Influence of <i>Lactobacillus pentosus</i> S-PT84 Ingestion on the Mucosal Immunity of Healthy and <i>Salmonella</i> Typhimurium-Infected Mice

Abstract

Lactobacillus pentosus (L. pentosus) strain S-PT84, isolated from Kyoto pickles, enhances splenic natural killer (NK) cell activity, and has high T-helper1 (Th1) cytokine and type 1-IFN (IFN-α) inducing activity. In the present study, we investigated the influence of S-PT84 ingestion on the mucosal immunity of healthy and Salmonella Typhimurium (S. Typhimurium)-infected mice. In the S. Typhimurium infection model, numbers of S. Typhimurium in feces and the spleen were significantly decreased, and body weight loss and deterioration in the general health score of S. Typhimurium-infected mice were improved by S-PT84 ingestion. Oral administration of S-PT84 enhanced IL-5 and IL-6 production from Peyer’s patch cells in vitro, with a concomitant significant increase in IgA production from Peyer’s patch cells, which may explain the mechanism of enhanced IgA production in the small intestine in vivo. These results suggest that S-PT84 ingestion is useful for the maintenance of health or the improvement of certain symptoms during pathogen infection.

Comparison of the Immunomodulatory Effects of Live and Heat-killed Lactobacillus pentosus S-PT84

“…[21][22][23] Heat-killed S-PT84 has also been shown to enhance immune function as well as preventing virus or pathogenic microorganism infection in mice. [18][19][20] In this study, we compared the immunomodulatory effects between live and heat-killed S-PT84. The results of the present study showed that heat-killed S-PT84 was more effective in inducing IL-12 or IFN-γ production than live S-PT84 in vitro.…”

“…Heat-killed S-PT84 can stimulate IL-12 and IFN-γ production C 2011 The Pharmaceutical Society of Japan through interactions between dendritic cells and natural killer (NK) cells, 16) and can induce several beneficial immunomodulatory effects including the inhibition of allergic reaction and the prevention of virus or pathogenic microorganism infection in mice. [17][18][19][20] However, it was not known whether live S-PT84 exhibits additive effects compared to heat-killed S-PT84. Therefore, we compared the immunomodulatory effects between live and heatkilled S-PT84 in BALB/c mice.…”

Sulforaphane enhances apoptosis induced by Lactobacillus pentosus strain S‑PT84 via the TNFα pathway in human colon cancer cells

“…Izumo et al (28,29) and Hayama et al (30) reported that the Lactobacillus (L.) pentosus strain S-PT84, isolated from Kyoto pickles, has inhibitory activity against influenza virus, Salmonella Typhimurium, and Candida albicans infection in mice, and S-PT84 enhances IFN-α production from plasmacytoid dendritic cells by virus stimulation (31).…”

Biological potency and characterization of antibacterial substances produced by Lactobacillus pentosus isolated from Hentak, a fermented fish product of North-East India

“…Lactobacillus pentosus is a lactic acid bacterium commonly used as starter culture for the fermentation process (Ruiz-Barba et al 1994). Certain strains of L. pentosus exert probiotic properties, improve mucosal immunity and create resistance towards bacterial infections (Kotani et al 2010; Izumo et al 2011). …”