Influence of light at night on murine anxiety- and depressive-like responses

Fonken, Laura K.; Finy, M. Sima; Walton, James C.; Weil, Zachary M.; Workman, Joanna L.; Ross, Jessica L.; Nelson, Randy J.

doi:10.1016/j.bbr.2009.07.001

Cited by 180 publications

(150 citation statements)

References 41 publications

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“…In previous reports, exposure to light at nighttime, irrespective of the light-dark cycle, was shown to disturb brain functions by disturbing the circadian rhythm [21] Journal of Behavioral and Brain Science [22]. Disturbance of the circadian rhythm is a risk factor for type 2 diabetes, bipolar disease, and synaptic plasticity dysfunction in the hippocampus [23] [24] [25].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Blue LED Light on Behavior and Retinal Function in Maternal and Offspring Mice

Horibe¹,

Yoshino²,

Domoto³

et al. 2017

JBBS

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In the present study, we investigated whether blue light emission diode (LED) light exposure affects the maternal behavior of mice. The brain function of the offspring mice, including short-term memory, locomotor activity, anxiety-like behavior, and depression-like behavior, was evaluated. Pregnant mice at day 11 were housed in the apparatus for exposure to blue LED light during the daytime. Nesting behavior and the survival of pups were observed until weaning. After weaning, the offspring mice were bred in normal light conditions until 12 weeks old, and then the Y-maze test, open field test, and tail suspension test were performed. Retinal functions were evaluated by electroretinogram and histological analysis. Blue LED light exposure during the daytime induced retinal damage, but did not affect behavior related to maternal care in maternal mice. In the offspring mice, blue LED light exposure during the daytime did not affect the retina or brain functions. These findings suggest that blue LED light during the daytime might not be a risk factor for disruption of the mother-infant relationship or offspring brain development in mice.

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Section: Discussionmentioning

confidence: 99%

The Effects of Blue LED Light on Behavior and Retinal Function in Maternal and Offspring Mice

Horibe¹,

Yoshino²,

Domoto³

et al. 2017

JBBS

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“…This affects many physiological and behavioral functions [8] . Sustained night-time illumination increases the risk of heart diseases [9] , cancer [10] and causes sleep and mood disturbances [11] . Nocturnal lighting, if sufficiently bright, disrupts the synthesis of melatonin [12] .…”

Section: Introductionmentioning

confidence: 99%

Histological and Immunohistochemical Study on the Effect of Constant Light Exposure on T Lymphocyte Subsets in the Thymus and Lymph Node of Male Albino Rats

Rifaai

Baky

2017

Egyptian Journal of Histology

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Background: Today there is a widespread exposure to high levels of light at night. . This causes divergence from the natural environment and leads to significant implications on the circadian rhythm. Constant light exposure inhibits melatonin secretion and increases serum concentration of corticosterone. The immune system is very sensitive to stress. Aim of the Work: to study the effect of chronic exposure to constant light (as a model of stress) on the T lymphocytes populations and distribution in the thymus and lymph node. Material and Methods: animals were divided into two groups (10 rats each). The 1st group considered as control group, was kept on a day light-darkness for 12-12 h. The 2nd group was kept under complete artificial light for a period of 4 weeks. Thymus glands and the cervical lymph nodes of rats were removed and processed for haematoxylin and eosin, and immunohistochemical staining for CD3, CD4 and CD8. Results: lymphocytic depletion was noticed in the thymus and lymph nodes of the constant light exposed group. Also the distribution of CD3 and CD4 positive cells were altered in the lymph node of the same group. Conclusion: Constant light stress causes lymphocytic depletion and alters lymphoid cell subsets distribution both in the thymus and lymph nodes.

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“…Both features of a depressive-like state are likely to occur in parallel (Fonken et al, 2009;Snyder et al, 2011). For example, anhedonia-like behavior defined by a decrease in sucrose intake and preference in chronically stressed C57BL/6N mice accompanies an increase in floating during forced swimming and immobility behavior in the modified tail suspension test (Strekalova et al, 2004;Strekalova and Steinbusch, 2010;Kanarik et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression

Malatyńska

Steinbusch

Redkozubova

et al. 2012

Experimental Gerontology

103

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The prevalence of depression increases with aging. We hypothesized that like humans, old animals exhibit anhedonic-like behavior, along with signs of behavioral despair. In rodents, anhedonia, a reduced sensitivity to reward, which is listed as a core feature of major depression in the DSM-IVR, can be measured by a decrease in intake of and preference for sweet solutions. Here, sucrose intake, forced swimming, immobility in the modified tail suspension test, novelty exploration, grooming, anxiety and locomotor activity were compared in naïve 3-and 18-month-old male C57BL/6 mice. The absolute amounts and the ratio of consumed 1% sucrose solution to water intake was significantly smaller in 18-month-old mice than in 3-month-old mice. The consumption of 5%-sucrose solution requiring high levels of drinking effort, novelty exploration in two setups and grooming behavior in the splash test were reduced in older animals. Analysis of other behaviors suggested that the above-mentioned signs of anhedonic-like traits were unlikely to be attributable to the potential effect of aging on metabolic needs for water, taste perception, motor capabilities or the induction of essential anxiety and neophobia. A 4-week treatment with the antidepressant imipramine (7 mg/kg/day) or dimebon, a compound with suggested neuroprotective proneurogenic properties (1 mg/kg/day) restored sucrose intake and preference in 18-month-old mice. Meanwhile, young and old mice showed no differences in the parameters of behavioral despair evaluated in the forced swim and modified tail suspension tests. Thus, the behavioral profile of aged mice parallels that of humans with elderly depression, in whom the symptoms of hedonic deficits typically outweigh affective disturbances. The assessment of anhedonic-like traits with the sucrose preference test in 18-month-old mice will be useful in preclinical studies of elderly depression.

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Influence of light at night on murine anxiety- and depressive-like responses

Cited by 180 publications

References 41 publications

The Effects of Blue LED Light on Behavior and Retinal Function in Maternal and Offspring Mice

The Effects of Blue LED Light on Behavior and Retinal Function in Maternal and Offspring Mice

Histological and Immunohistochemical Study on the Effect of Constant Light Exposure on T Lymphocyte Subsets in the Thymus and Lymph Node of Male Albino Rats

Anhedonic-like traits and lack of affective deficits in 18-month-old C57BL/6 mice: Implications for modeling elderly depression

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