Influence of Lithium Carbonate on Patients with Temporal Epilepsy

A, Jus; Villeneuve, A; Gautier, J.-F.; Pires, Anna Paula Batista de Ávila; Jm, Côté; K, Jus; Villeneuve, Roxane; Perron, Du

doi:10.1177/070674377301800116

Cited by 22 publications

(10 citation statements)

References 3 publications

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“…Studies performed on psychiatric patients mainly showed an increase of slow waves, slowing of the alpha rhythm, and the appearance of pathological patterns [Andreani et al, 1958;Kalinowsky and Hoch, 1961;Mayfield and Brown, 1966;Platman and Fieve, 1969;Johnson, 1969;Johnson et al, 1970;Helmchen and Kanowski, 1971;Itil and Akpinar, 1971;Bily et al, 1973;Gottschalk and Sack, 1973;Zakowska-Dabrowska and Rybakowski, 1973;Heninger, 1974;Okuma et al, 1974;Bente et al, 1982;Ulrich et al, 1982: Beaubernard et al, 1987, It should also be mentioned that the effect of lithium in epileptic patients remains controversial [Gershon, 1968;Erwin et al, 1973;Jus et al, 1973]. As for the serum lithium level measured in these dif ferent studies, it varied within as well as between studies considerably.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lithium on the EEG of Healthy Males and Females

Thau

Rappelsberger²,

Lovrek³

et al. 1988

Neuropsychobiology

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This study is based on 20 healthy volunteers (10 males and 10 females). Between 675 and 1,225 mg lithium carbonate per day was applied for 10 days. EEG was recorded before (day 0) and after lithium intake (day 10) with 19 electrodes and quantified by spectrum analyses. Absolute power and coherence values, between adjacent electrodes and between electrodes on homologous sites of both hemispheres, were computed for five frequency bands. For the evaluation of differences of the EEG parameters obtained on days 0 and 10, a nonparametric paired permutation test was applied. The obtained descriptive error probabilities were presented in topographic maps. Under lithium, the absolute power increased in the entire frequency range, but most distinct in the theta and beta 1 band. The local coherence analyses revealed a clear lateralization: increase in the left hemisphere and decrease in the right. The interhemispheric coherence decreased occipitally and frontally. A comparison of the EEG changes under lithium in males and females showed clear differences in the topographic distribution of power as well as coherence changes.

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Section: Discussionmentioning

confidence: 99%

Effect of Lithium on the EEG of Healthy Males and Females

Thau

Rappelsberger²,

Lovrek³

et al. 1988

Neuropsychobiology

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“…Controversy exists as to the proconvulsant properties of lithium, despite small open studies failing to demonstrate adverse effects in patients with epilepsy (374,375). Several studies have reported seizures in patients treated with lithium at both toxic (376)(377)(378)(379) and therapeutic serum levels (377,(380)(381)(382)(383)(384)(385). EEG changes have also been reported in patients (378,385,386) and in normal volunteers (387).…”

Section: Lithiummentioning

confidence: 99%

Depression in Epilepsy: Etiology, Phenomenology, and Treatment

1999

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Summary: A history of depression or depressive symptomatology has been reported in up to two-thirds of patients with medically intractable epilepsy, whereas community studies have demonstrated affective disorder only in a quarter of these patients. Depression has been reported peri-and interictally. However, differentiation may be difficult in patients with frequent seizures. Most authors have found no correlation between depression and epilepsy variables. However, complex partial seizures, especially of temporal lobe origin, appear to be etiologic factors, particularly in men with left-sided foci. Depression is also more common in patients treated with polytherapy especially with barbiturates, phenytoin, and vigabatrin. Depression has also been described de novo after temporal lobectomy. Psychosocial factors also play a part, but underlying risk factors (e.g., genetic, endocrine and metabolic) may explain the increased rates of depression in people with epilepsy compared to those with other neurologic and chronic medical conditions. The depression appears to be endogenous. Patients tend to exhibit fewer neurotic traits and more psychotic symptoms such as paranoia, delusions, and persecutory auditory hallucinations. Treatment approaches include psychotherapy, rationalization of antiepileptic drug medication, antidepressant treatment, and ECT. The tricyclic and related antidepressants appear to be epileptogenic, especially in people at high risk (personal or family history of seizures, abnormal pretreatment EEG, brain damage, alcohol or substance abuse/withdrawal and concurrent use of CNS-active medication). Seizures tend to occur early in treatment or after dose increments, especially if rapidly titrated. There is little evidence that the newer antidepressants, e.g., selective serotonin reuptake inhibitors, moclobemide, venlafaxine, or nefazodone are more epileptogenic than placebo.

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“…Jus et al 2 had randomly selected eight temporal lobe epileptics. The patients were kept on the traditional antiepileptic medications and lithium was added.…”

Section: Introductionmentioning

confidence: 99%

Lithium in Epilepsy

Kavallinis

1977

Clinical Electroencephalography

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IntroductionLithium is well known for its therapeutic effect in affective psychosis. The side effects are peculiar and the mode of action is not well understood. The most serious side effect is the induction of the clinical and EEG picture of diffuse encephalopathy. A case of deep coma has been reported with serium lithium of 1.76 mEq/L and cerebrospinal fluid level of 0.90 mEq/L,l .The effect of lithium in epilepsy is still debatable. Jus et al. 2 had randomly selected eight temporal lobe epileptics. The patients were kept on the traditional antiepileptic medications and lithium was added. It was concluded, that, "because the number of seizures increased in three patients, the behavior became impaired in four and the EEG pathology was augmented in five, the treatment was interrupted about two weeks following the administration of 600 mg. of lithium carbonate". The opposite conclusion was drawn by Erwin et al.: 3 , who tried lithium on 17 epileptics. Nine patients showed reduced discharge rate, seven patients did not change and one patient had an increase in frequency of EEG seizure activity, Gershon and Yurnllenreported, that, of 49 epileptics treated with lithium, 60% showed a decrease in seizure frequency. Others implicate lithium in the onset of status epilepticus in nonepileptic patients, when the lithium was used within the therapeutic range 5,6.

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Influence of Lithium Carbonate on Patients with Temporal Epilepsy

Cited by 22 publications

References 3 publications

Effect of Lithium on the EEG of Healthy Males and Females

Effect of Lithium on the EEG of Healthy Males and Females

Depression in Epilepsy: Etiology, Phenomenology, and Treatment

Lithium in Epilepsy

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