Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis

Patro-Gołąb, Bernadeta; Santos, Susana; Voerman, Ellis; Barros, Henrique; Bergström, Anna; Charles, Marie‐Aline; Chatzi, Leda; Chevrier, Cécile; Chrousos, George P.; Corpeleijn, Eva; Costet, Nathalie; Crozier, Sarah; Devereux, Graham; Eggesbø, Merete; Ekström, Sandra; Fantini, Maria Pia; Farchi, Sara; Forastiére, Francesco; Georgiu, Vagelis; Godfrey, Keith M.; Gori, Davide; Wojciech, Hanke; Hertz‐Picciotto, Irva; Heude, Barbara; Hryhorczuk, Daniel; Inskip, Hazel; Ibarluzea, Jesús; Kenny, Louise; Küpers, Leanne K.; Lagström, Hanna; Lehmann, Irina; Lenters, Virissa; Llop, Sabrina; Magnus, Per; Majewska, Renata; Mäkelä, Johanna; Μanios, Yannis; McAuliffe, Fionnuala M.; McDonald, Sheila; Mehegan, John; Mommers, Monique; Morgen, Camilla Schmidt; Moschonis, George; Murray, Deirdre M.; Chaoimh, Carol Ní; Nohr, Ellen A.; Andersen, Anne‐Marie Nybo; Oken, Emily; Oostvogels, Adriëtte J. J. M.; Pac, Agnieszka; Papadopoulou, Eleni; Pizzi, Costanza; Polańska, Kinga; Porta, Daniela; Richiardi, Lorenzo; Rifas‐Shiman, Sheryl L.; Rusconi, Franca; Santos, Ana Cristina; Smit, Henriëtte A.; Sørensen, Thorkild I A; Standl, Marie; Stoltenberg, Camilla; Sunyer, Jordi; Taylor, Michelle; Thiering, Elisabeth; Thijs, Carel; Torrent, Maties; Tough, Suzanne; Trnovec, T.; Turner, Steve; Rossem, Lenie van; Berg, Andrea von; Vrijheid, Martine; Vrijkotte, Tanja G. M.; West, Jane; Wright, John; Звінчук, Олександр; Lawlor, Debbie A.; Jaddoe, Vincent W. V.; Gaillard, Romy

doi:10.1016/s2352-4642(18)30273-6

Cited by 107 publications

(76 citation statements)

References 38 publications

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“…There is evidence that both maternal BMI and GDM are independently associated with adverse pregnancy outcomes, with maternal pre‐pregnancy BMI having a stronger influence than GDM on foetal macrosomia, Caesarean section, pre‐eclampsia, and large for gestational age . By comparison, the observed positive associations between maternal GDM and childhood overweight and obesity could be largely explained by maternal pre‐pregnancy BMI . Therefore, the observed increased risk of childhood‐onset T1DM with maternal GDM should also be interpreted within this context.…”

Section: Discussionsupporting

confidence: 92%

“…Thus, it is not surprising that both conditions share a number of common adverse maternal and offspring outcomes, which are also known to be risk factors for childhood‐onset T1DM. Similar to maternal overweight and obesity, maternal GDM is also associated with increased risks of high birthweight, preterm labour, pre‐eclampsia, Caesarean section, and childhood obesity (see Maternal overweight and obesity ). There is evidence that both maternal BMI and GDM are independently associated with adverse pregnancy outcomes, with maternal pre‐pregnancy BMI having a stronger influence than GDM on foetal macrosomia, Caesarean section, pre‐eclampsia, and large for gestational age .…”

Section: Discussionmentioning

confidence: 99%

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The influence of maternal body mass index, maternal diabetes mellitus, and maternal smoking during pregnancy on the risk of childhood‐onset type 1 diabetes mellitus in the offspring: Systematic review and meta‐analysis of observational studies

2019

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Summary There is emerging evidence that events occurring before and shortly after birth may be important in determining the risk of childhood‐onset type 1 diabetes mellitus (T1DM). We aimed to summarize and synthesize the associations between maternal body mass index (BMI), maternal diabetes mellitus (DM), and maternal smoking during pregnancy and the risk of childhood‐onset T1DM in the offspring by performing a systematic review and meta‐analysis of observational studies. A random effects model was used to generate the summary risk estimates. The PubMed and Web of Science databases were searched to identify relevant observational studies. Twenty one observational studies were included in the present meta‐analysis. Compared with offspring of mothers with normal weight, offspring of women with overweight or obesity were at an increased risk of developing childhood‐onset T1DM (overweight: relative risk [RR] 1.09, 95% confidence interval [CI], 1.03‐1.15; obesity: RR 1.25, 95% CI, 1.16‐1.34; per 5 kg m−2 increase in BMI: RR 1.10, 95% CI, 1.06‐1.13). No association was found for maternal underweight (RR 0.92, 95% CI, 0.75‐1.13). Maternal DM was associated with an increased risk of childhood‐onset T1DM (RR 3.26, 95% CI, 2.84‐3.74). Regarding the type of maternal DM, the greatest risk of T1DM in the offspring appeared to be conferred by maternal T1DM (RR 4.46, 95% CI, 2.89‐6.89), followed by maternal gestational diabetes mellitus (RR 1.66, 95% CI, 1.16‐2.36), and lastly by maternal type 2 diabetes mellitus (RR 1.11, 95% CI, 0.69‐1.80). Additional analysis of studies comparing maternal versus paternal T1DM within the same population revealed that offspring of fathers with T1DM had a 1.5 times higher risk of developing childhood‐onset T1DM than offspring of mothers with T1DM (RR 9.58, 95% CI, 6.33‐14.48 vs. RR 6.24, 95% CI, 5.52‐7.07). Furthermore, a reduced risk of childhood‐onset T1DM was observed in infants born to mothers who smoked during pregnancy compared with infants born to mothers who did not smoke during pregnancy (RR 0.79, 95% CI, 0.71‐0.87). In summary, our findings add further evidence that early‐life events or environmental factors may play a role in modulating infants' risk of developing T1DM later in life.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The influence of maternal body mass index, maternal diabetes mellitus, and maternal smoking during pregnancy on the risk of childhood‐onset type 1 diabetes mellitus in the offspring: Systematic review and meta‐analysis of observational studies

2019

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“…Previous studies suggested that obesity among parents is associated with obesity in children . Among those reports, a large scaled meta‐analysis, using individual data of prospective birth cohort in Europe and North America, reported that BMI of mothers is an important predictor of obesity in adolescence, rather than other pregnancy complications such as prenatal diabetes . Additionally, one study in Norway reported that girls were at a higher risk of the effect of obesity in mothers; however, the age reported for their study outcome was 7 years .…”

Section: Discussionmentioning

confidence: 99%

Association of maternal prepregnancy weight and early childhood weight with obesity in adolescence: A population‐based longitudinal cohort study in Japan

et al. 2020

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Summary Background The impact of birth weight and obesity in early childhood on obesity in adolescence remains unclear. Objectives To examine the association of overweight/obesity at age 15 years with birth weight, overweight/obesity in early childhood and overweight/obesity in mothers. Methods This population‐based retrospective cohort study used early childhood and school age health check‐up data of 1581 children in Japan, followed‐up until age 15 years. Generalized estimation equation analyses were used to investigate the association of overweight/obesity at age 15 years with low/high birth weight, overweight/obesity in 3 years of age and overweight/obesity in mothers. The cutoff points for all variables were defined by international criteria. Results Of 1581 mother‐child pairs, 130 (8.2%) children had low birth weight, while 93 (5.9%) and 167 (10.6%) were overweight/obese at age 3 and 15 years, respectively. Overweight/obesity at age 3 years and overweight/obesity in mothers were associated with overweight/obesity at age 15 years (adjusted odds ratio [aOR], 4.26; 95% confidence interval [CI]: 2.51–7.25 and (aOR, 2.46; 95% CI: 1.41–4.30). No association between low birth weight and overweight/obesity at age 15 years was observed. Conclusions Overweight/obesity in mothers and overweight/obesity at 3 years of age, but not birth weight, were associated with overweight/obesity at age 15 years.

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“…Epidemiological data from human catastrophes such as the Dutch famine (1944), the siege of Leningrad (1942Leningrad ( -1944, the great Chinese famine (1958)(1959)(1960)(1961), and the Överkalix study (1890-present) propose that changes in nutrient intake such as fasting or overnutrition during pregnancy and lactation are associated with metabolic and behavioral disorders in the offspring (Vaiserman, 2017). Maternal nutritional programing can influence offspring body weight, adiposity, and development of metabolic syndrome in diverse ways (Friedman, 2018;Patro Golab et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…For instance, nutritional programing adversely impacts both maternal and offspring health, increasing susceptibility to show metabolic abnormalities later in life such as obesity, dyslipidemia, type 2 diabetes (T2D) mellitus and hypertension, as well as behavioral disorders related to schizophrenia, autism, and compulsive eating (Shapiro et al, 2017;Friedman, 2018;Patro Golab et al, 2018;Derks et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Neurodegenerative Susceptibility During Maternal Nutritional Programing: Are Central and Peripheral Innate Immune Training Relevant?

et al. 2020

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Maternal overnutrition modulates body weight, development of metabolic failure and, potentially, neurodegenerative susceptibility in the offspring. Overnutrition sets a chronic pro-inflammatory profile that integrates peripheral and central immune activation nodes, damaging neuronal physiology and survival. Innate immune cells exposed to hypercaloric diets might experience trained immunity. Here, we address the role of maternal overnutrition as a trigger for central and peripheral immune training and its contribution to neurodegeneration and the molecular nodes implicated in the Nod-like receptor protein 3 (NLRP3) inflammasome pathway leading to immune training. We propose that maternal overnutrition leads to peripheral or central immune training that favor neurodegenerative susceptibility in the offspring.

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Influence of maternal obesity on the association between common pregnancy complications and risk of childhood obesity: an individual participant data meta-analysis

Abstract: EU's Horizon 2020 research and innovation programme (LifeCycle Project).

Cited by 107 publications

References 38 publications

The influence of maternal body mass index, maternal diabetes mellitus, and maternal smoking during pregnancy on the risk of childhood‐onset type 1 diabetes mellitus in the offspring: Systematic review and meta‐analysis of observational studies

The influence of maternal body mass index, maternal diabetes mellitus, and maternal smoking during pregnancy on the risk of childhood‐onset type 1 diabetes mellitus in the offspring: Systematic review and meta‐analysis of observational studies

Association of maternal prepregnancy weight and early childhood weight with obesity in adolescence: A population‐based longitudinal cohort study in Japan

Neurodegenerative Susceptibility During Maternal Nutritional Programing: Are Central and Peripheral Innate Immune Training Relevant?

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