Influence of Low-Intensity Pulsed Ultrasound Parameters on the Bone Mineral Density in Rat Model: A Systematic Review

Pereira, Luiz Fernando; Fontes-Pereira, Aldo José; Pereira, Wagner Coelho de Albuquerque

doi:10.1016/j.ultrasmedbio.2023.03.001

Cited by 2 publications

(3 citation statements)

References 61 publications

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“…Accumulating evidence suggests that ion fluxes through Na + , K + , Cl – , and Ca 2+ channels are activated after electric signals, which subsequently regulate cell functions, while the Ca 2+ influx plays a significant role in the osteogenic differentiation of MSCs. , In this study, the piezoelectric effect triggered by BCG-NPs under US distinctly increased intracellular Ca 2+ concentrations (Figure A). Moreover, downregulated ALP activity and RUNX2 expression levels were detected (Figures C–F) when HWJ-MSCs were treated with intracellular calcium chelator BAPTA-AM.…”

Section: Discussionmentioning

confidence: 48%

A Biomimetic Nanogenerator to Enhance Bone Regeneration by Restoring Electric Microenvironments

Chen,

Xie

et al. 2023

ACS Biomater. Sci. Eng.

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Piezoelectric materials have received increasing attention in bone regeneration due to their prominent role in bioelectricity in bone homeostasis. This study aimed to develop bioactive barium titanate− chitosan−graphene oxide piezoelectric nanoparticles (BCG-NPs) to improve biocompatibility and stimulate bone repair. Butterfly loops, hysteresis loops, and in vitro microcurrent studies on BCG-NPs confirmed their good piezoelectric properties. BCG-NPs exhibited enhanced alkaline phosphatase activity, mineralized nodule formation, and expression of osteogenic-associated proteins and genes in human umbilical cord Wharton's jelly-derived mesenchymal stem cells by creating microelectric environments in response to noninvasive ultrasound stimulation. Further, BCG-NPs upregulated intracellular calcium ions via electrical stimulation. They acted synergistically with piezo-type mechanosensitive ion channel component 1 and calcium-permeable cation channel transient receptor potential vanilloid 4 to activate osteogenic differentiation. In conclusion, ultrasound-assisted BCG-NPs created a microelectric environment that putatively promoted bone repair in a noninvasive manner.

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Section: Discussionmentioning

confidence: 48%

A Biomimetic Nanogenerator to Enhance Bone Regeneration by Restoring Electric Microenvironments

Chen,

Xie

et al. 2023

ACS Biomater. Sci. Eng.

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“…Generally, 2 of 26 LIPUS is a specific type of ultrasound with a frequency of 0.045-3 MHz and intensity of 0.02-l W/cm 2 [13][14][15][16][17]. The widely used parameters are 1.5 MHz frequency, 30 mW/cm 2 intensity, 200 µs pulse duration, and 20 min/d exposure time [15,18]. LIPUS has been proven to promote cellular viability, proliferation, differentiation, and migration [13,19,20].…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, LIPUS has shown favorable outcomes in promoting bone fracture healing by inducing molecular, biological, and biomechanical alterations in the fracture vicinity. In addition, LIPUS has been scientifically validated to accelerate bone regeneration in cases of fresh fractures, delayed unions, non-unions, distraction osteogenesis, and musculoskeletal soft tissue injuries [17,18,[21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Musculoskeletal Biomaterials: Stimulated and Synergized with Low Intensity Pulsed Ultrasound

Jia,

Zhou,

Zhan

2023

JFB

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Clinical biophysical stimulating strategies, which have significant effects on improving the function of organs or treating diseases by causing the salutary response of body, have shown many advantages, such as non-invasiveness, few side effects, and controllable treatment process. As a critical technique for stimulation, the low intensity pulsed ultrasound (LIPUS) has been explored in regulating osteogenesis, which has presented great promise in bone repair by delivering a combined effect with biomaterials. This review summarizes the musculoskeletal biomaterials that can be synergized with LIPUS for enhanced biomedical application, including bone regeneration, spinal fusion, osteonecrosis/osteolysis, cartilage repair, and nerve regeneration. Different types of biomaterials are categorized for summary and evaluation. In each subtype, the verified biological mechanisms are listed in a table or graphs to prove how LIPUS was effective in improving musculoskeletal tissue regeneration. Meanwhile, the acoustic excitation parameters of LIPUS that were promising to be effective for further musculoskeletal tissue engineering are discussed, as well as their limitations and some perspectives for future research. Overall, coupled with biomimetic scaffolds and platforms, LIPUS may be a powerful therapeutic approach to accelerate musculoskeletal tissue repair and even in other regenerative medicine applications.

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Influence of Low-Intensity Pulsed Ultrasound Parameters on the Bone Mineral Density in Rat Model: A Systematic Review

Cited by 2 publications

References 61 publications

A Biomimetic Nanogenerator to Enhance Bone Regeneration by Restoring Electric Microenvironments

A Biomimetic Nanogenerator to Enhance Bone Regeneration by Restoring Electric Microenvironments

Musculoskeletal Biomaterials: Stimulated and Synergized with Low Intensity Pulsed Ultrasound

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