Influence of Medication on Nutritional Status

Boullata, Joseph I.

doi:10.1007/978-1-59259-880-9_34

Cited by 5 publications

(3 citation statements)

References 207 publications

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“…Drug-induced changes to overall nutritional status or to the status of a specific nutrient can be multifactorial. 55 Drugs can influence food intake, digestion, and absorption, and they can also affect nutrient distribution, metabolism, and excretion. A drug may alter food intake by effects not involving the gastrointestinal tract (e.g., cognitive disturbances, visual changes, gait abnormalities).…”

Section: Influence Of Drugs On Nutritional Statusmentioning

confidence: 99%

“…A drug may decrease a patient's ability to gather, prepare, or ingest food; it may also change nutrient absorption, distribution, metabolism, or excretion. 55 Some adverse effects of drugs may be directly related to an influence on the status of a nutrient; such effects cannot always be addressed by nutrient supplementation. For example, carbamazepine alters biotin status by decreasing its absorption and increasing its clearance.…”

Section: Influence Of Drugs On Nutritional Statusmentioning

confidence: 99%

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An Approach to Evaluating Drug-Nutrient Interactions

Santos

Boullata

2005

Pharmacotherapy

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Although the significance of interactions between drugs is widely appreciated, little attention has been given to interactions between drugs and nutrients. Pharmacists are challenged to remember documented interactions involving available drugs, and they face the possibility that each newly approved therapeutic agent may be involved not only in unrecognized drug-drug interactions but in drug-nutrient interactions as well. A more consistent approach to evaluating drug-nutrient interactions is needed. The approach must be systematic in order to assess the influence of nutritional status, food, or specific nutrients on a drug's pharmacokinetics and pharmacodynamics, as well as the influence of a drug on overall nutritional status or on the status of a specific nutrient. We provide such a process, using several recently approved drugs as working examples. Risk factors and clinical relevance are described, with distinctions made between documented and potential interactions. Application of this process by the pharmacist to any drug will help increase their expertise. Furthermore, full consideration by pharmacists of all possible interactions of the drug regimens used in practice can allow for improved patient care.

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Section: Influence Of Drugs On Nutritional Statusmentioning

confidence: 99%

Section: Influence Of Drugs On Nutritional Statusmentioning

confidence: 99%

An Approach to Evaluating Drug-Nutrient Interactions

Santos

Boullata

2005

Pharmacotherapy

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“…Medication can directly compete with micronutrients when they use the same metabolic and transport pathways, modifying the pharmacokinetics or micronutrient status [18][19][20] (absorption, distribution, metabolism, excretion) [21]. Physiochemical interactions are mostly represented by a chelation, causing loss of a nutrient and lower drug activity.…”

Section: Introduction 1drug-nutrient Interactions (Dnis)mentioning

confidence: 99%

Potential Drug–Nutrient Interactions of 45 Vitamins, Minerals, Trace Elements, and Associated Dietary Compounds with Acetylsalicylic Acid and Warfarin—A Review of the Literature

Renaud,

Höller,

Michel

2024

Nutrients

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In cardiology, acetylsalicylic acid (ASA) and warfarin are among the most commonly used prophylactic therapies against thromboembolic events. Drug–drug interactions are generally well-known. Less known are the drug–nutrient interactions (DNIs), impeding drug absorption and altering micronutritional status. ASA and warfarin might influence the micronutritional status of patients through different mechanisms such as binding or modification of binding properties of ligands, absorption, transport, cellular use or concentration, or excretion. Our article reviews the drug–nutrient interactions that alter micronutritional status. Some of these mechanisms could be investigated with the aim to potentiate the drug effects. DNIs are seen occasionally in ASA and warfarin and could be managed through simple strategies such as risk stratification of DNIs on an individual patient basis; micronutritional status assessment as part of the medical history; extensive use of the drug–interaction probability scale to reference little-known interactions, and application of a personal, predictive, and preventive medical model using omics.

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An Introduction to Drug–Nutrient Interactions

Boullata

2009

Handbook of Drug-Nutrient Interactions

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Influence of Medication on Nutritional Status

Cited by 5 publications

References 207 publications

An Approach to Evaluating Drug-Nutrient Interactions

An Approach to Evaluating Drug-Nutrient Interactions

Potential Drug–Nutrient Interactions of 45 Vitamins, Minerals, Trace Elements, and Associated Dietary Compounds with Acetylsalicylic Acid and Warfarin—A Review of the Literature

An Introduction to Drug–Nutrient Interactions

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