Influence of Leishmania RNA Virus 1 on Proinflammatory Biomarker Expression in a Human Macrophage Model of American Tegumentary Leishmaniasis

Kariyawasam, Ruwandi; Grewal, Jugvinder; Lau, Rachel; Purssell, Andrew; Valencia, Braulio M.; Llanos-Cuentas, Alejandro; Boggild, Andrea K.

doi:10.1093/infdis/jix416

Cited by 20 publications

(42 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After reading the full text of the articles, 17 papers were included in our systematic review and meta‐analysis (Tarr et al, ; Widmer et al, ; Saiz et al, ; Guilbride et al, ; Ogg, Carrion, J.r. R., Botelho, A.C., Mayrink, W., Correa‐Oliveira, R., Patterson, & J.L., ; Pereira, ; Valencia et al, ; Zangger et al, ; Adaui et al, ; Bourreau et al, ; Cantanhede et al, ; Ito et al, ; Ginouvès et al, ; Hajjaran et al, ; Macedo et al, ; Sukla, Roy, Sundar, & Biswas, ; Kariyawasam et al, ).…”

Section: Resultsmentioning

confidence: 99%

“…Considering the observation of LRV2 in L. major , L. aethiopica and L. infantum in OWL outside of South America, these data suggest that LRV appeared before the divergence of the L. ( Leishmania ) and ( Viannia ) subgenera (Zangger et al, ). In the New World (in regions of Central and South America), in L. Viannia complex, LRV has been detected in strains of L. (Viannia) guyanensis , L. (Viannia) braziliensis , L. (Viannia) panamensis , L. (Viannia) lainsoni and L. V. amazonensis from L. mexicana complex (Cantanhêde et al, ; Kariyawasam et al, ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Global status of synchronizing Leishmania RNA virus in Leishmania parasites: A systematic review with meta‐analysis

Saberi

Fakhar

Mohebali

et al. 2019

Transbound Emerg Dis

View full text Add to dashboard Cite

Leishmaniasis is one of the most neglected tropical diseases caused by protozoan parasites belonging to the genus Leishmania. There is much evidence regarding prevalence of Leishmania RNAvirus (LRV) causing Old World leishmaniasis (OWL) and New World leishmaniasis (NWL); however, a combined evidence‐based knowledge on this topic is not still available. The purpose of this systematic review and meta‐analysis was to address the global status of synchronizing LRV in Leishmania in the available literature. The data were systematically collected from the English electronic databases up to May 2018. Then, the studies were screened based on the inclusion and exclusion criteria. The random‐effect model was used by forest plot with 95% confidence interval (CI). Overall, 877 samples from 17 articles were included in this study. Given species of Leishmania, the highest prevalence of LRV belonged to Leishmania (L.) Viannia (V.) guyanensis and L. V. braziliensis. Additionally, the virus was detected also in L. V. amazonensis, L. V. panamanensis, L. V. lainsoni, L. aethiopica, L. major and L. infantum. By random‐effect model, the global prevalence of LRV was estimated to be 26.2% (95% CI: 14.4% ‐ 40.1%). The high prevalence of LRV among causative agents of NWLisolated from the metastatic clinical forms suggests potential association of LRV with metastatic clinical forms in New World endemic regions. A comprehensive investigation on experimental and clinical aspects of LRV is needed to fully appraise the role of these viruses in pathogenicity of Leishmania parasites and their drug resistance.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Global status of synchronizing Leishmania RNA virus in Leishmania parasites: A systematic review with meta‐analysis

Saberi

Fakhar

Mohebali

et al. 2019

Transbound Emerg Dis

View full text Add to dashboard Cite

show abstract

“…Recently, the presence of LRV1 in L. (V) panamensis isolates from Ecuador and Costa Rica was reported showing that LRV1 is broadly spread into Leishmania species from the Viannia subgenus at the north of the Amazon Region (15).…”

Section: Discussionmentioning

confidence: 99%

“…At the epidemiologic level, LRV1/2 has been found at frequencies ranging from 0 to 87% in clinical samples from patients with leishmaniasis (15, 17, 19–33); the strength of the association between viral presence and complication development varies according to the study (24, 28) and among different South-American Regions (30). The wide range in LRV1 frequency of detection in clinical samples may reflect diverse experimental approaches that do not account for differences in clinical specimens.…”

Section: Introductionmentioning

confidence: 99%

Toward an objective diagnostic for detection of Leishmania RNA virus (LRV) in clinical samples from cutaneous leishmaniasis patients

Parra-Muñoz

Aponte

Ovalle-Bracho

et al. 2018

Preprint

View full text Add to dashboard Cite

18Leishmania RNA virus (LRV) is a double strand RNA virus belonging to the was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.1101/338095 doi: bioRxiv preprint first posted online Jun. 4, 2018; 2 and treatment failure of cutaneous leishmaniasis (TFCL). However, the reported

show abstract

“…LRV-sequences were also detected in an Iranian L. infantum clinical isolate from a patient unresponsive to antimonial treatment (7). Viral coinfections and presence of Leishmania RNA virus are therefore increasingly perceived as risk factors for pathogenicity of human leishmaniasis (5,(7)(8)(9). The virus appears to use the Leishmania exosomal pathway to reach the extracellular environment (10).…”

Section: Introductionmentioning

confidence: 99%

Interferon Alpha Favors Macrophage Infection by Visceral Leishmania Species Through Upregulation of Sialoadhesin Expression

et al. 2020

View full text Add to dashboard Cite

Type I interferons (IFNs) induced by an endogenous Leishmania RNA virus or exogenous viral infections have been shown to exacerbate infections with New World Cutaneous Leishmania parasites, however, the impact of type I IFNs in visceral Leishmania infections and implicated mechanisms remain to be unraveled. This study assessed the impact of type I IFN on macrophage infection with L. infantum and L. donovani and the implication of sialoadhesin (Siglec-1/CD169, Sn) as an IFN-inducible surface receptor. Stimulation of bone marrow-derived macrophages with type I IFN (IFN-α) significantly enhanced susceptibility to infection of reference laboratory strains and a set of recent clinical isolates. IFN-α particularly enhanced promastigote uptake. Enhanced macrophage susceptibility was linked to upregulated Sn surface expression as a major contributing factor to the infection exacerbating effect of IFN-α. Stimulation experiments in Sn-deficient macrophages, macrophage pretreatment with a monoclonal anti-Sn antibody or a novel bivalent anti-Sn nanobody and blocking of parasites with soluble Sn restored normal susceptibility levels. Infection of Sn-deficient mice with bioluminescent L. infantum promastigotes revealed a moderate, strain-dependent role for Sn during visceral infection under the used experimental conditions. These data indicate that IFN-responsive Sn expression can enhance the susceptibility of macrophages to infection with visceral Leishmania promastigotes and that targeting of Sn may have some protective effects in early infection.

show abstract

Influence of Leishmania RNA Virus 1 on Proinflammatory Biomarker Expression in a Human Macrophage Model of American Tegumentary Leishmaniasis

Cited by 20 publications

References 28 publications

Global status of synchronizing Leishmania RNA virus in Leishmania parasites: A systematic review with meta‐analysis

Global status of synchronizing Leishmania RNA virus in Leishmania parasites: A systematic review with meta‐analysis

Toward an objective diagnostic for detection of Leishmania RNA virus (LRV) in clinical samples from cutaneous leishmaniasis patients

Interferon Alpha Favors Macrophage Infection by Visceral Leishmania Species Through Upregulation of Sialoadhesin Expression

Contact Info

Product

Resources

About