Influence of Malaria Edemicity and TB Prevalence on COVID-19 Mortality

Tf, Raham

doi:10.2139/ssrn.3698858

Cited by 1 publication

(1 citation statement)

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“…Recent studies have pointed to a potential protective effect of P. falciparum infections against SARS-CoV-2 infection, although direct experimental evidence is yet to be established (Iesa et al, 2020;Kalungi et al, 2021;Panda et al, 2020;Raham, 2021). The MERS-CoV RBM was also found to resemble the rhoptry neck protein 2 and thrombospondin-related anonymous protein from P. falciparum.…”

Section: Exogenousmentioning

confidence: 99%

Predicted structural mimicry of spike receptor-binding motifs from highly pathogenic human coronaviruses

Beaudoin

Jamasb

Alsulami

et al. 2021

Preprint

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SummaryViruses often encode proteins that mimic host proteins in order to facilitate infection. Little work has been done to understand the potential mimicry of the SARS-CoV-2, SARS-CoV, and MERS-CoV spike proteins, particularly the receptor-binding motifs, which could be important in determining tropism of the virus. Here, we use structural bioinformatics software to characterize potential mimicry of the three coronavirus spike protein receptor-binding motifs. We utilize sequence-independent alignment tools to compare structurally known or predicted three-dimensional protein models with the receptor-binding motifs and verify potential mimicry with protein docking simulations. Both human and non-human proteins were found to be similar to all three receptor-binding motifs. Similarity to human proteins may reveal which pathways the spike protein is co-opting, while analogous non-human proteins may indicate shared host interaction partners and overlapping antibody cross-reactivity. These findings can help guide experimental efforts to further understand potential interactions between human and coronavirus proteins.HighlightsPotential coronavirus spike protein mimicry revealed by structural comparisonHuman and non-human protein potential interactions with virus identifiedPredicted structural mimicry corroborated by protein-protein dockingEpitope-based alignments may help guide vaccine effortsGraphical abstract

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Section: Exogenousmentioning

confidence: 99%