Influence of membrane character on suppression of coffee-ring effect

Shahruddin, Sarah Sorfeena; Ideris, Norhidayah; Bakar, Noor Fitrah Abu; Ahmad, Abdul Latif; Lah, Nuur Fahanis Che

doi:10.1016/j.matpr.2021.01.761

Cited by 6 publications

(5 citation statements)

References 17 publications

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“…The pore size distribution of the pristine PES and PES[6 +][0] was determined using an open-source image analysis tool (ImageJ, https://imagej.nih.gov ). The details of the image analysis procedure are similar to that of Shahruddin et al [ 29 ]. The pore size distribution represents the population analysis of various pore diameters present on the membranes’ surface.…”

Section: Resultsmentioning

confidence: 99%

Hydrophilized Ultrafiltration Membranes Synthesized from Acrylic Acid Grafted Polyethersulfone for Downstream Processing of Therapeutic Insulin and Cobalamin

Prasad

Gayatri

Sandhya

et al. 2022

Appl Biochem Biotechnol

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The present study focuses on synthesis of novel high-performance acrylic acid (AA) grafted polyethersulfone (PES) ultrafiltration (UF) membranes for purification of small therapeutic biomolecules such as urea, insulin, and cobalamin. The membranes were indigenously synthesized by adding polyethylene glycol (PEG) of 6 kDa M.Wt. as a pore former and subsequent grafting of AA using 2 to 6 wt.% concentrations under UV-induced photo grafting. Scanning electron microscopy reveals that the PEG additive profoundly influences the pore density on the membrane surface. FTIR spectra confirm the graft polymerization of AA with the PES substrate. Separation performance of the grafted membranes was evaluated to establish the trade-off between the degree of grafting and MWCO. From the experimental results, the pure water flux (PWF) of 6% grafted PES membrane was enhanced from 8.5 (PES [0] [6]) to 18.20 l m−2 h−1 (PES [6 +] [6]) in the presence of PEG pore former, respectively. The grafting concentration window of 2–6% resulted in selective membranes to altogether remove uremic toxins into the permeate with retention of high molecular size proteins. Hence, 5 and 6 wt.% AA grafted membranes exhibited > 90% rejection for insulin and cobalamin biomolecules along with 24.5 and 23.8 l m−2 h−1 bar−1 permeability towards urea, respectively. The process results correlate well with the MWCO values of membranes ranging from 1 to 10 kDa. This work provides the efficacy of these grafted membranes for potential application in the downstream processing of therapeutic biomolecules such as insulin and cobalamin.

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Section: Resultsmentioning

confidence: 99%

Hydrophilized Ultrafiltration Membranes Synthesized from Acrylic Acid Grafted Polyethersulfone for Downstream Processing of Therapeutic Insulin and Cobalamin

Prasad

Gayatri

Sandhya

et al. 2022

Appl Biochem Biotechnol

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“…Moreover, the BMOF‐printed filter paper showed a 2‐fold higher cell capture capacity than BMOF‐printed PVDF (Figure 2c), which could be attributed to the “coffee ring” effect caused by the PVDF membrane. [ 36 ] Compared to the previous research, directly grafting PBA or other small molecules on the substrates usually requires extra steps of covalent modification, [ 10a,11,35 ] otherwise, these small molecules can be easily passed out through the substrate (i.e., filter paper) or buried underneath the substrate, thus leading to low PBA density on the surface. In our research, inkjet‐printing the BMOF nanoparticles on paper‐based substrate endows the IVDs with large surface roughness (as shown in the AFM image in Figure 1h and Figures S10 and S11: Supporting Information), which helps boronic functional groups to better present on the surface, thus increasing the interaction with cell targets.…”

Section: Resultsmentioning

confidence: 99%

De Novo Engineering of Metal–Organic Framework‐Printed In Vitro Diagnostic Devices for Specific Capture and Release of Tumor Cells

Liang

Liu

Lord

et al. 2021

Small

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monitoring of disease progression and treatment efficacy. [1] The efficient enrichment of biomarkers with high sensitivity and specificity is usually required for IVDs; however, the complex nature of body fluids (i.e., cell debris, normal blood cells, etc.) may hinder selective biomarker capture. [2] Moreover, the material capture mechanism may induce unrecoverable changes to biomarkers, affecting its accuracy. [2] Therefore, the choice of materials which enable efficient capture of native biomarkers with good cytocompatibility is critical.Various probes (e.g., aptamers, [3] peptides, [4] antibodies [5] ) have been applied to enhance the specificity of biomarker capture and detection. Additionally, nanomaterials have been integrated with biological probes due to their large surface area-to-volume ratio, such as nanofibers, [6] nanowires, [7] 2D materials, [8] and nanoparticles, [9] to improve the capacity to capture target cells. However, limitations of these biological sensing elements include the propensity to deactivate or degrade, high cost and experimentally time-consuming. [2] Non-biological functional groups with high-affinity to target cells are promising as they are more resistant to chemical or biological degradation and less expensive. [10] Boronic acid and its derivatives are such functional groups which can bind cell surface glycans (i.e., sialic acid) overexpressed on the surface of the tumor cells via reversible covalent bonds, enabling the selective capture and isolation of cancer cells. [10] Effective tumor cell capture can occur when boronic acid is constructed on substrates with nanoscale features [10] and only a few studies have reported the efficient capture of cancer cells by a single chemical group. [11] The development of highly efficient boronic acidrich materials have the potential to enhance the efficiency of specific tumor cell capture.Recently, metal-organic nanocomposite materials (e.g., metal-organic frameworks (MOFs), metal-organic cages (MOCs), metal-phenolic networks)) have attracted increasing attention. [12] In particular, MOFs constructed from organic linkers and metal ions or metal-containing clusters, possess versatile functionality, tailored pore size, and versatile composition and structure. [13] Consequently, MOFs have shown great potential in diverse applications including energy storage, [14] gas separation, [15] biopharmaceutical delivery [16] and heterogeneous Herein, a paper-based in vitro diagnostic device (IVD) is developed via inkjet printing of de novo engineered, boronic acid-rich metal-organic frameworks (BMOFs). The newly developed BMOFs simultaneously possess crystalline and amorphous structure, mesopore size, large surface area, and retain a high level of boronic acid integration. After printing the BMOFs on the filter paper, the BMOF-printed paper IVD shows a rapid response time (40 min) towards cancer cell capture and its maximum cell capture capacity reaches approximately (4.5 ±1.1) ×10 4 cells cm −2 . Furthermore, the BMOF-printed IVD shows nine times h...

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“…A sorbent surface commonly used for protein immobilization in immunodetection is a polymeric membrane (Surti et al, 2022). Nitrocellulose (Shahruddin et al, 2021), nylon (El-Moghazy et al, 2020), and poly (vinylidene fluoride) (PVDF) (Ahmad et al, 2016a) are the most common types of polymeric membrane for immobilization of the protein constituent, due to desirable characteristics such as stable and controllable surface properties, a large surface area, high binding affinity and stability of the biomolecules toward the substrate, simple handling and cheap large-scale production. Each of them has its strengths and weaknesses, in which the final selection of the membrane usually depends on the application of interest.…”

Section: Literature Reviewmentioning

confidence: 99%

Suppression of Coffee-ring Effect (CRE) in the Development of Low-cost Diagnostic Kit

Ideris,

Abu Bakar,

Ahmad

et al. 2024

E-BPJ

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One of the applications of membrane technology is using the polymeric membrane as an adsorber or assay-capturing matrix in the diagnostic kits' assembly. This study explores the addition of NaCl into a protein solution to suppress the coffee-ring effect (CRE) in developing a low-cost diagnostic kit. The highest concentration of NaCl addition shows the optimum results with no formation of CRE and high color intensity (low grey scale value). Adding NaCl into the protein solution is a safe and cheap alternative for lowering the cost of assembly, benefiting people in low-resource places.

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Influence of membrane character on suppression of coffee-ring effect

Cited by 6 publications

References 17 publications

Hydrophilized Ultrafiltration Membranes Synthesized from Acrylic Acid Grafted Polyethersulfone for Downstream Processing of Therapeutic Insulin and Cobalamin

Hydrophilized Ultrafiltration Membranes Synthesized from Acrylic Acid Grafted Polyethersulfone for Downstream Processing of Therapeutic Insulin and Cobalamin

De Novo Engineering of Metal–Organic Framework‐Printed In Vitro Diagnostic Devices for Specific Capture and Release of Tumor Cells

Suppression of Coffee-ring Effect (CRE) in the Development of Low-cost Diagnostic Kit

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