Active commuting (AC; walking and biking to work) is associated with significant health benefits. AC rates remain low in the United States, particularly among parents; accordingly, it is important to understand factors associated with AC for potential intervention development. The purpose of this study was to examine the multi-level influences of AC participation in parents who are currently regular active commuters. At the individual level, the benefits of exercise, enjoyment of AC, and the use of child-friendly bicycle accessories facilitated AC; however, time and effort were also shown to impede AC. Positive interpersonal influences included spousal support and scheduling, an AC supportive work environment, and interest from the children, whereas negative influences included childcare and time for travel to school. Environmental factors (i.e., weather, terrain, distance, and infrastructure) appeared to both support and inhibit AC. These findings from successful active commuters may be used to inform future AC interventions.