Influence of maternal antibodies on active pertussis toxoid immunization of neonatal mice and piglets

Polewicz, Monika; Gracia, Aleksandra; Buchanan, Rachelle; Strom, Stacy; Halperin, Scott A.; Potter, Andrew; Babiuk, Lorne A.; Gerdts, Volker

doi:10.1016/j.vaccine.2011.07.135

Cited by 35 publications

(17 citation statements)

References 49 publications

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“…Changes in regulatory processes to allow rapid replacement of HA and NA on approved IAV backbones or platforms would also be extremely useful for improving control measures against influenza A virus in swine. Additionally, platforms not currently available in swine, such as live attenuated influenza vaccines or vectored vaccines, have shown great promise in experimental settings for improved heterologous protection and greater efficacy in the face of maternally derived antibodies (44,(49)(50)(51)(52)(53)(54).…”

Section: Discussionmentioning

confidence: 99%

Substitutions near the Hemagglutinin Receptor-Binding Site Determine the Antigenic Evolution of Influenza A H3N2 Viruses in U.S. Swine

Lewis

Anderson

Kitikoon

et al. 2014

J Virol

122

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Swine influenza A virus is an endemic and economically important pathogen in pigs, with the potential to infect other host species. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major component in swine influenza A vaccines. However, as a result of antigenic drift, vaccine strains must be regularly updated to reflect currently circulating strains. Characterizing the cross-reactivity between strains in pigs and seasonal influenza virus strains in humans is also important in assessing the relative risk of interspecies transmission of viruses from one host population to the other. Hemagglutination inhibition (HI) assay data for swine and human H3N2 viruses were used with antigenic cartography to quantify the antigenic differences among H3N2 viruses isolated from pigs in the United States from 1998 to 2013 and the relative cross-reactivity between these viruses and current human seasonal influenza A virus strains. Two primary antigenic clusters were found circulating in the pig population, but with enough diversity within and between the clusters to suggest updates in vaccine strains are needed. We identified single amino acid substitutions that are likely responsible for antigenic differences between the two primary antigenic clusters and between each antigenic cluster and outliers. The antigenic distance between current seasonal influenza virus H3 strains in humans and those endemic in swine suggests that population immunity may not prevent the introduction of human viruses into pigs, and possibly vice versa, reinforcing the need to monitor and prepare for potential incursions. IMPORTANCEInfluenza A virus (IAV) is an important pathogen in pigs and humans. The hemagglutinin (HA) protein is the primary target of protective immune responses and the major target of vaccines. However, vaccine strains must be updated to reflect current strains. Characterizing the differences between seasonal IAV in humans and swine IAV is important in assessing the relative risk of interspecies transmission of viruses. We found two primary antigenic clusters of H3N2 in the U.S. pig population, with enough diversity to suggest updates in swine vaccine strains are needed. We identified changes in the HA protein that are likely responsible for these differences and that may be useful in predicting when vaccines need to be updated. The difference between human H3N2 viruses and those in swine is enough that population immunity is unlikely to prevent new introductions of human IAV into pigs or vice versa, reinforcing the need to monitor and prepare for potential introductions.

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Section: Discussionmentioning

confidence: 99%

Substitutions near the Hemagglutinin Receptor-Binding Site Determine the Antigenic Evolution of Influenza A H3N2 Viruses in U.S. Swine

Lewis

Anderson

Kitikoon

et al. 2014

J Virol

122

View full text Add to dashboard Cite

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“…In 2014, Jiménez-Truquehas and Edwards (558) summarized those concerns as follows: (i) the safety profile of Tdap vaccine for both mothers and babies has not been extensively evaluated, (ii) the high concentration of antibodies transmitted transplacentally could minimize an infant's immune response to pertussis-containing vaccine (559), and (iii) serological interference between maternal antibodies and infant antibodies after pertussis-containing vaccine can occur (553). More recent comments about the ACIP recommendations were provided by Boyce and Virk (534), who expressed concern that passive antipertussis immunity will not allow for sufficient herd immunity to protect infants from community exposures.…”

Section: Tdap Immunization For Pregnant Womenmentioning

confidence: 99%

Pertussis: Microbiology, Disease, Treatment, and Prevention

et al. 2016

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SUMMARYPertussis is a severe respiratory infection caused byBordetella pertussis, and in 2008, pertussis was associated with an estimated 16 million cases and 195,000 deaths globally. Sizeable outbreaks of pertussis have been reported over the past 5 years, and disease reemergence has been the focus of international attention to develop a deeper understanding of pathogen virulence and genetic evolution ofB. pertussisstrains. During the past 20 years, the scientific community has recognized pertussis among adults as well as infants and children. Increased recognition that older children and adolescents are at risk for disease and may transmitB. pertussisto younger siblings has underscored the need to better understand the role of innate, humoral, and cell-mediated immunity, including the role of waning immunity. Although recognition of adult pertussis has increased in tandem with a better understanding ofB. pertussispathogenesis, pertussis in neonates and adults can manifest with atypical clinical presentations. Such disease patterns make pertussis recognition difficult and lead to delays in treatment. Ongoing research using newer tools for molecular analysis holds promise for improved understanding of pertussis epidemiology, bacterial pathogenesis, bioinformatics, and immunology. Together, these advances provide a foundation for the development of new-generation diagnostics, therapeutics, and vaccines.

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“…A potential concern of maternal immunization during pregnancy is that high levels of MatAbs might have a negative effect on the infant's own ability to mount antibody response to primary DTaP vaccination [4,85,102]. MatAbs interfere with infant immunization by binding specific vaccine epitopes and, thus, preventing their interaction with infant B cells [102].…”

Section: Matabs Interference With Primary Pertussis Vaccinationmentioning

confidence: 99%

Management and prevention of pertussis infection in neonates

Berti

Venturini

Galli

et al. 2014

Expert Review of Anti-infective Therapy

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Despite the fact that universal immunization against pertussis led to a dramatic decrease in the incidence and mortality in high-income countries, it has left a window of vulnerability for newborns. Although specific guidelines concerning management of neonatal whooping cough have not yet been developed, the present review summarizes the main available recommendations on diagnostic work-up and treatment of neonatal pertussis. Additionally, new prevention strategies are explored, including the use of an additional booster dose of vaccine to adolescents and adults, vaccination of healthcare workers, immunization of household contacts and caregivers (cocooning strategy), vaccination of pregnant women and, finally, neonatal immunization with novel vaccines. These strategies are analyzed and discussed in terms of efficacy, safety and cost-effectiveness.

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Influence of maternal antibodies on active pertussis toxoid immunization of neonatal mice and piglets

Cited by 35 publications

References 49 publications

Substitutions near the Hemagglutinin Receptor-Binding Site Determine the Antigenic Evolution of Influenza A H3N2 Viruses in U.S. Swine

Substitutions near the Hemagglutinin Receptor-Binding Site Determine the Antigenic Evolution of Influenza A H3N2 Viruses in U.S. Swine

Pertussis: Microbiology, Disease, Treatment, and Prevention

Management and prevention of pertussis infection in neonates

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