Influence of mastitis metritis agalactia (MMA) on bone and fat metabolism

Abstract

Influence of mastitis metritis agalactia (MMA) on bone and fat metabolismInaugural-Dissertation zur Erlangung der Doktorwürde der Abstract 4Zusammenfassung 5 References 19Danksagung Curriculum Vitae AbstractMastitis metritis agalactia (MMA) is a common disease in postpartum sows and has a negative effect on sows' longevity as well as on sows' and piglets' health. Since MMA often leads to reduced feed intake and an inflammatory state in general, which is known to affect bone metabolism, the aim of this study was to investigate the impact of MMA on bone and fat metabolism. The hypothesis was that it is possible to predict MMA by measuring ketone bodies and bone turnover markers. Blood samples from 175 sows (100 healthy & 75 MMA sows) were taken within 72 h after farrowing. Serum was analysed for 25-0H-D, CTX-l, OC, ALP, Ca, Mg, P, PTH, triglycerides, BHB, leptin, TNF-α, IL-6 and haptoglobin. MMA sows had a poorer BCS (p < 0.001) compared to healthy sows. MMA sows showed catabolic bone metabolism (increased serum CTX-I (p = 0.004), decreased serum OC (p < 0.001)). Concentrations of serum P (p = 0.007), activity of ALP (p = 0.002), and serum BHB concentrations (p = 0.019) as well as serum concentration of TNF-α (p < 0.001) and haptoglobin (p = 0.048) were increased in MMA sows. Serum Mg concentrations (p < 0.001) were decreased. Our results are in accordance with the known fact that sows are in an extreme catabolic state peripartum. This study demonstrates that bone metabolism in MMA sows is much more negatively affected than in healthy sows postpartum, due to inflammatory processes shown by higher concentrations of pro-inflammatory cytokines.

The action of Choriocene on hypogalactic parturient sows

“…Maladia apare la scroafe, de obicei, în primele zile de la parturiţie, dar sunt descrise şi cazuri când această stare survine şi mai târziu [11,12,13]. Se consideră că în suprimarea procesului de secreție a laptelui pot fi implicaţi numeroşi factori patogeni, dar în majoritatea cazurilor, simptomele clinice prin care se exprimă maladia sunt similare [14,15,16,17].…”

Evaluation of zootechnical parameters of piglets born and suckled from dams treated with a non-steroidal anti-inflammatory drug after farrowing

“…Farrowing is a precarious process that can potentially lead to a wide range of conditions in dams and their offspring ( Mainau et al , 2016 ; Ison et al , 2017 ). These can include inflammatory conditions such as mastitis metritis agalactia (MMA) ( Karst et al , 2021 ), endotoxemia ( I.S.U., 2022 ), pain associated with parturition, and sore nipples, which can cause dams to become more aggressive and less receptive to suckling ( Albáñez et al , 2019 ). These conditions are common, multifactorial, and may be difficult to diagnose under on-farm conditions (e.g., MMA).…”

Effect of supplementing sows with <i>Solanum glaucophyllum</i>, a natural source of calcitriol, on farrowing performance, piglet survival and litter performance

“…In addition, any condition inducing renal failure or lowering the circulating level of parathyroid hormone may reduce the conversion of calcidiol to calcitriol. In sows, the occurrence of mastitis-metritis-agalactia syndrome was associated with low blood calcidiol concentrations (Karst et al, 2019). Supplementing gestating and lactating sows with calcidiol consistently increased serum calcidiol level but effects on piglet survival and performance were inconsistent (Flohr et al, 2016;Upadhaya et al, 2021).…”