Influence of low tryptophan diet on survival and organ growth in mice

Marte, M.; Enesco, Hildegard E.

doi:10.1016/0047-6374(86)90017-5

Cited by 83 publications

(53 citation statements)

References 14 publications

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“…Thus, other amino acids have a role in lifespan regulation. In agreement with this concept, restriction of tryptophan increases mouse lifespan [9]. Dietary amino acid composition affects lifespan by regulating various nutrient-sensing signaling pathways.…”

Section: Role Of Specific Amino Acids In Longevitysupporting

confidence: 48%

Amino Acids: Sensing and Implication into Aging

Lushchak

2015

jpnu

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Abstract. An ability to sense and respond to nutrient availability is an important requisite for life. Nutrient limitation is among main factors to influence the evolution of most cellular processes. Different pathways that sense intracellular and extracellular levels of carbohydtrates, amino acids, lipids, and intermediate metabolites are integrated and coordinated at the organismal level through neuronal and humoral signals. During food abundance, nutrient-sensing pathways engage anabolism and storage, whereas limitation triggers the mechanisms, such as the mobilization of internal stores including through autophagy. These processes are affected during aging and are themselves important regulators of longevity, stress resistance, and age-related complications.

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Section: Role Of Specific Amino Acids In Longevitysupporting

confidence: 48%

Amino Acids: Sensing and Implication into Aging

Lushchak

2015

jpnu

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“…Methionine restriction extends the lifespan of rats by up to 42% (Orentreich et al, 1993;Richie et al, 1994;Miller et al, 2005). Restriction of dietary tryptophan also extends the lifespan of rats and mice (Segall & Timiras, 1976;De Marte & Enesco, 1986;Ooka et al, 1988). However, interpretation of these results is problematic due to the small sample sizes, high early-life mortality, and modest lifespan effects.…”

Section: Other Gene-expression Biomarkers Of Longevitymentioning

confidence: 93%

Use of microarray biomarkers to identify longevity therapeutics

Spindler

2006

Aging Cell

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SummaryA number of lines of evidence, including nonhuman primate and human studies, suggest that regulatory pathways similar to those invoked by caloric restriction (CR) may be involved in determining human longevity. Thus, pharmaceuticals capable of mimicking the molecular mechanisms of life-and health-span extension by CR (CR mimetics) may have application to human health. CR acts rapidly, even in late adulthood, to begin to extend life-and health-span in mice. We have linked these effects with rapid changes in the levels of specific gene transcripts in the liver and the heart. Our results are consistent with the rapid effects of caloric intake on the lifespan and/or biochemistry and physiology of Drosophila , rodents, rhesus macaques and humans. To test the hypothesis that existing pharmaceuticals can mimic the physiologic effects of CR, we evaluated the effectiveness of glucoregulatory drugs and putative cancer chemopreventatives in reproducing the hepatic gene-expression profiles produced by long-term CR (LTCR). We found that 8 weeks of metformin treatment was superior to 8 weeks of CR at reproducing the specific changes in transcript levels produced by LTCR. Consistent with these results, metformin reduces cancer incidence in diabetic humans and ameliorates the onset and severity of metabolic syndrome. Metformin extends the mean and maximum lifespans of female transgenic HER-2/neu mice by 8% and 13.1% in comparison with control mice. Phenformin, a close chemical relative of metformin, extends lifespan and reduces tumor incidence in C3H mice. These results indicate that gene-expression biomarkers can be used to identify promising candidate CR mimetics.

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“…It should be noted, however, that one rat study found increased mortality during the juvenile period and consequently an overall decrease in mean life span (112). This negative effect on early mortality was not observed in mice on a tryptophan-depleted diet, and the mice showed an increase in mean and maximum life span and no differences in food intake (113). Thus, tryptophan's effects on juvenile survival need further study.…”

Section: Dietary Restriction Alternatives To Crmentioning

confidence: 99%

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

Minor

Allard

Younts

et al. 2010

The Journals of Gerontology Series A: Biological Sciences and M

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The societal impact of obesity, diabetes, and other metabolic disorders continues to rise despite increasing evidence of their negative long-term consequences on health span, longevity, and aging. Unfortunately, dietary management and exercise frequently fail as remedies, underscoring the need for the development of alternative interventions to successfully treat metabolic disorders and enhance life span and health span. Using calorie restriction (CR)-which is well known to improve both health and longevity in controlled studies-as their benchmark, gerontologists are coming closer to identifying dietary and pharmacological therapies that may be applicable to aging humans. This review covers some of the more promising interventions targeted to affect pathways implicated in the aging process as well as variations on classical CR that may be better suited to human adaptation.

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Influence of low tryptophan diet on survival and organ growth in mice

Cited by 83 publications

References 14 publications

Amino Acids: Sensing and Implication into Aging

Amino Acids: Sensing and Implication into Aging

Use of microarray biomarkers to identify longevity therapeutics

Dietary Interventions to Extend Life Span and Health Span Based on Calorie Restriction

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