Influence of maternal metabolic control and insulin antibodies on neonatal complications and B cell function in infants of diabetic mothers

Fallucca, F; Maldonato, A.; Iavicoli, M; Rollo, Giuseppe; Biase, Nicolina Di; Napoli, Angela; Vecchis, P. De; Sciullo, E.; Gerlini, G; Pachı́, A.

doi:10.1016/0168-8227(89)90016-8

Cited by 9 publications

(9 citation statements)

References 20 publications

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“…This finding is comparable with others studies that reported cord C-peptide levels were found to be inversely related to blood glucose concentration in early postnatal period 10,21,22 . But Mohajeri Tehrani et al 24 and Stenninger E et al 25 found association between cord C-peptide and macrosomia in IDMs but not with hypoglycemia.…”

Section: Fig-1: Graph Showing Blood Glucose Status Over 24 Hours Of supporting

confidence: 82%

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Relationship between Umbilical Cord C-peptide and Risk of Hypoglycemia in Infants of Diabetic Mothers

Begum¹,

Hassan²,

Azad

2012

Bangladesh J Child Health

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Section: Fig-1: Graph Showing Blood Glucose Status Over 24 Hours Of supporting

confidence: 82%

“…Similar finding also reported by Abdelgadir et al 20 , Goudard et al 21 , Fallucca F et al 22 . This significant difference of mean C-peptide value means that there may be an association between high C-peptide and risk of hypoglycemia in IDMs.…”

Section: Fig-1: Graph Showing Blood Glucose Status Over 24 Hours Of supporting

confidence: 80%

Relationship between Umbilical Cord C-peptide and Risk of Hypoglycemia in Infants of Diabetic Mothers

Begum¹,

Hassan²,

Azad

2012

Bangladesh J Child Health

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“…Some early studies suggested that IAs were associated with increases in neonatal morbidity, including hypoglycemia, respiratory distress syndrome, and hypocalcemia (304,310). However, studies in which pregnant women with diabetes were monitored for glycemic control argue against a connection between IAs and fetal risk.…”

Section: Discussionmentioning

confidence: 96%

“…The potential for increased incidences of neonatal hypoglycemia, respiratory distress syndrome, and hypocalcemia has also been suggested in small studies published from 1980 to 1990 (304,305,309,310); however, these reports also lacked adequate documentation of maternal glycemic control. Subsequent studies, performed in the modern era of prenatal care for women with diabetes, argue against a connection between IAs and fetal morbidities (254,311).…”

Section: Pregnancymentioning

confidence: 92%

Immunological Responses to Exogenous Insulin

et al. 2007

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Regardless of purity and origin, therapeutic insulins continue to be immunogenic in humans. However, severe immunological complications occur rarely, and less severe events affect a small minority of patients. Insulin autoantibodies (IAAs) may be detectable in insulin-naive individuals who have a high likelihood of developing type 1 diabetes or in patients who have had viral disorders, have been treated with various drugs, or have autoimmune disorders or paraneoplastic syndromes. This suggests that under certain circumstances, immune tolerance to insulin can be overcome. Factors that can lead to more or less susceptibility to humoral responses to exogenous insulin include the recipient's immune response genes, age, the presence of sufficient circulating autologous insulin, and the site of insulin delivery. Little proof exists, however, that the development of insulin antibodies (IAs) to exogenous insulin therapy affects integrated glucose control, insulin dose requirements, and incidence of hypoglycemia, or contributes to beta-cell failure or to long-term complications of diabetes. Studies in which pregnant women with diabetes were monitored for glycemic control argue against a connection between IAs and fetal risk. Although studies have shown increased levels of immune complexes in patients with diabetic microangiopathic complications, these immune complexes often do not contain insulin or IAs, and insulin administration does not contribute to their formation. The majority of studies have shown no relationship between IAs and diabetic angiopathic complications, including nephropathy, retinopathy, and neuropathy. With the advent of novel insulin formulations and delivery systems, such as insulin pumps and inhaled insulin, examination of these issues is increasingly relevant.

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“…In addition to the above-described clinical manifestations, clinical issues such as pregnancy and diabetic complications have been shown to be related to IAs. Some early studies suggested that IAs were associated with increases in neonatal morbidity, including hypoglycaemia, respiratory distress syndrome and hypocalcaemia ( 70 , 71 ). However, studies in which pregnant women with diabetes were monitored for glycaemic control argue against a relationship between IAs and foetal risk, with no distinguishing clinical characteristics of neonatal hypoglycaemia found to be associated with IAs ( 1 ).…”

Section: Clinical Significance Of Iasmentioning

confidence: 99%

Exogenous insulin antibody syndrome (EIAS): a clinical syndrome associated with insulin antibodies induced by exogenous insulin in diabetic patients

Chen

2018

Endocrine Connections

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Insulin has been used for diabetes therapy and has achieved significant therapeutic effect. In recent years, the use of purified and recombinant human insulin preparations has markedly reduced, but not completely suppressed, the incidence of insulin antibodies (IAs). IAs induced by exogenous insulin in diabetic patients is associated with clinical events, which is named exogenous insulin antibody syndrome (EIAS). The present review is based on our research and summarizes the characterization of IAs, the factors affecting IA development, the clinical significance of IAs and the treatments for EIAS.

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Influence of maternal metabolic control and insulin antibodies on neonatal complications and B cell function in infants of diabetic mothers

Cited by 9 publications

References 20 publications

Relationship between Umbilical Cord C-peptide and Risk of Hypoglycemia in Infants of Diabetic Mothers

Relationship between Umbilical Cord C-peptide and Risk of Hypoglycemia in Infants of Diabetic Mothers

Immunological Responses to Exogenous Insulin

Exogenous insulin antibody syndrome (EIAS): a clinical syndrome associated with insulin antibodies induced by exogenous insulin in diabetic patients

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