Influence of l-glutamic acid on binding of interleukin-1β, tumour necrosis factor-α and interleukin-6 to HL-60 cells

L-Glutamic Acid Modulates the Cytotoxic Effect of Tumor Necrosis Factor on the HL-60 Cell Line

“…We conclude on the basis of these results and the data published earlier [14][15][16] that L -glutamic acid simultaneously inhibits apoptotic and NF-κ B -activating cascades induced by TNF-α and increases the differentiating effect of this cytokine. Therefore, the next stage of our studies was the search for the mechanism of transduction of the differentiating signal in cell.…”

“…Previously, we have already shown that the specific glutamate receptors were absent on the surface of the HL-60 cells [14][15][16]. In this case, L-glutamic acid decreases the reception of cytokines regulating proliferation (interleukin 1β, interleukin 6, and γ-interferon) with a simultaneous increase in the number of binding sites for TNF-α on the cell surface.…”

“…Previously, we studied the differentiating effect of glutamic acid on the HL-60 cells of promyelocyte human leukemia and demonstrated that no specific glutamate receptors are present on the membranes of HL-60 cells [14][15][16]. The differentiating effect of L -GluOH is associated with a decrease in the proliferating signal induced by such cytokines as interleukin 1 β , interleukin 6, and γ -interferon and with an increase in the differentiating activity of TNF-α .…”