Influence of Major Postoperative Complications on Health-Related Quality of Life Among Long-Term Survivors of Esophageal Cancer Surgery

Derogar, Maryam; Orsini, Nicola; Sadr–Azodi, Omid; Lagergren, Pernilla

doi:10.1200/jco.2011.40.3568

Cited by 183 publications

(161 citation statements)

References 41 publications

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“…96,105,106 Early postoperative complications, however, have profound negative effects both in the short and long term. 107 A recent population-based cohort study found that several HRQOL measures are strongly negatively affected up until 10 years after surgery, e.g. reflux, dysphagia and eating difficulties (Figure 4).…”

Section: Survivorshipmentioning

confidence: 97%

Oesophageal cancer

et al. 2017

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SummaryOesophageal cancer is a clinically challenging disease requiring a multidisciplinary approach.The extensive treatment may be associated with serious limitations in health-related quality of life and yet still a poor prognosis. Recent decades have witnessed a gradual improvement in prognosis in many countries. Endoscopic procedures have increasingly been used in the treatment of premalignant and early oesophageal tumours. Neoadjuvant therapy with chemotherapy or chemoradiotherapy has supplemented surgery as standard treatment of locally advanced oesophageal cancer. Surgery has become more standardised and centralised. There are several therapeutic alternatives for palliative treatment. This review aims to provide insights into the current clinical management, on-going controversies and future needs in oesophageal cancer.3

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Section: Survivorshipmentioning

confidence: 97%

Oesophageal cancer

et al. 2017

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“…Along with clinical care, psychosocial intervention amongst cancer patients is very essential to combat the shock and despair after initial diagnosis. It has been indicated that the patient's QOL after surgery not only depends on remaining symptoms or the severity of the disease after surgery, but on the patients' ability to take control and handle the new life situation [19][20][21] . Furthermore, most of the earlier studies have used data from a homogenous sample of patients with stringent exclusion criteria [15,18,23] .…”

Section: Discussionmentioning

confidence: 99%

EORTC QLQ-OES 18 module strategy for assessment of quality of life in esophageal cancer patients

Sehgal¹,

Gupta²,

Kaul³

et al. 2017

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“…Esophagectomy is the mainstay of treatment for curative intent of local and locally-advanced esophageal cancer (3)(4)(5). Multimodality therapy including esophagectomy is the standard of care in locally-advanced cancer (6).…”

Section: Introductionmentioning

confidence: 99%

“…However, the procedure itself is complex and morbid with up to 10% postoperative mortality (6). Furthermore, the evidence suggests that up to 50% of patients will experience postoperative complications within the first month of surgery (3)(4)(5). Recurrences can occur within the first year following surgery.…”

Section: Introductionmentioning

confidence: 99%

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Quality of life assessment in esophagectomy patients

et al. 2018

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Esophagectomy is the mainstay of curative therapy for esophageal cancer; however, it is associated with significant morbidity and mortality, with subsequent major impact on quality of life. This paper reviews the evaluation of health-related quality of life (HRQOL) in esophageal cancer patients undergoing curative intent therapy, the relationship between postoperative HRQOL and survival as well the potential utility of pre-treatment HRQOL as a prognostic tool. HRQOL assessment is valuable in helping clinicians understand the impact on patients of esophageal cancer and the various treatments thereof.HRQOL is also valuable as an end-point in studies of esophageal cancer and esophageal cancer treatment.Given the morbidity and mortality associated with the various treatments for esophageal cancer, it could be argued that HRQOL is as important an endpoint as survival, if not more so. Patient-reported pre-treatment HRQOL assessment appears to predict survival better than clinician-derived performance status assessment period. HRQOL assessment also appears to be responsive to surgical and non-surgical therapy and thus could potentially be used in trials and in practice to serve that function. Thus, HRQOL assessment could be a potentially important adjunct in shared decision-making and guiding treatment planning as well as monitoring the progress of treatment.

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Influence of Major Postoperative Complications on Health-Related Quality of Life Among Long-Term Survivors of Esophageal Cancer Surgery

Abstract: The occurrence of postoperative complications exerts a long-lasting negative effect on HRQL in patients who survive 5 years after esophagectomy for cancer.

Cited by 183 publications

References 41 publications

Oesophageal cancer

Oesophageal cancer

EORTC QLQ-OES 18 module strategy for assessment of quality of life in esophageal cancer patients

Quality of life assessment in esophagectomy patients

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