Influence of Marijuana Potency and Amount of Cigarette Consumed on Marijuana Smoking Pattern

Wu, Tzu‐Chin; Tashkin, Donald P.; Rose, Jed E.; Djahed, Benham

doi:10.1080/02791072.1988.10524370

Cited by 22 publications

(10 citation statements)

References 5 publications

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“…This was also consistent with another study that showed decreases in puff volume during the second half of a cannabis cigarette compared to the first half of the cigarette (Wu et al 1988b). Time to peak velocity also decreased throughout the course of the cigarette, while puff velocity increased throughout the cigarette.…”

Section: Discussionsupporting

confidence: 92%

Characterizing smoking topography of cannabis in heavy users

2011

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Rationale Little is known about the smoking topography characteristics of heavy cannabis users. Such measures may be able to predict cannabis use-related outcomes and could be used to validate self-reported measures of cannabis use. Objectives The current study was conducted to measure cannabis smoking topography characteristics during periods of ad libitum use and to correlate topography assessments with measures of self-reported cannabis use, withdrawal and craving during abstinence, and cognitive task performance. Methods Participants (N=20) completed an inpatient study in which they alternated between periods of ad libitum cannabis use and abstinence. Measures of self-reported cannabis use, smoking topography, craving, withdrawal, and sleep measures were collected. Results Participants smoked with greater intensity (e.g., greater volume, longer duration) on initial cigarette puffs with a steady decline on subsequent puffs. Smoking characteristics were significantly correlated with severity of withdrawal, notably sleep quality and architecture, and craving during abstinence, suggesting dose-related effects of cannabis use on these outcomes. Smoking characteristics generally were not significantly associated with cognitive performance. Smoking topography measures were significantly correlated with self-reported measures of cannabis use, indicating validity of these assessments, but topography measures were more sensitive than self-report in predicting cannabis-related outcomes. Conclusions A dose–effect relationship between cannabis consumption and outcomes believed to be clinically important was observed. With additional research, smoking topography assessments may become a useful clinical tool.

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Section: Discussionsupporting

confidence: 92%

Characterizing smoking topography of cannabis in heavy users

2011

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“…Studies using marijuana cigarettes with maximal THC contents ranging from 1.24 to 2.54% did not observe a significant titration of THC intake (e.g., Cappell et al, 1973;Perez-Reyes et al, 1982;Wu et al, 1988;Chait, 1989;Kelly et al, 1994a), while studies which observed a significant titration of THC intake used cigarettes with maximal THC contents ranging from 3.9 to 4.0% (Herning et al, 1986;Nemeth-Coslett et al, 1986). It appears that the ability of subjects to discriminate between different dose levels of THC might affect their marijuana smoking behavior.…”

Section: Self-administration Of Cannabinoids In Human Subjectsmentioning

confidence: 92%

“…During the following quarter century, scientists attempted, mostly with little success, to further demonstrate a THC dose-regulation phenomenon with smoked marijuana (Ashton et al, 1981;Perez-Reyes et al, 1982;Wu et al, 1988;Chait, 1989;Zacny and de Wit, 1991;Kelly et al, 1994a, but see also: Azorlosa et al, 1992;Harder and Rietbrock, 1997;Block et al, 1998). However, Herning and colleagues (1986) observed that experienced marijuana smokers took significantly more puffs with longer intervals between puffs while smoking high potency (3.9% THC) compared to low potency (1.2% THC) marijuana cigarettes and they also inhaled substantially larger (46%) volumes of air.…”

Section: Self-administration Of Cannabinoids In Human Subjectsmentioning

confidence: 99%

Self-administration of cannabinoids by experimental animals and human marijuana smokers

Justinová

Goldberg

Heishman

2005

Pharmacology Biochemistry and Behavior

115

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Drug self-administration behavior has been one of the most direct and productive approaches for studying the reinforcing effects of psychoactive drugs, which are critical in determining their abuse potential. Cannabinoids, which are usually abused by humans in the form of marijuana, have become the most frequently abused illicit class of drugs in the United States. The early elucidation of the structure and stereochemistry of delta-9-tetrahydrocannabinol (THC) in 1964, which is now recognized as the principal psychoactive ingredient in marijuana, activated cannabinoid research worldwide. This review examines advances in research on cannabinoid self-administration behavior by humans and laboratory animals. There have been numerous laboratory demonstrations of the reinforcing effects of cannabinoids in human subjects, but reliable self-administration of cannabinoids by laboratory animals has only recently been demonstrated. It has now been shown that strong and persistent self-administration behavior can be maintained in experimentally and drugnaïve squirrel monkeys by doses of THC comparable to those in marijuana smoke inhaled by humans. Furthermore, reinforcing effects of some synthetic CB 1 cannabinoid agonists have been recently reported using intravenous and intracerebroventricular self-administration procedures in rats and mice. These findings support previous conclusions that THC has a pronounced abuse liability comparable to other drugs of abuse under certain experimental conditions. Self-administration of THC by squirrel monkeys provides the most reliable animal model for human marijuana abuse available to date. This animal model now makes it possible to study the relative abuse liability of other natural and synthetic cannabinoids and to preclinically assess new therapeutic strategies for the treatment or prevention of marijuana abuse in humans.

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“…Some earlier studies suggested that they could 41 but more recent studies report that cannabis users have limited ability to titrate their dose of THC 42,43 so the issue has not yet been resolved.…”

Section: What Are the Health Implications Of Any Increase In Thc Contmentioning

confidence: 99%