Influence of Low Protein Diet Supplemented with Amino Acids and Keto Acids on the Progression of Chronic Renal Failure

Does a Low Protein Diet Really Slow Down the Rate of Progression of Chronic Renal Failure?

“…Thus, also in the papers of Rosman et al [19] and Schmicker et al [20] the most im portant modification in the course of the underlying renal disease is found in patients suffering from glomerulonephritis. This fa vorable response of patients having glomeru lonephritis to dietary treatment might have two reasons: glomerular hyperfiltration might be reduced and there might be a direct in fluence of protein restriction on immunolog ical phenomena active in this type of renal disease.…”

“…These authors found a comparable factor in pa tients suffering from glomerulonephritis. In the paper of Schmicker et al [20], patients having glomerulonephritis exhibited the highest factor of delay (2.0), followed by pa tients suffering from pyelonephritis/interstitial nephritis (1.6), and patients with poly cystic kidney disease ( 1.4).…”

“…These findings are in good agreement with the data of Rosman et al [ 19], who found a factor of delay of 2.8 in their patients suffering from glomerulone phritis (table II). Schmicker et al [20] found a factor of delay of 2.0, when comparing the median time to pass the serum creatinine interval (6-10 mg/dl) of patients on a 0.6-g protein-restricted diet versus that of patients of a 0.4-g protein-restricted diet, supple mented with amino and keto acids. This lower factor is not unexpected, as their pa tients of the control group were already on a low protein diet.…”

Relationship between Proteinuria and Response to Low Protein Diets Early in Chronic Renal Failure

“…Several retrospective and prospective studies confirmed their benefi cial effect on the progression of chronic renal failure [1][2][3][4][5]. If applied early in renal dis ease, they can postpone or even prevent the need for dialysis.…”

What Can Be Safely Said about Predialysis Treatment?

“…Through 20 years' experience we have achieved very good compliance under sev eral kinds of treatment [2,3]. An important point in this field is to allow each patient the In mild renal insufficiency it is necessary only to prevent excesses of protein intake and to reduce the intake of phosphorus to about 900 mg/day.…”