+ Cells

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