Influence of Local Anesthetics on the Neuromuscular Blockade Produced by Rocuronium. Effects of Lidocaine and 50% Enantiomeric Excess Bupivacaine on the Neuromuscular Junction

Braga, Angélica de Fátima de Assunção; Carvalho, Vanessa Henriques; Braga, Franklin Sarmento da Silva; Rodrigues‐Simioni, Léa; Loyola, Yolanda Christina S.; Potério, Glória Braga

doi:10.1016/s0034-7094(09)70097-2

Cited by 15 publications

(16 citation statements)

References 25 publications

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“…In electrophysiological studies, similarly to other studies [4][5]22 , we observed that local anesthetics did not produce . The study of MEPPs is important to investigate the presynaptic effects of the drugs used, due to its interference in mediator release 22 .…”

Section: Discussionsupporting

confidence: 90%

“…The study of MEPPs is important to investigate the presynaptic effects of the drugs used, due to its interference in mediator release 22 . In contrast to previous reports on lidocaine [4][5]21 , describing that it initially increases MEPP frequency, the local anesthetics used in the study caused a progressive decrease both in the frequency and amplitude of these potentials until complete blockade.…”

Section: Discussioncontrasting

confidence: 68%

“…3 studied the effects of lidocaine and racemic bupivacaine on the presynaptic and postsynaptic components of synaptic transmission of the rat sympathetic ganglion and observed blockade in various stages of synaptic transmission. The effects of these drugs on membrane potentials and miniature end plate potentials were studied in rats and interference at some phase of neuromuscular transmission was described [4][5] .…”

Section: Introductionmentioning

confidence: 99%

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Evidence of presynaptic and postsynaptic action of local anesthetics in rats

et al. 2013

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PURPOSE:To assess the probable actions of ropivacaine, 50% enantiomeric excess bupivacaine mixture (S75-R25) and levobupivacaine on neuromuscular transmission in vitro. METHODS:Thirty rats were distributed into groups (n=5) according to the drug used: ropivacaine, bupivacaine (S75-R25) and levobupivacaine. The concentration used for the three local anesthetics (LA) was 5 µg.mL.-1 The following parameters were evaluated:1) LA effects on membrane potential (MP) and miniature end plate potential (MEPP). A chick biventer cervicis preparation was also used to evaluate LA effects on the contracture response to acetylcholine. RESULTS:LA did not alter MP values and decreased the frequency and amplitude of MEPP. In a chick biventer cervicis preparation, bupivacaine (S75-R25) and levobupivacaine decreased the contracture response to acetylcholine with statistical significance, in comparison to ropivacaine. CONCLUSIONS:In the concentrations used, levobupivacaine and bupivacaine (S75-R25) exhibited presynaptic and postsynaptic actions evidenced by alterations in miniature end plate potentials and contracture response to acetylcholine. Ropivacaine only had a presynaptic action.

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Section: Discussionsupporting

confidence: 90%

Section: Discussioncontrasting

confidence: 68%

Section: Introductionmentioning

confidence: 99%

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Evidence of presynaptic and postsynaptic action of local anesthetics in rats

et al. 2013

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“…neuromuscular blockers more indicated for rapid sequence intubation are succinylcholine and rocuronium due to their lower latency 26 . the interaction between local anesthetics and neuromuscular blockers is known and demonstrated in different models 19,23,24,39,40 . local anesthetics have a strong capability of inhibiting several subtypes of nicotinic receptors of acetylcholine, including muscular 22,[41][42][43] .…”

Section: Discussionmentioning

confidence: 99%

“…the interaction of local anesthetics with preand post-synaptic nicotinic receptors in the neuromuscular junction explains this phenomenon [22][23][24] .…”

Section: Introductionmentioning

confidence: 99%

Efeito da utilização de 2 mg.kg-1 de lidocaína endovenosa na latência de duas doses diferentes de rocurônio e na resposta hemodinâmica à intubação traqueal

Vivancos¹,

Klamt²,

Garcia³

2011

Rev. Bras. Anestesiol.

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Summary: Vivancos GG, Klamt JG, Garcia lV -effects of 2 mg.kg -1 of intravenous lidocaine on the latency of two Different Doses of Rocuronium and on the Hemodynamic Response of Orotracheal intubation.Background and objectives: lidocaine potentiates the effects of neuromuscular blockers and attenuates the hemodynamic response to orotracheal intubation. the objective of the present study was to test the effects of lidocaine on the latency of two different doses of rocuronium and on the hemodynamic response to intubation.

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The use of train of four monitoring for clinical evaluation of the axillary brachial plexus block

Şen

Sarı

Kurt

et al. 2013

J Clin Monit Comput

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The axillary approach of brachial plexus anesthesia is the most commonly used technique for forearm and hand surgery. Dynamometer is known as objective test for the clinical assessment of motor block of the nerves in brachial plexus block. However, the use of this device may not always be practical in operating room. The train-of-four (TOF) test is a non-invasive peripheral nerve stimulator that shows the level of motor block of muscle relaxants. The aim of the study is to investigate the use of TOF testing as a peripheral nerve stimulator for objective clinical evaluation of motor block at axillary brachial plexus block. 44 patients were randomized according to the development of partial or complete motor in the axillary brachial plexus block. The nerves were selectively localized by nerve stimulation and ultrasound guidance. After obtaining an appropriate peripheral motor response, predetermined volumes of bupivacaine were selectively injected to the 4 nerves. Sensory, motor block levels and TOF values were measured at 10th, 20th, 30th minutes immediately after the axillary brachial plexus block. TOF values were gradually decreased and significant difference was observed between the development of a complete and partial motor block at 30th minute. TOF values were also significantly less in patients of complete sensory block than the patients of partial sensory block at 30th minute. The use of TOF monitoring may be beneficial to assess the objective clinical effect of motor block in the patients with axillary brachial plexus nerve block.

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Influence of Local Anesthetics on the Neuromuscular Blockade Produced by Rocuronium. Effects of Lidocaine and 50% Enantiomeric Excess Bupivacaine on the Neuromuscular Junction

Abstract: Local anesthetics caused a potentiation of the neuromuscular blockade produced by rocuronium. The results showed pre- and post-synaptic effects.

Cited by 15 publications

References 25 publications

Evidence of presynaptic and postsynaptic action of local anesthetics in rats

Evidence of presynaptic and postsynaptic action of local anesthetics in rats

Efeito da utilização de 2 mg.kg-1 de lidocaína endovenosa na latência de duas doses diferentes de rocurônio e na resposta hemodinâmica à intubação traqueal

The use of train of four monitoring for clinical evaluation of the axillary brachial plexus block

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