Influence of light on growth, conidiation and fumonisin production by Fusarium verticillioides

Fanelli, Francesca; Schmidt‐Heydt, Markus; Haidukowski, Miriam; Susca, Antonia; Geisen, Rolf; Logrieco, A.; Mulé, Giuseppina

doi:10.1016/j.funbio.2011.11.007

Cited by 36 publications

(19 citation statements)

References 42 publications

(43 reference statements)

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“…Recently, Fanelli et al . () presented that white pulsing light inhibits fumonisin biosynthesis in F. verticillioides with the reduction of FUM gene expression. In this study, we also found that light has inhibition effects on the production of trichothecenes by F. graminearum .…”

Section: Discussionmentioning

confidence: 99%

“…(Chaudhary and Prasad ; Das and Busse ; Fanelli et al . ), the general features of conidiation regulated by light cannot be interpreted because of variations in strains, experimental approaches and culture conditions (Avalos and Estrada ). For example, conidiation was stimulated by light in the F. fujikuroi wild‐type strain IMI58289 (Avalos et al .…”

Section: Discussionmentioning

confidence: 99%

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Effects of light on secondary metabolism and fungal development of Fusarium graminearum

2013

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Aims: The objectives of this study were (i) to characterize white-collar (WC) orthologues of the filamentous fungus Fusarium graminearum, (ii) to investigate light-responsive phenotypes by the deletion of Fgwc-1 and Fgwc-2 genes and (iii) to examine the roles of those genes in constant light and darkness in relation to secondary metabolite synthesis and development. Methods and Results: Production of secondary metabolites and asexual/sexual development of deletion mutants, DFgwc-1 and DFgwc-2, were assessed in constant light and darkness compared to the wild-type strain. The results showed that deletion of Fgwc-1 and Fgwc-2 impaired early onset of carotenogenesis, photoreactivation and the maturity of perithecia during sexual development. Conidiation of the DFgwc-1 and DFgwc-2 mutants was derepressed in constant light, but not in darkness. Moreover, the individual mutants produced more aurofusarin and trichothecenes than the wild-type strain in both constant light and darkness. Conclusions: Both Fgwc-1 and Fgwc-2 are required for light-dependent processes in F. graminearum, whereas light-independent processes such as aurofusarin and trichothecene biosynthesis are derepressed by deletion of these genes. Thus, Fgwc-1 and Fgwc-2 play roles as positive and negative regulators, depending on the requirement of light for biological activity. Significance and Impact of the Study: These results will extend the knowledge of the photobiology of Fusarium graminearum and will increase current understanding of light regulatory mechanisms mediated by white collar in secondary metabolism and fungal development.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of light on secondary metabolism and fungal development of Fusarium graminearum

2013

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“…Two research groups have recently published the results of their studies on the VeA homologue (FgVEA and FgVE1) in F. graminearum (Jiang et al, 2011;Merhej et al, 2012). In F. verticillioides, Fanelli et al (2012) showed that expression of FvVE1 is affected by light, as observed with A. nidulans. Even though FgVEA and FgVE1 designate the same gene (FGSG_11955) in F. graminearum genome, the authors reported contrasting effects on conidia production and germination in their mutant strains.…”

Section: Epigenetic Regulationmentioning

confidence: 97%

Aflatoxins, fumonisins, and trichothecenes: a convergence of knowledge

2013

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Plant pathogenic fungi Aspergillus flavus, Fusarium verticillioides, and Fusarium graminearum infect seeds of the most important food and feed crops, including maize, wheat, and barley. More importantly, these fungi produce aflatoxins, fumonisins, and trichothecenes, respectively, which threaten health and food security worldwide. In this review, we examine the molecular mechanisms and environmental factors that regulate mycotoxin biosynthesis in each fungus, and discuss the similarities and differences in the collective body of knowledge. Whole-genome sequences are available for these fungi, providing reference databases for genomic, transcriptomic, and proteomic analyses. It is well recognized that genes responsible for mycotoxin biosynthesis are organized in clusters. However, recent research has documented the intricate transcriptional and epigenetic regulation that affects these gene clusters. Significantly, molecular networks that respond to environmental factors, namely nitrogen, carbon, and pH, are connected to components regulating mycotoxin production. Furthermore, the developmental status of seeds and specific tissue types exert conditional influences during fungal colonization. A comparison of the three distinct mycotoxin groups provides insight into new areas for research collaborations that will lead to innovative strategies to control mycotoxin contamination of grain.

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“…Still, other species must likely integrate oppositional light signals in order to mediate a proper response. In Fusarium verticilloides , for example, white light promotes conidiation even though red and short-wave blue light are inducing while longer-wave length blue light is repressive (Fanelli et al 2012). …”

Section: Light As a Signal For Spacementioning

confidence: 99%

Fungal photobiology: visible light as a signal for stress, space and time

2014

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Visible light is an important source of energy and information for much of life on this planet. Though fungi are neither photosynthetic nor capable of observing adjacent objects, it is estimated that the majority of fungal species display some form of light response, ranging from developmental decision making to metabolic reprogramming to pathogenesis. As such, advances in our understanding of fungal photobiology will likely reach the broad fields impacted by these organisms, including agriculture, industry and medicine. In this review, we will first describe the mechanisms by which fungi sense light and then discuss the selective advantages likely imparted by their ability to do so.

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Influence of light on growth, conidiation and fumonisin production by Fusarium verticillioides

Cited by 36 publications

References 42 publications

Effects of light on secondary metabolism and fungal development of Fusarium graminearum

Effects of light on secondary metabolism and fungal development of Fusarium graminearum

Aflatoxins, fumonisins, and trichothecenes: a convergence of knowledge

Fungal photobiology: visible light as a signal for stress, space and time

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