Influence of luteolin on the apoptosis of esophageal cancer Eca109 cells and its mechanism of action

Wang, Shaokang; Fu, Lingmeng; Wu, Yi; Xiao, Hong‐Mei; Wang, Jing; Sun, Guiju

doi:10.1016/j.fshw.2019.03.014

Cited by 9 publications

(3 citation statements)

References 36 publications

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“…This initiates caspase-3 and other caspase cascade reactions resulting in apoptosis of the cell [ 33 ]. Similar effects were also observed in esophageal cancer Eca109 cell line and A172 and U-373MG, human glioblastoma cell lines [ 34 , 35 ]. The apoptosis of breast cancer cell line MDA-MB-231 was observed to be induced by downregulating human telomerase reverse transcriptase protein (hTERT).…”

Section: Mechanistic Insight Into the Anticancer Activity Of Luteolinsupporting

confidence: 70%

Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives

Tuli

Rath

Chauhan

et al. 2022

Cancers

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Increasing rates of cancer incidence and the toxicity concerns of existing chemotherapeutic agents have intensified the research to explore more alternative routes to combat tumor. Luteolin, a flavone found in numerous fruits, vegetables, and herbs, has exhibited a number of biological activities, such as anticancer and anti-inflammatory. Luteolin inhibits tumor growth by targeting cellular processes such as apoptosis, cell-cycle progression, angiogenesis and migration. Mechanistically, luteolin causes cell death by downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, Bcl-2, and Bcl-xL, while upregulating BAX, caspase-3, and p21. It has also been reported to inhibit STAT3 signaling by the suppression of STAT3 activation and enhanced STAT3 protein degradation in various cancer cells. Therefore, extensive studies on the anticancer properties of luteolin reveal its promising role in chemoprevention. The present review describes all the possible cellular interactions of luteolin in cancer, along with its synergistic mode of action and nanodelivery insight.

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Section: Mechanistic Insight Into the Anticancer Activity Of Luteolinsupporting

confidence: 70%

Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives

Tuli

Rath

Chauhan

et al. 2022

Cancers

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show abstract

“…erefore, it is very meaningful to research the change of helices domain structure which is closely associated with the activity of lysozyme. Flavonoids exhibit a wide range of physiological activity [7,8], which have specific nutritional and medicinal values with antioxidant, antiviral, and antibacterial activities, such as luteolin and its glycoside (luteoloside, luteolin-7-O-glucoside) (Figure 1) widely distributed in vegetables, fruits, and some food-medicine herbs including pepper, chrysanthemum indicum, honeysuckle, and perilla, approved by the National Ministry of Health. Although lysozyme, luteolin, or luteoloside has many biological activities with little drug resistance, the biological activity of them used alone is limited.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Luteolin and Luteoloside on the Secondary Structure of Lysozyme

Cui

et al. 2021

Journal of Food Quality

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The changes of lysozyme conformation in the absence and presence of luteolin and luteoloside were investigated by spectral analysis including fluorescence, UV, CD, Raman, and ATR-FTIR, and the biological activity of lysozyme was investigated by lysozyme assay kit. The results showed that the microenvironment hydrophobicity of lysozyme increased and peptide extension decreased with the addition of luteolin or luteoloside. The α-helix of lysozyme might be influenced by luteolin or luteoloside, and its relative content had a significant difference after adding luteolin or luteoloside by the ATR-FTIR method, which was reconfirmed by CD and Raman spectra. The lysozyme activity changed obviously after adding luteolin or luteoloside. All of the conclusions above indicated the active site of lysozyme in the α-helix might be influenced by luteolin and luteoloside.

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“…Luteolin (LUT) is a metabolite belonging to flavonoids, which exists widely in many plants and their by-products, and is one of the most bioactive flavonoids [ 7 ]. LUT has received much attention for its excellent anti-cancer and anti-inflammatory activities [ 8 , 9 ]. LUT could be used to treat various cancers, such as lung and breast cancers [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

Potential Application of Luteolin as an Active Antibacterial Composition in the Development of Hand Sanitizer Products

Hou

Wang

et al. 2022

Molecules

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Antibacterial hand sanitizers could play a prominent role in slowing down the spread and infection of hand bacterial pathogens; luteolin (LUT) is potentially useful as an antibacterial component. Therefore, this study elucidated the antibacterial mechanism of LUT against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) and developed an antibacterial hand sanitizer. The results showed that LUT had excellent antibacterial activity against both E. coli (minimum inhibitory concentration (MIC)= 312.5 μg/mL, minimal bactericidal concentration (MBC) = 625 μg/mL), and S. aureus (MIC = 312.5 μg/mL, MBC = 625 μg/mL). Furthermore, LUT induced cell dysfunction in E. coli and S. aureus, changed membrane permeability, and promoted the leakage of cellular contents. Confocal laser scanning microscopy (CLSM) and scanning electron microscopy (SEM) analysis showed that LUT treatment affected cell structure and disrupted cell membrane integrity. The Fourier transform infrared analysis (FTIR) also confirmed that the LUT acted on the cell membranes of both E. coli and S. aureus. Overall, the application of LUT in hand sanitizer had better inhibition effects. Therefore, this study could provide insight into expanding the application of LUT in the hand sanitizer markets.

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Influence of luteolin on the apoptosis of esophageal cancer Eca109 cells and its mechanism of action

Cited by 9 publications

References 36 publications

Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives

Luteolin, a Potent Anticancer Compound: From Chemistry to Cellular Interactions and Synergetic Perspectives

The Effect of Luteolin and Luteoloside on the Secondary Structure of Lysozyme

Potential Application of Luteolin as an Active Antibacterial Composition in the Development of Hand Sanitizer Products

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