Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations

Yap, Siew Ping; Yuen, Kah Hay

doi:10.1016/j.ijpharm.2004.05.015

Cited by 74 publications

(51 citation statements)

References 20 publications

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“…Similar findings were observed with Yap et al's study (73), who reported the delivery of tocotrienols in SEDDS formulation caused faster onset of absorption with marked increase in the bioavailability of tocotrienols by 2-to 3-fold in humans (87). The authors explained the enhanced oral bioavailability by the sufficient droplet size, in submicron range, of the emulsion product formed as well as the enhanced rate and extent of lipolysis (87). Furthermore, Miyoshi et al investigated the effect of TRF inclusion complex with cyclodextrin (CD) on the oral bioavailability of γ-tocotrienol in mice (88).…”

Section: Strategies To Improve Vitamin E Oral Bioavailabilitysupporting

confidence: 90%

“…One of the possible explanations for the increased passive permeability by SLN and SEDDS could be related to the excipients incorporated in these delivery systems and their ability to modulate the fluidity of cell membrane (67,85,86). Similar findings were observed with Yap et al's study (73), who reported the delivery of tocotrienols in SEDDS formulation caused faster onset of absorption with marked increase in the bioavailability of tocotrienols by 2-to 3-fold in humans (87). The authors explained the enhanced oral bioavailability by the sufficient droplet size, in submicron range, of the emulsion product formed as well as the enhanced rate and extent of lipolysis (87).…”

Section: Strategies To Improve Vitamin E Oral Bioavailabilitysupporting

confidence: 74%

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Vitamin E Transporters in Cancer Therapy

Alqahtani

Kaddoumi

2014

AAPS J

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Abstract. Besides their potent antioxidant activity, vitamin E isoforms demonstrated multiple therapeutic activities among which is their activity against different cancer types, including breast, prostate, and colon cancers. However, the activity of vitamin E isoforms is limited by their low bioavailability following oral administration. In addition to the low solubility, vitamin E isoforms have been established as substrates for several intestinal and hepatic transport proteins. In this review, we present reported anticancer activity of vitamin E family members and the possible utilization of vitamin E and derivatives as chemosensitizers to reverse multidrug resistance when given as part of a delivery system and/or in combination with anticancer therapeutic drugs. Then, the review discusses disposition of vitamin E members and transport proteins that play a role in determining their systemic bioavailability followed by recent advances in vitamin E formulations and delivery strategies.

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Section: Strategies To Improve Vitamin E Oral Bioavailabilitysupporting

confidence: 90%

Section: Strategies To Improve Vitamin E Oral Bioavailabilitysupporting

confidence: 74%

Vitamin E Transporters in Cancer Therapy

Alqahtani

Kaddoumi

2014

AAPS J

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“…To date, several acute studies with oral supplementation of palm T3 in a single dose from 200 mg to 1011 mg did not report any acute adverse event (Yap et al, 2001;Yap and Yuen, 2004;Fairus et al, 2006). Also in chronic studies, long-term supplementation of T3 ranging from one month to five years did not report any events of discomfort or toxicities in the subjects investigated (Tomeo et al, 1995;Qureshi et al, 1997;Mensink et al, 1999;Nesaretnam et al, 2010;Zaiden et al, 2010;Mahalingam et al, 2011;Yuen et al, 2011;Heng et al, 2013).…”

Section: Ramdomised (N=32) (16 Males and 16 Females)mentioning

confidence: 99%

Safety Assessment of Tocotrienol Supplementat Ion in Subjects With Metabolic Syndrome: A Randomised Control Trial

Gan¹,

Lai²,

Chew³

et al. 2016

JOPR

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“…In vivo and human studies indicated that tocotrienols when given in diet cannot be absorbed completely unlike tocopherols. However, there are some solubility and transportation issues regarding the oral administration of tocotrienols limiting their bio-availability and anti-cancer activity [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Natural Sources of Tocotrienols: A Note on Absorption

Kabir¹,

Adnan²,

Rahman³

2017

J In Silico In Vitro Pharmacol

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Tocotrienols are the major interest of research for their various biological potentials including anticancer activity. They belong to the Vitamin E group of compounds consisting of four isomers. They are obtained from various natural sources including palm oil, rice bran oil, and annatto. However, consuming these sources through diet cannot achieve the desired therapeutic effect due to the poor absorption and distribution of the tocotrienols through gut. It is being challenging since years to increase the bioavailability of tocotrienols so that they can be efficiently taken in the diet. Being lipophilic, they can be absorbed considerably well in the presence of food. Several human and in vivo animal studies indicated the potential of tocotrienols in various medical conditions such as cancer, neuro protection and inflammation. Rigorous research is needed to make them available for the public consumption with proper formulating techniques.

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Influence of lipolysis and droplet size on tocotrienol absorption from self-emulsifying formulations

Cited by 74 publications

References 20 publications

Vitamin E Transporters in Cancer Therapy

Vitamin E Transporters in Cancer Therapy

Safety Assessment of Tocotrienol Supplementat Ion in Subjects With Metabolic Syndrome: A Randomised Control Trial

Natural Sources of Tocotrienols: A Note on Absorption

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