Influence of leukotriene biosynthesis inhibition on heart rate in patients with atrial fibrillation

Sokołowska, Barbara; Dropiński, Jerzy; Rzeszutko, Marcin; Szczeklik, Wojciech; Sanak, Marek; Szczeklik, Andrzej

doi:10.1016/j.ijcard.2010.09.038

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…To the best of our knowledge, this is the first report of the effect of zileuton on reperfusion-induced ventricular arrhythmias. This finding is in line with the results of a recent clinical study 23 in which zileuton treatment decreased the number of tachycardia events in patients with permanent atrial fibrillation.…”

Section: Discussionsupporting

confidence: 91%

The Effects of Zileuton and Montelukast in Reperfusion-Induced Arrhythmias in Anesthetized Rats

Gonca

2013

Current Therapeutic Research

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Background5-Lipoxygenase is an enzyme involved in the synthesis of leukotriene eicosanoids from arachidonic acid. The therapeutic potential of zileuton, an inhibitor of 5-lipoxygenase, and montelukast, a cysteinyl leukotriene receptor antagonist, for the treatment of ischemia/reperfusion (I/R) injury of the heart has been proposed in a few studies. However, the effects of zileuton and montelukast on I/R-induced arrhythmias have not been determined.ObjectiveWe assessed the possible protective effects of zileuton and montelukast against I/R-induced arrhythmias.MethodsForty-five male Wistar albino rats were divided into 5 groups, each containing 9 rats. Group 1: control, Groups 2 and 3: rats treated with montelukast (10 and 30 mg/kg IP); and Groups 4 and 5: rats treated with zileuton (1 and 3 mg/kg IV) 15 minutes before the induction of ischemia. Ischemia and reperfusion were induced by occluding the left main coronary artery of anesthetized rats for 6 minutes followed by reopening the artery for 6 minutes.ResultsBoth doses of zileuton decreased the mean [SE] arrhythmia score (zileuton 1 mg/kg: 1.4 [0.8]; zileuton 3 mg/kg: 1.3 [0.5] vs control: 2.9 [0.3]; P < 0.05), the duration of ventricular tachycardia, and the total length of arrhythmias, but montelukast was not effective to decrease the ventricular arrhythmias during the 6 minutes of reperfusion.ConclusionsThe results indicate for the first time that zileuton exerts an antiarrhythmic effect at different doses and that montelukast is not effective against I/R-induced arrhythmias. These results indicate that zileuton may be a candidate for drug treatment of I/R-induced arrhythmias.

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Section: Discussionsupporting

confidence: 91%

The Effects of Zileuton and Montelukast in Reperfusion-Induced Arrhythmias in Anesthetized Rats

Gonca

2013

Current Therapeutic Research

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“…The synthesis of LOX metabolites in granuloma is increased in smokers, who also show significant qualitative and quantitative differences in the profile of eicosanoids . It is well known that these compounds modulate a series of pathways with influence on hypertension , tachycardia , reduced cardiac output , cholesterol accumulation , vessel damage , and clot formation . Also, HETE levels are elevated in chronic smokers with no further increase by acute smoking .…”

Section: Resultsmentioning

confidence: 99%

Targeted analysis of omega‐6‐derived eicosanoids in human serum by SPE‐LC‐MS/MS for evaluation of coronary artery disease

et al. 2013

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A targeted approach has been applied to quantitative analysis of eicosanoids derived from omega‐6 fatty acids in serum from individuals diagnosed with coronary artery disease (CAD). The target metabolites were series‐2 prostaglandins, thromboxane B2, hydroxy‐eicosatetraenoic acids, and hydroxyoctadecadienoic acids. The method was based on SPE‐LC‐MS/MS in selected reaction monitoring mode for highly selective and sensitive determination of the target eicosanoids. The combination of SPE and LC‐MS/MS involved the benefits from both direct analysis of serum without a step for protein precipitation and fully automation of the analysis. The method allowed comparison of omega‐6‐derived eicosanoids in serum from patients diagnosed with CAD and from control individuals. The effect of treatment with aspirin on the profile of the target compounds was evaluated through its incidence on the different pathways. Finally, the serum levels of the target metabolites in patients diagnosed with CAD were also statistically examined according to the severity of the coronary lesion stratified as stable angina, non‐ST‐elevation acute coronary syndrome, and acute myocardial infarction.

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“…Cigarette smoke is a complex mixture of molecules, each with a distinct pharmacological response. Nevertheless, many direct influences of habitual smoking promoting heart disease are modulated by eicosanoids: hypertension [89, 119], tachycardia [120–123], reduced cardiac output [124], cholesterol accumulation [125], vessel damage [126], and promotion of clot formation [127]. …”

Section: Smoking and Oxidative Stressmentioning

confidence: 99%

An eicosanoid-centric view of atherothrombotic risk factors

Gleim

Stitham

Tang

et al. 2012

Cell. Mol. Life Sci.

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Influence of leukotriene biosynthesis inhibition on heart rate in patients with atrial fibrillation

Cited by 9 publications

References 12 publications

The Effects of Zileuton and Montelukast in Reperfusion-Induced Arrhythmias in Anesthetized Rats

The Effects of Zileuton and Montelukast in Reperfusion-Induced Arrhythmias in Anesthetized Rats

Targeted analysis of omega‐6‐derived eicosanoids in human serum by SPE‐LC‐MS/MS for evaluation of coronary artery disease

An eicosanoid-centric view of atherothrombotic risk factors

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