Influence of Levodopa on Serum Levels of Anterior Pituitary Hormones in Man

Boden, Günther; Lundy, Laurence E.; Owen, Oliver E.

doi:10.1159/000122100

Cited by 19 publications

(8 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A reduction in gonadotrophins following i.-Dopa, however, has not been uniformly observed (Boden et al 1972;Hayek Sc Crawford 1972;Zarate et al 1973). …”

Section: Discussionmentioning

confidence: 99%

Failure of Metoclopramide to Influence Lh, FSH and TSH Secretion or Their Responses to Releasing Hormones

Spitz¹,

Trestian²,

Cohen

et al. 1979

Acta Endocrinologica

View full text Add to dashboard Cite

Intravenous metoclopramide (MET) (10 mg) induced a brisk PRL response with a mean \ m=+-\ sem peak of 85.3 \ m=+-\ 7.7 ng/ml maximal at 30 min. l-Dopa, but not atropine pre-treatment, attenuated the prolactin (PRL) response to MET. This indicates that the antidopaminergic properties of MET mediate PRL secretion. MET did not influence basal levels of TSH, LH or FSH. Neither did it affect their response to the respective releasing hormones. Our results indicate that dopaminergic blockade induced by iv MET, does not influence the secretion of the pituitary glycoprotein hormones.Dopamine, together with the other monoamines serotonin and noradrenaline modulates the secretion of the hypothalamic releasing hormones (Frohman 8c Stachura 1975). In addition, both in vivo and in vitro studies have shown that dopamine can act directly at the level of the pituitary to inhibit the

show abstract

“…A reduction in gonadotrophins following i.-Dopa, however, has not been uniformly observed (Boden et al 1972;Hayek Sc Crawford 1972;Zarate et al 1973). …”

Section: Discussionmentioning

confidence: 99%

Failure of Metoclopramide to Influence Lh, FSH and TSH Secretion or Their Responses to Releasing Hormones

Spitz¹,

Trestian²,

Cohen

et al. 1979

Acta Endocrinologica

View full text Add to dashboard Cite

show abstract

“…One study showed that oral administration of levodopa significantly decreased circulating LH concentrations in normal men (48). However, in a subsequent report, infusions of L-dopa or serotonin in normal men did not suppress serum LH concentrations (49).…”

Section: Neurohumoral Regulation Of Pulsatile Lh Release In Manmentioning

confidence: 97%

Contemporary Aspects of Discrete Peak-Detection Algorithms. I. The Paradigm of the Luteinizing Hormone Pulse Signal in Men*

et al. 1988

View full text Add to dashboard Cite

“…Studies in man have yielded conflicting results, the majority of studies being performed with only one adrenergic drug and the conclusions some¬ times differing significantly (Boden et al 1972;Polansky et al 1976;Leblanc et al 1976;Lachelin et al 1977). Our study, employing many DA-ergic agents, indicates that whatever the DA-ergic agent employed, DA-ergic drugs as a group inhibit LH release, and makes possible some interpretation on the mode of action of DA and DA-ergic drugs in lowering LH levels.…”

Section: Discussionmentioning

confidence: 62%

“…In human beings 1-dopa, the biological precursor of DA, has been shown by some authors (Boden et al 1972;Leblanc et al 1976;Lachelin et al 1977) to inhibit LFI release or to be without effect (Polanskietal. 1976).…”

mentioning

confidence: 99%

Interaction of dopaminergic and antiserotoninergic drugs in the control of prolactin and LH release in normal women

Pontiroli

Alberetto

Pellicciotta

et al. 1980

Acta Endocrinologica

View full text Add to dashboard Cite

Prolactin (Prl) release, both in the experimental animal and in man, is stimulated by serotonin (5HT) and inhibited by dopamine (DA). Data also suggest that LH release in the animal is stimulated by norepinephrine and inhibited by DA. The role of 5HT in the control of LH release is less clear. It would appear to stimulate episodic LH release and to inhibit the LH surge at the pro-oestrus in animals, but the effect of 5HT on LH release has not yet been evaluated in man. In the present paper we have studied the effect of various DA-ergic drugs (DA, iv 1-dopa, po 1-dopa and bromoergocriptine) and of two anti-5HT drugs, metergoline and methysergide, on Prl and LH release in normal women. DA-ergic drugs lowered plasma Prl and LH levels; anti-5HT drugs, at doses able to lower Prl levels, did not affect basal LH release nor the inhibiting effect of iv 1-dopa on LH release. These data indicate that DA inhibits both LH and Prl release in normal women, and that 5HT stimulates Prl release but is not involved in the regulation of LH secretion. The fact that, at variance to all the DA\x=req-\ ergic drugs used, the two anti-5HT drugs did not vary LH release, suggests that metergoline and methysergide are devoid of DA-ergic activity in man, at least at the doses able to inhibit Prl release.

show abstract

Influence of Levodopa on Serum Levels of Anterior Pituitary Hormones in Man

Cited by 19 publications

References 4 publications

Failure of Metoclopramide to Influence Lh, FSH and TSH Secretion or Their Responses to Releasing Hormones

Failure of Metoclopramide to Influence Lh, FSH and TSH Secretion or Their Responses to Releasing Hormones

Contemporary Aspects of Discrete Peak-Detection Algorithms. I. The Paradigm of the Luteinizing Hormone Pulse Signal in Men*

Interaction of dopaminergic and antiserotoninergic drugs in the control of prolactin and LH release in normal women

Contact Info

Product

Resources

About