Influence of Maternal Breast Milk and Vaginal Microbiome on Neonatal Gut Microbiome: a Longitudinal Study during the First Year

Bhattacharyya, Chandrika; Barman, Diganta; Tripathi, Devashish; Dutta, Soumita; Bhattacharya, Chandra; Alam, Mahabub; Choudhury, Parveena; Devi, Utpala; Mahanta, Jagadish; Rasaily, Reeta; Basu, Analabha; Paine, Suman Kalyan

doi:10.1128/spectrum.04967-22

Cited by 3 publications

(1 citation statement)

References 27 publications

(27 reference statements)

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“…Establishing maternal microbiota in neonates is crucial to their growth and well-being (Bhattacharyya et al, 2023). A scientific research team comprising multiple centers in the United States has discovered that neonates delivered via cesarean section can partially restore their intestinal microbiota by being swabbed with maternal vaginal microbes immediately after birth (Dominguez-Bello et al, 2016).…”

Section: Treatment With Antibiotics and Vmt Slows The Development Of ...mentioning

confidence: 99%

Vaginal microbiota transplantation is a truly opulent and promising edge: fully grasp its potential

Meng,

Sun,

Zhang

2024

Front. Cell. Infect. Microbiol.

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Vaginal microbiota transplantation (VMT) is a cutting-edge treatment modality that has the potential to revolutionize the management of vaginal disorders. The human vagina is a complex and dynamic ecosystem home to a diverse community of microorganisms. These microorganisms play a crucial role in maintaining the health and well-being of the female reproductive system. However, when the balance of this ecosystem is disrupted, it can lead to the development of various vaginal disorders. Conventional treatments, such as antibiotics and antifungal medications, can temporarily relieve the symptoms of vaginal disorders. However, they often fail to address the underlying cause of the problem, which is the disruption of the vaginal microbiota. In recent years, VMT has emerged as a promising therapeutic approach that aims to restore the balance of the vaginal ecosystem. Several studies have demonstrated the safety and efficacy of VMT in treating bacterial vaginosis, recurrent yeast infections, and other vaginal conditions. The procedure has also shown promising results in reducing the risk of sexually transmitted infections and preterm birth in pregnant women. However, more research is needed to establish optimal donor selection, preparation, and screening protocols, as well as long-term safety and efficacy. VMT offers a safe, effective, and minimally invasive treatment option for women with persistent vaginal problems. It could improve the quality of life for millions of women worldwide and become a standard treatment option shortly. With further research and development, it could potentially treat a wide range of other health problems beyond the scope of vaginal disorders.

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Section: Treatment With Antibiotics and Vmt Slows The Development Of ...mentioning

confidence: 99%

Vaginal microbiota transplantation is a truly opulent and promising edge: fully grasp its potential

Meng,

Sun,

Zhang

2024

Front. Cell. Infect. Microbiol.

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The effect of in-hospital breast milk intake on the gut microbiota of preterm infants

Yang,

Wang,

Chen

et al. 2024

Clinical Nutrition ESPEN

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Maternal Psychological Well-Being as a Protector in Infantile Colic

Garnacho-Garnacho,

Rodríguez-López,

Oliva-Pascual-Vaca

et al. 2024

Nutrients

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(1) Background: Infantile colic (IC) is a functional gastrointestinal disorder that affects around 20% of infants, and postpartum (PPD) depression is a common disorder that affects between 15 and 22% of mothers. In this study, our objective was to evaluate the relationship between the maternal psychological state in the first postpartum year and IC, with the aim of assessing the importance of feeding type in infants and maternal well-being. (2) Methods: A cross-sectional study was conducted in women in their first year postpartum. Demographic, medical, and obstetric data of the mothers and infants were collected, and the type of feeding was identified. The emotional status of the mother was evaluated using the Edinburgh Postnatal Depression Scale (EPDS), and the Infant Colic Severity Questionnaire (ICSQ) was used for IC diagnosis. (3) Results: A total of 528 women were analyzed, of which 170 (32%) were diagnosed with possible PPD. Two-thirds of the women without depression breastfed their babies on demand; therefore, we report that exclusive breastfeeding (EBF) appears to reduce the risk of possible PPD (p < 0.001; OR = 2.353). IC was present in 39% of babies, and around 70% of babies without colic were breastfed on demand. Infants who were not exclusively breastfed showed almost double the risk of developing colic (p = 0.016; OR = 1.577). There was a significant association between the EPDS and ICSQ scores (p < 0.001). More than half of the women with PPD had babies with colic. However, our results show that 75% of babies without colic had mothers who reported optimal postpartum emotional well-being (p < 0.001; OR = 2.105). (4) Conclusions: The results of this study suggest that postpartum maternal psychological well-being reduces the risk of IC. Therefore, we report that EBF on demand, together with a healthy emotional state in new mothers, may be a protective factor against colic in infants.

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Influence of Maternal Breast Milk and Vaginal Microbiome on Neonatal Gut Microbiome: a Longitudinal Study during the First Year

Abstract: Gut microbiome architecture seems to have a potential impact on host metabolism, health, and nutrition. Early life gut microbiome development is considered a crucial phenomenon for neonatal health as well as adulthood metabolic complications.

Cited by 3 publications

References 27 publications

Vaginal microbiota transplantation is a truly opulent and promising edge: fully grasp its potential

Vaginal microbiota transplantation is a truly opulent and promising edge: fully grasp its potential

The effect of in-hospital breast milk intake on the gut microbiota of preterm infants

Maternal Psychological Well-Being as a Protector in Infantile Colic

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