Influence of Malnutrition in Early Life on Exploratory Behavior of Rats

Franková, S; Rh, Barnes

doi:10.1093/jn/96.4.477

Cited by 104 publications

(18 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increase in exploratory activity has been reported in rat offspring after maternal protein restriction during lactation period (Franková and Barnes, 1968). Pre-and/or postnatal protein restriction in rats increased open arm entries, time and distance in elevated plus maze test, suggesting decreased avoidance (less anxiety) and increased exploration (Reyes-Castro et al, 2011).…”

Section: Discussionmentioning

confidence: 95%

Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats

et al. 2012

View full text Add to dashboard Cite

-To clarify the effect of systemic growth retardation on behavior, pregnant rats were fed a synthetic diet with either a normal (20% casein) or low (10% casein) protein concentration from gestational day 10 to postnatal day (PND) 21 at weaning. Offspring were examined for sensory and reflex functions, detailed clinical observations, manipulative test, grip strength, motor activity and water-filled multiple T-maze test. Lowering trend in the air righting reflex index during lactation period and a decrease in grip strength on PND 72 were observed in the low protein diet group showing suppression of systemic growth. However, they were simply the reflection of delayed systemic growth, because parameters on impaired reflex function, disturbance of motor function and paralysis were unaffected. On the other hand, low protein diet resulted in increased motor activity in female offspring. Thus, malnutrition due to maternal protein restriction may cause adolescent hyperactivity.

show abstract

Section: Discussionmentioning

confidence: 95%

Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats

et al. 2012

View full text Add to dashboard Cite

show abstract

“…results of experimental phenylketonuria should be contrasted with those of experimental malnutrition, since the actual agent of injury in experimental phenylketonuria might plausibly be an undernourishment secondary to the noxious effects of the injections. When this comparison is made, subjects with experimental malnutrition are noted to be less active, not more active, than normal rats when they are refed (13) and are permanently decreased in weight (14). Another question is whether our model produces in the experimental subject changes not found in clinical phenylketonuria.…”

Section: Discussionmentioning

confidence: 96%

Enduring Behavioral Changes in Rats with Experimental Phenylketonuria

Andersen

Guroff

1972

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Several criticisms of past attempts to produce experimental phenylketonuria are discussed, and a model that appears to meet these criticisms is presented. This model uses inhibition in rats of phenylalanine hydroxylase (EC 1.14.3.1) by p-chlorophenylalanine and supplementation with phenylalanine to produce a high ratio of phenylalanine to tyrosine in their blood. By this method, an experimental subject is produced whose behavioral, neurological, and biochemical characteristics are similar to those of clinical patients with phenylketonuria.

show abstract

“…The growth curves from one of these comparisons (DNOQ vs. DOOQ) is shown in figure 1. A decrease in final body weight (9,8, and 11% for groups T 1; T2, and T3, respectively) was evident for all pups nursing asparagine-de prived dams. This decrease was caused at least partially by a growth deficit in the pups that immediately followed dietary asparagine deprivation of their dams.…”

Section: Growth Responsesmentioning

confidence: 89%

“…Smart and Dobbing [32] de termined that maternal food restriction dur ing lactation alone reduced the numberof up ward responses of their pups in an open field (vertical exploratory behavior) and also ad versely affected their balancing ability. Frankovci and Barnes [9] reported a decrease in the exploratory behavior of pups w'ho nursed dams fed a low protein diet. Mice reared in large litters, and thus malnour ished, displayed deficits in avoidance learn ing that persisted even after nutritional reha bilitation [15].…”

Section: Introductionmentioning

confidence: 99%

Brain Development in Neonatal Rats Nursing Asparagine-Deprived Dams

Newburg

Fillios

1982

Dev Neurosci

View full text Add to dashboard Cite

A possible requirement for dietary asparagine during lactation was investigated by measuring any adverse effect of maternal asparagine deprivation on the body growth and brain development of nursing rat pups. Each dam was given 7 pups to nurse. Three groups of 5 dams each were deprived from the 1st (T₁), 8th (T₂), or 15th (T₃) day of lactation until weaning (day 22); at weaning, the pups of each group weighed approximately 10% less than those of asparagine-fed controls. Brain development was also affected: the cerebra of T₃ pups contained less cholesterol and cerebrosides than control pups, indicating decreased myelination. Both T₂and T₃ pups required more trials in a water maze to acquire a learned behavior than control pups. T₁, T₂, and T₃ pups also displayed higher seizure thresholds. The groups of pups whose brains contained the lowest amounts of myelin lipids (T₃) were those who displayed the greatest deviation in behavior from the control pups. Thus, the development of neonatal rat brain is sensitive to even mild or transient forms of malnutrition, and a requirement for dietary asparagine during lactation seems evident.

show abstract

Influence of Malnutrition in Early Life on Exploratory Behavior of Rats

Cited by 104 publications

References 12 publications

Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats

Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats

Enduring Behavioral Changes in Rats with Experimental Phenylketonuria

Brain Development in Neonatal Rats Nursing Asparagine-Deprived Dams

Contact Info

Product

Resources

About