Influence of low temperature ageing on optical and mechanical properties of transparent yittria stabilized-zirconia cranial prosthesis

Davoodzadeh, Nami; Uahengo, Gottlieb; Halaney, David L.; Garay, Javier E.; Aguilar, Guillermo

doi:10.1117/12.2287296

Cited by 2 publications

(4 citation statements)

References 16 publications

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“…We have shown our 3YSZ, 6YSZ, and 8YSZ samples with AGS of 147 nm ± 45 nm, prepared using CAPAD, satisfy the requirements for long‐term performance as an optical implant. Indeed, for all the investigated samples the increase in monoclinic phase content was below the XRD and micro‐Raman detection range, in agreement with our previous findings (Aguilar et al, ). The ageing tests showed the ability of these materials to withstand common sterilization treatments as well.…”

Section: Discussionsupporting

confidence: 92%

“…Previously, we have investigated the application of 8YSZ for creating transparent cranial implants. By performing biocompatibility tests and brain imaging studies, we have demonstrated the feasibility of this application (Aguilar, Davoodzadeh, Halaney, Uahengo, & Garay, ; Aminfar et al, ; Cano‐Velázquez et al, ; Damestani et al, ; Damestani, Galan‐Hoffman, Ortiz, Cabrales, & Aguilar, ; Davoodzadeh, ; Davoodzadeh et al, ; Davoodzadeh, Cano‐Velázquez, et al, ; Davoodzadeh, Cuando, et al, ; Gutierrez et al, ; Halaney et al, ). Phase transformation (ageing) resistance and the effect of hydrothermal treatment on optical and mechanical properties of the ceramics are crucial to understand for any medical or nonmedical application of the transparent nc‐YSZ ceramics.…”

Section: Discussionmentioning

confidence: 97%

“…Phase transformation (ageing) resistance and the effect of hydrothermal treatment on optical and mechanical properties of the ceramics are crucial to understand for any medical or nonmedical application of the transparent nc‐YSZ ceramics. Recently, fabrication of translucent and transparent YSZ with grain size on the microscale and nanoscale have been reported (Aguilar et al, ; Casolco et al, ; Xiong, Fu, Pouchly, Maca, & Shen, ; Zhang et al, ). However, a thorough investigation on preparation and evaluation of LTD and its influence on mechanical and optical properties in transparent nanocrystalline stabilized zirconia ceramics with various yttria dopant levels of 3, 6, and 8 mol % have not been reported.…”

Section: Discussionmentioning

confidence: 99%

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Characterization of ageing resistant transparent nanocrystalline yttria‐stabilized zirconia implants

et al. 2019

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The “Window to the Brain” is a transparent cranial implant under development, based on nanocrystalline yttria‐stabilized zirconia (nc‐YSZ) transparent ceramic material. Previous work has demonstrated the feasibility of this material to facilitate brain imaging over time, but the long‐term stability of the material over decades in the body is unknown. In this study, the low‐temperature degradation (LTD) of nc‐YSZ of 3, 6, and 8 mol % yttria is compared before and after accelerated ageing treatments following ISO standards for assessing the ageing resistance of zirconia ceramics. After 100 hr of accelerated ageing (equivalent to many decades of ageing in the body), the samples do not show any signs of phase transformation to monoclinic by X‐ray diffraction and micro‐Raman spectroscopy. Moreover, the mechanical hardness of the samples did not decrease, and changes in optical transmittance from 500 to 1000 nm due to ageing treatments was minimal (below 3% for all samples), and unlikely to be due to phase transformation of surface crystals to monoclinic. These results indicate the nc‐YSZ has excellent ageing resistance and can withstand long‐term implantation conditions without exhibiting LTD.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Characterization of ageing resistant transparent nanocrystalline yttria‐stabilized zirconia implants

et al. 2019

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“…Conventional cranial prosthesis including titanium, alumina, and acrylic have not provided the requisite combination of transparency and toughness required for clinically‐viable transparent cranial implants. To address this challenge, our group has previously introduced a transparent nanocrystalline yttria‐stabilized‐zirconia cranial implant material, which possesses the mechanical strength and biocompatibility that are prerequisites for a clinically‐viable permanent cranial implant for patients . We refer to this in the literature as the “Window to the Brain” (WttB) implant.…”

Section: Introductionmentioning

confidence: 99%

Optical Access to Arteriovenous Cerebral Microcirculation Through a Transparent Cranial Implant

et al. 2019

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Background and Objective Microcirculation plays a critical role in physiologic processes and several disease states. Laser speckle imaging (LSI) is a full‐field, real‐time imaging technique capable of mapping microvessel networks and providing relative flow velocity within the vessels. In this study, we demonstrate that LSI combine with multispectral reflectance imaging (MSRI), which allows for distinction between veins and arteries in the vascular flow maps produced by LSI. We apply this combined technique to mouse cerebral vascular network in vivo, comparing imaging through the skull, to the dura mater and brain directly through a craniectomy, and through a transparent cranial “Window to the Brain” (WttB) implant. Study Design/Materials and Methods The WttB implant used in this study is made of a nanocrystalline Yttria‐Stabilized‐Zirconia ceramic. MSRI was conducted using white‐light illumination and filtering the reflected light for 560, 570, 580, 590, 600, and 610 nm. LSI was conducted using an 810 nm continuous wave near‐infrared laser with incident power of 100 mW, and the reflected speckle pattern was captured by a complementary metal‐oxide‐semiconductor (CMOS) camera. Results Seven vessel branches were analyzed and comparison was made between imaging through the skull, craniectomy, and WttB implant. Through the skull, MSRI did not detect any vessels, and LSI could not image microvessels. Imaging through the WttB implant, MSRI was able to identify veins versus arteries, and LSI was able to image microvessels with only slightly higher signal‐to‐noise ratio and lower sharpness than imaging the brain through a craniectomy. Conclusions This study demonstrates the ability to perform MSRI‐LSI across a transparent cranial implant, to allow for cerebral vascular networks to be mapped, including microvessels. These images contain additional information such as vein‐artery separation and relative blood flow velocities, information which is of value scientifically and medically. The WttB implant provides substantial improvements over imaging through the murine cranial bone, where microvessels are not visible and MSRI cannot be performed. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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Influence of low temperature ageing on optical and mechanical properties of transparent yittria stabilized-zirconia cranial prosthesis

Cited by 2 publications

References 16 publications

Characterization of ageing resistant transparent nanocrystalline yttria‐stabilized zirconia implants

Characterization of ageing resistant transparent nanocrystalline yttria‐stabilized zirconia implants

Optical Access to Arteriovenous Cerebral Microcirculation Through a Transparent Cranial Implant

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