Influence of low-frequency vibration on changes of biochemical parameters of living rats

Kasprzak, C.; Damijan, Z.; Panuszka, Ryszard

doi:10.1121/1.4782140

Cited by 1 publication

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“…1 Rats repeatedly exposed to low-frequency vibration at 20 Hz exhibit altered LDL-and HDL-cholesterol levels. 18 Furthermore, several studies demonstrate the physiologic effects of noise on rodents, including increased norepinephrine and cholesterol levels in rats and decreased splenic lymphocyte counts in mice. 32 Whether similar changes occur in mice exposed to vibration is unknown.…”

Section: Discussionmentioning

confidence: 99%

Vibration-induced Behavioral Responses and Response Threshold in Female C57BL/6 Mice

Garner

Norton

Kinard³

et al. 2018

j am assoc lab anim sci

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Despite documented adverse effects, limits for rodent exposure to vibration in the laboratory animal facility have not been established. This study used female C57BL/6 mice to determine the frequencies of vibration at which mice were most sensitive to behavioral changes, the highest magnitude of vibration that would not cause behavioral changes, the behavioral changes that occur in response to vibration, and the extent to which mice habituate to vibration. Mice were exposed to frequencies of vibration between 20 and 190 Hz at accelerations of 0.05 to 1.0 m/s2. Behavioral responses were videorecorded and subsequently scored. Mice showed the most behavioral responses at 1.0 m/s2. At intermediate accelerations of 0.5 and 0.75 m/s2, behavioral responses were most prevalent at frequencies of 70 to 100 Hz. In contrast, at an acceleration of 0.05 m/s2, mice did not show any discernible behavioral response. Behavioral responses induced by the initiation of vibration were transient, generally lasting only 2 to 10 s. Behaviors in awake mice included abrupt freezing of motion, hunched posture, and surveying the cage environment. In mice that were asleep, responses consisted of lifting the head suddenly with or without prior shifting of body position. When exposed to multiple periods of vibration over a short time, responses seemed to decrease. In summary, mice were particularly sensitive to vibration between 70 to 100 Hz, did not respond to the slowest acceleration (0.05 m/s2), and exhibited transient responses at the initiation of vibration.

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Section: Discussionmentioning

confidence: 99%