Influence of maternal endocrine disrupting chemicals exposure on adverse pregnancy outcomes: A systematic review and meta-analysis

Liu, Bin; Lu, Xiaoling; Jiang, Antong; Lv, Yanming; Zhang, Hongmei; Xu, Bin

doi:10.1016/j.ecoenv.2023.115851

Ecotoxicology and Environmental Safety

2024

DOI: 10.1016/j.ecoenv.2023.115851

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Influence of maternal endocrine disrupting chemicals exposure on adverse pregnancy outcomes: A systematic review and meta-analysis

Bin Liu,

Xiaoling Lu,

Antong Jiang

et al.

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2024

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Cited by 3 publications

References 120 publications

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Causes and Terminology in Neonatal Encephalopathy

Branagan,

Molloy,

Badawi

et al. 2024

Clinics in Perinatology

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Causes and Terminology in Neonatal Encephalopathy

Branagan,

Molloy,

Badawi

et al. 2024

Clinics in Perinatology

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Effect of prenatal phthalate exposure on fetal development and maternal/neonatal health consequences: A systematic review

Almeida-Toledano,

Navarro-Tapia,

Sebastiani

et al. 2024

Science of The Total Environment

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Perfluoroalkyl and Polyfluoroalkyl Substances in Relation to the Participant-Reported Total Pregnancy and Live Birth Numbers among Reproductive-Aged Women in the United States

Huang,

Li,

Zhou

et al. 2024

Toxics

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Perfluoroalkyl and polyfluoroalkyl substances (PFASs), widely utilized in various industries, may pose potential reproductive well-being risks. However, the research on the impact of PFAS exposures on pregnancy and live birth rates remains scarce. To address this gap, we conducted a cross-sectional study using the data from the United States National Health and Nutrition Examination Survey (NHANES) collected between 2013 and 2018. We focused on six PFAS compounds measured in the serum of women aged 20 to 50 years, employing the Poisson regression, Quantile G-composition (Qgcomp), and Weighted Quantile Sum (WQS) regression models. Adjusting for age, racial/ethnic origin, educational level, marital status, family income, body mass index (BMI), menarche age, birth control pill use, and other female hormone consumption, the Poisson regression identified significant negative associations between the individual PFAS exposures and pregnancy and live birth numbers (p < 0.05 for all 24 null hypotheses for which the slope of the trend line is zero). The Qgcomp analysis indicated that a one-quartile increase in the mixed PFAS exposures was associated with reductions of 0.09 (95% CI: −0.15, −0.03) in the pregnancy numbers and 0.12 (95% CI: −0.19, −0.05) in the live birth numbers. Similarly, the WQS analysis revealed that a unit increase in the WQS index corresponded to decreases of 0.14 (95% CI: −0.20, −0.07) in the pregnancy numbers and 0.14 (95% CI: −0.21, −0.06) in the live birth numbers. Among the six specific PFAS compounds we studied, perfluorononanoic acid (PFNA) had the most negative association with the pregnancy and live birth numbers. In conclusion, our findings suggest that PFAS exposures are associated with lower pregnancy and live birth numbers among women of reproductive age.

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Influence of maternal endocrine disrupting chemicals exposure on adverse pregnancy outcomes: A systematic review and meta-analysis

Cited by 3 publications

References 120 publications

Causes and Terminology in Neonatal Encephalopathy

Causes and Terminology in Neonatal Encephalopathy

Effect of prenatal phthalate exposure on fetal development and maternal/neonatal health consequences: A systematic review

Perfluoroalkyl and Polyfluoroalkyl Substances in Relation to the Participant-Reported Total Pregnancy and Live Birth Numbers among Reproductive-Aged Women in the United States

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