Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes

Sales, Cristiane Hermes; Pedrosa, Lúcia Fátima Campos; Lima, Josivan Gomes de; Lemos, Telma Maria Araújo Moura; Colli, Célia

doi:10.1016/j.clnu.2010.12.011

Cited by 70 publications

(43 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…19 Serum levels of magnesium have been found by several investigators to correlate inversely with fasting blood glucose concentration, post prandial blood glucose and the percentage of HbA1C. 8,20,[22][23][24][25] The present study also revealed that patients with low serum magnesium levels had poor glycemic control. There was statistically significant association between low serum magnesium levels and higher FBS, PPBS and HbA1C%.…”

Section: Discussionsupporting

confidence: 55%

Study of serum magnesium level in patients with type 2 diabetes mellitus and it’s correlation with glycosylated hemoglobin and diabetic complications

et al. 2017

View full text Add to dashboard Cite

INTRODUCTIONThe term diabetes mellitus (DM, derived from Greek words meaning -Siphon and sweet) refers to a group of common metabolic disorders that share the phenotype of hyperglycemia which results from reduced insulin secretion and/or action, decreased glucose utilization, and increased glucose production. Incidence of diabetes is increasing worldwide due to population ageing and growth, obesity, unhealthy diets and sedentary life style. Microvascular and macrovascular complications of diabetes increase as a function of the duration of hyperglycemia. So, a reduction of chronic hyperglycemia prevents or delays these complications. 1Magnesium is an essential element and has a fundamental role in carbohydrate metabolism in general and in the insulin action in particular. Magnesium is a cofactor in ABSTRACT Background: Hypomagnesemia has been proposed as a novel factor implicated in the pathogenesis of poor glycemic control and diabetic complications. Aim of the present study is to study serum magnesium level in patients with type 2 DM and to find the correlation between serum magnesium levels, HbA1c and diabetic complications. Methods: 100 patients with Type 2 DM (50 males and 50 females) who were diagnosed on the basis of ADA criteria or taking treatment for Diabetes were included in the study. All patients underwent tests for serum magnesium level, fasting blood sugar, postprandial blood sugar, HbA1c and also target organ evaluation for Diabetes. A detailed history and examination was also done. Results: There was significant difference in the prevalence of hypomagnesemia (34% versus 6%) and serum magnesium levels (1.59±0.187 versus 1.78±0.126, p <0.0001) between diabetics and control group. FBS (172.17±30.55 versus 137.06±37.76, p<0.0001), PPBS (243±61.21 versus 195.84±59.1, p = 0.0003) and HbA1C (8.42±1.292 versus 7.04±0.956, p<0.0001) were significantly higher in hypomagnesemic diabetics as compared to normomagnesemic diabetics. Significant proportion of hypomagnesemic diabetics were suffering from retinopathy as compared to normomagnesemic diabetics (47.06% versus 19.70%, p = 0.0042). Diabetic nephropathy, neuropathy, hypertension and IHD were also higher in hypomagnesemic diabetics as compared to normomagnesemic diabetics, but insignificant. Conclusions: Prevalence of hypomagnesemia in Type 2 diabetics was 34%. Diabetics with hypomagnesemia had poor glycemic control. Hypomagnesemia was significantly associated with diabetic retinopathy.

show abstract

Section: Discussionsupporting

confidence: 55%

Study of serum magnesium level in patients with type 2 diabetes mellitus and it’s correlation with glycosylated hemoglobin and diabetic complications

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Diabetiker von Magnesiummangel betroffen sind (Pham et al 2007, Sales et al 2011, Rashees et al 2012. Vermutet wird, dass der niedrige Magnesiumgehalt durch eine verminderte Magnesiumaufnahme oder erhöhte Verluste von Magnesium mit dem Urin zustande kommen (osmotische Diurese) (Barbagallo et al 2003, Ponder et al 1990).…”

unclassified

Oral supplementation of magnesium aspartate hydrochloride in horses with Equine Metabolic Syndrome

Winter¹,

Liertz²,

Merle³

et al. 2016

PHK

View full text Add to dashboard Cite

Diabetes mellitus type 2 is a worldwide problem in human medicine as is the equine equivalent "Equine Metabolic Syndrome" (EMS). In humans, an inverse relationship between serum magnesium content and the incidence of diabetes mellitus type II has been shown. Humans with peripheral insulin resistance often show cellular magnesium deficits and multiple studies have demonstrated the beneficial effect of dietary magnesium supplementation on insulin sensitivity. One study has evaluated the effects of magnesium supplementation on insulin sensitivity in laminitic horses and could not find differences. In this previous study, a different magnesium formulation (magnesium oxide) and dosage had been used. The purpose of this study was to evaluate the effects of an oral supplementation with magnesium aspartate hydrochloride in horses with Equine Metabolic Syndrome. The study was performed on five horses (four mares and one gelding) of different breeds, aged seven to 26 years with Equine Metabolic Syndrome based on the results of a CGIT (Combined Glucose Insulin Tolerance Test). In these horses body weight, Body Condition Score (BCS) and Cresty Neck Score (CNS) were assessed. The following blood parameters were measured in the serum: magnesium (Mg 2+ ), ACTH, fructosamine, reciprocal inverse square of insulin (RISQI) and modified insulin to glucose ratio (MIRG). Gamma-glutamyltransferase (GGT) and triglyzerides (TG) were measured in EDTA blood samples. All horses were supplemented with 30 mg/kg BW magnesium as magnesium aspartate hydrochloride for a time period of three month. Afterwards all blood parameters and the CGIT were repeated. A Wilcoxon signed rank test was used for non-normally distributed data. Statistical significance was set at 95 %. All horses had increased BCS and CNS ). The magnesium content in the serum, ACTH, GGT, TG and MIRG before supplementation were within the reference ranges in all horses. The fructosamine content was increased in horses one, four and five. RISQI was decreased in horse five. During the magnesium supplementation, no adverse effects were observed. There were no significant changes in body weight, BCS and CNS. There were also no significant changes regarding serum magnesium concentration, ACTH, RISQI and MIRG or GGT and TG. There was a tendency for decreased fructosamine concentration, which was also not statistically significant. In three of five horses the CGIT after magnesium supplementation was negative. These horses reached their glucose baseline levels after at least 45 minutes, while insulin (baseline and after 45 minutes) was within the reference ranges. The remaining two horses did not show significant differences compared to the beginning of the trial. It is concluded that the supplementation of magnesium aspartate hydrochloride in horses with Equine Metabolic Syndrome can have positive effects on the insulin sensitivity. Further examinations with more horses are necessary.

show abstract

“…A previous study in young diabetes subjects in Bangladeshis showed that more than half the subjects were hypomagnesemic (Khan et al, 1999). Furthermore, a recent cross sectional study showed lowered mean magnesium intake, urine magnesium, plasma magnesium, and erythrocyte magnesium in T2DM subjects with poor glucose control (Sales et al, 2011). However, because the lack of randomized interventional studies, the role of magnesium in hyperglycemia in T2DM subjects is not clear and future studies are required.…”

Section: Dietary Minerals and Blood Glucose Regulationmentioning

confidence: 92%

Impact of Diet Composition on Blood Glucose Regulation

Russell

Baka

Björck

et al. 2013

Critical Reviews in Food Science and Nutrition

152

107

View full text Add to dashboard Cite

Nutritional management of blood glucose levels is a strategic target in the prevention and management of type 2 diabetes mellitus (T2DM). To implement such an approach, it is essential to understand the effect of food on glycemic regulation and on the underlying metabolic derangements. This comprehensive review summarizes the results from human dietary interventions exploring the impact of dietary components on blood glucose levels. Included are the major macronutrients; carbohydrate, protein and fat, micronutrient vitamins and minerals, nonnutrient phytochemicals and additional foods including low-calorie sweeteners, vinegar, and alcohol. Based on the evidence presented in this review, it is clear that dietary components have significant and clinically relevant effects on blood glucose modulation. An integrated approach that includes reducing excess body weight, increased physical activity along with a dietary regime to regulate blood glucose levels will not only be advantages in T2DM management, but will benefit the health of the population and limit the increasing worldwide incidence of T2DM.

show abstract

Influence of magnesium status and magnesium intake on the blood glucose control in patients with type 2 diabetes

Cited by 70 publications

References 21 publications

Study of serum magnesium level in patients with type 2 diabetes mellitus and it’s correlation with glycosylated hemoglobin and diabetic complications

Study of serum magnesium level in patients with type 2 diabetes mellitus and it’s correlation with glycosylated hemoglobin and diabetic complications

Oral supplementation of magnesium aspartate hydrochloride in horses with Equine Metabolic Syndrome

Impact of Diet Composition on Blood Glucose Regulation

Contact Info

Product

Resources

About