Influence of &lt;em&gt;MDM2&lt;/em&gt; polymorphisms on squamous cell carcinoma susceptibility: a meta-analysis

Yu, Huanxin; Li, Haiyan; Zhang, Jinling; Liu, Gang

doi:10.2147/ott.s113417

Cited by 8 publications

(12 citation statements)

References 48 publications

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“…The results of prediction intervals are wide, suggesting that future research may demonstrate benefit, disadvantage, or not demonstrate any statistically significant difference. [25] Similar to our analysis, some meta-analysis demonstrated that MDM2 rs2279744 is associated with squamous cell carcinoma, [26] colorectal cancer, [27] endometrial cancer, [28] and hepatocellular carcinoma. [29] But 2 meta-analyses indicated that MDM2 rs2279744 polymorphism cannot be considered as genetic risk factors for osteosarcoma, [30] and prostate cancer.…”

Section: Discussionsupporting

confidence: 83%

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility

Cao

Wang

Song³

et al. 2018

Medicine

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Retinoblastoma (Rb) is the most common intra-ocular malignancy in children. The association of rs2279744, and rs937283 in MDM2 gene, and p21 rs1801270 polymorphism and RB development have been demonstrated. To provide a comprehensive assessment of and to clarify associations between the 3 SNPs (MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270) and the risk of RB, we performed a meta-analysis of all the eligible case-control studies. We searched English databases include PubMed, Embase, Google Scholar, and Cochrane Library, using an upper date limit of January 1, 2018. The association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and the risk of RB were estimated by calculating a pooled OR and 95% CI under a homozygote comparison, heterozygote comparison, dominant model, and recessive model. The statistical power analysis was performed using G∗Power. Our meta-analysis showed a significant association between RB susceptibility and MDM2 rs2279744 recessive model (OR = 1.427, 95%CI: 1.107-1.840, P = .006, I2 = 0%). Moreover, a significant link was observed between RB risk and MDM2 rs937283 homozygote comparison (OR = 0.471, 95%CI: 0.259-0.858, P = .014, I2 = 0%) and recessive model (OR = 0.587, 95%CI: 0.410-0.840, P = .004, I2 = 0%). However, no significant relationship between the p21 rs1801270 polymorphism and RB susceptibility was detected in any of the 4 models (P > .05). In conclusion, we found that significant association between the MDM2 rs2279744 polymorphism and increased RB risk, while MDM2 rs937283 polymorphism was associated with significantly decreased RB risk. However, as to the P21 rs1801270 polymorphism, a statistically significant association was not identified for RB.

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Section: Discussionsupporting

confidence: 83%

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility

Cao

Wang

Song³

et al. 2018

Medicine

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“…After careful examination and assessment, three publications were excluded for the following reasons: one had duplicate data with the previous research 20 and other two were irrelevant with cancer risk. 21 , 22 All studies were in agreement with HWE, except for an article by Jin et al 11 We included this article for the further study because genotype distribution of the TP53 Arg72 Pro polymorphism was in accordance with HWE in the same study. 11 Of these 11 publications, two publications involved two cancer types 14 , 23 and one publication involved four cancer types.…”

Section: Resultsmentioning

confidence: 99%

“…A latest meta-analysis conducted by Yu et al found that there was no significant difference between del1518 polymorphism and overall squamous cell carcinoma susceptibility with a total of 309 cases and 1,000 controls from three studies, results of which is consistent with the current study. 22 …”

Section: Discussionmentioning

confidence: 99%

<em>MDM2</em> promoter del1518 polymorphism and cancer risk: evidence from 22,931 subjects

Hua

Zhang

Duan

et al. 2017

OTT

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Studies have shown that single-nucleotide polymorphisms in MDM2 gene may play important roles in the development of malignant tumor. The association of del1518 polymorphism (rs3730485) in the MDM2 promoter with cancer susceptibility has been extensively studied; however, the results are contradictory. To quantify the association between this polymorphism and overall cancer risk, we conducted a meta-analysis with 12,905 cases and 10,026 controls from 16 eligible studies retrieved from PubMed, Embase, and Chinese Biomedical (CBM) databases. We assessed the strength of the connection using odds ratios (ORs) and 95% confidence intervals (CIs). In summary, no significant associations were discovered between the del1518 polymorphism and overall cancer risk (Del/Del vs Ins/Ins: OR =1.01, 95% CI =0.90–1.14; Ins/Del vs Ins/Ins: OR =1.03, 95% CI =0.96–1.12; recessive model: OR =0.98, 95% CI =0.90–1.07; dominant model: OR =1.03, 95% CI =0.94–1.12; and Del vs Ins: OR =1.01, 95% CI =0.94–1.07). In the stratified analysis by source of control, quality score, cancer type, and ethnicity, no significant associations were found. Despite some limitations, the current meta-analysis provides solid statistical evidence of lacking association between the MDM2 del1518 polymorphism and cancer risk.

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“…Squamous cell carcinoma (SCC) is the most common histological type of several clinical cancers, such as head and neck cancer, esophageal cancer, skin cancer, lung cancer, and cervical cancer [ 8 , 9 ]. The exact pathogenesis of SCC remains unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Living habits (e.g., smoking, drinking), viral infection [e.g., human papillomavirus (HPV)], immune system, and polymorphic variants with many genes may be related to the risk of different SCC diseases [ 10 – 12 ]. Previously, we conducted an updated meta-analysis to explore the impact of MDM2 (MDM2 Proto-Oncogene) polymorphisms on SCC susceptibility and found that the GG genotype of MDM2 rs2279744 polymorphism may be associated with an increased risk of esophageal SCC in Asian populations [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of the role of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 gene in the risk of squamous cell carcinoma

Hai

2018

Cancer Cell Int

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BackgroundTo explore the genetic effect of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 (CYP2E1) gene on the risk of squamous cell carcinoma (SCC), a meta-analysis was performed.MethodsThe eligible case–control studies were obtained by database searching and screening, and the specific statistical analysis was performed with STATA 12.0 software.ResultsAfter the process of database searching and screening, a total of 32 case–control studies with 7435 cases and 10,466 controls were ultimately included in our meta-analysis. With regard to the rs2031920 C/T polymorphism, in comparison to controls, a reduced risk in cases of esophageal squamous cell carcinoma (ESCC) was detected for the models of allele T vs. allele C [P = 0.025, odds ratio (OR) = 0.67], carrier T vs. carrier C (P = 0.014, OR = 0.70), TT vs. CC (P = 0.029, OR = 0.65), CT vs. CC (P = 0.040, OR = 0.56), CT + TT vs. CC (P = 0.035, OR = 0.58). Similarly, a decreased SCC risk was observed for the rs3813867 G/C polymorphism in the allele, carrier, homozygote, dominant, and recessive models of overall SCC meta-analysis and “ESCC” subgroup analysis (all P < 0.05, OR < 1) and in all genetic models of “Asian” and “population-based control (PB)” subgroup analysis (all P < 0.05, OR < 1). Additionally, for the rs2031920/rs3813867 haplotype, a decreased SCC risk was also detected in the overall SCC meta-analysis under the allele, carrier, homozygote and dominant model (all P < 0.05, OR < 1) and the subgroup analysis of “PB” under the allele, carrier, and dominant models (all P < 0.05, OR < 1).ConclusionsOur meta-analysis supports the “T” allele carrier of the CYP2E1 rs2031920 C/T polymorphism and “C” allele carrier of the rs3813867 G/C polymorphism as protective factors for ESCC patients, especially in Asian populations.

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Influence of <em>MDM2</em> polymorphisms on squamous cell carcinoma susceptibility: a meta-analysis

Cited by 8 publications

References 48 publications

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility

Association between MDM2 rs2279744, MDM2 rs937283, and p21 rs1801270 polymorphisms and retinoblastoma susceptibility

<em>MDM2</em> promoter del1518 polymorphism and cancer risk: evidence from 22,931 subjects

Analysis of the role of rs2031920 and rs3813867 polymorphisms within the cytochrome P450 2E1 gene in the risk of squamous cell carcinoma

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