Influence of l-Dopa adsorption time and concentration on Au nanorods aggregation for SERS quantitative analysis

Oliveira, Tatiana Aparecida de; Martin, Cibely S.; Rubira, Rafael J. G.; Barros, Anerise de; Mazali, Ítalo Odone; Constantino, Carlos J. L.

doi:10.1016/j.cap.2023.08.002

Cited by 2 publications

(1 citation statement)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although SERS promises impressive sensitivity and selectivity, it requires specialized and complex equipment. Nonetheless, it remains a widely popular technique for neurotransmitter detection [ 30 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 ]. In recent works, research teams are exploring implantable SERS-based nanoprobes for direct neurotransmitter detection in the brain [ 69 , 102 , 103 , 104 , 105 ].…”

Section: In Vivo Neurotransmitter Sensing Techniquesmentioning

confidence: 99%

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

Lachance,

Gauvreau,

Boisselier

et al. 2024

Sensors

View full text Add to dashboard Cite

Neurotransmitter analysis plays a pivotal role in diagnosing and managing neurodegenerative diseases, often characterized by disturbances in neurotransmitter systems. However, prevailing methods for quantifying neurotransmitters involve invasive procedures or require bulky imaging equipment, therefore restricting accessibility and posing potential risks to patients. The innovation of compact, in vivo instruments for neurotransmission analysis holds the potential to reshape disease management. This innovation can facilitate non-invasive and uninterrupted monitoring of neurotransmitter levels and their activity. Recent strides in microfabrication have led to the emergence of diminutive instruments that also find applicability in in vitro investigations. By harnessing the synergistic potential of microfluidics, micro-optics, and microelectronics, this nascent realm of research holds substantial promise. This review offers an overarching view of the current neurotransmitter sensing techniques, the advances towards in vitro microsensors tailored for monitoring neurotransmission, and the state-of-the-art fabrication techniques that can be used to fabricate those microsensors.

show abstract

Section: In Vivo Neurotransmitter Sensing Techniquesmentioning

confidence: 99%

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

Lachance,

Gauvreau,

Boisselier

et al. 2024

Sensors

View full text Add to dashboard Cite

show abstract

Surface-Enhanced Raman Scattering Nanosensing and Imaging in Neuroscience

Boudries,

Williams,

Paquereau--Gaboreau

et al. 2024

ACS Nano

View full text Add to dashboard Cite

Monitoring neurochemicals and imaging the molecular content of brain tissues in vitro, ex vivo, and in vivo is essential for enhancing our understanding of neurochemistry and the causes of brain disorders. This review explores the potential applications of surface-enhanced Raman scattering (SERS) nanosensors in neurosciences, where their adoption could lead to significant progress in the field. These applications encompass detecting neurotransmitters or brain disorders biomarkers in biofluids with SERS nanosensors, and imaging normal and pathological brain tissues with SERS labeling. Specific studies highlighting in vitro, ex vivo, and in vivo analysis of brain disorders using fit-for-purpose SERS nanosensors will be detailed, with an emphasis on the ability of SERS to detect clinically pertinent levels of neurochemicals. Recent advancements in designing SERS-active nanomaterials, improving experimentation in biofluids, and increasing the usage of machine learning for interpreting SERS spectra will also be discussed. Furthermore, we will address the tagging of tissues presenting pathologies with nanoparticles for SERS imaging, a burgeoning domain of neuroscience that has been demonstrated to be effective in guiding tumor removal during brain surgery. The review also explores future research applications for SERS nanosensors in neuroscience, including monitoring neurochemistry in vivo with greater penetration using surface-enhanced spatially offset Raman scattering (SESORS), near-infrared lasers, and 2-photon techniques. The article concludes by discussing the potential of SERS for investigating the effectiveness of therapies for brain disorders and for integrating conventional neurochemistry techniques with SERS sensing.

show abstract

Influence of l-Dopa adsorption time and concentration on Au nanorods aggregation for SERS quantitative analysis

Cited by 2 publications

References 37 publications

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

Breaking Barriers: Exploring Neurotransmitters through In Vivo vs. In Vitro Rivalry

Surface-Enhanced Raman Scattering Nanosensing and Imaging in Neuroscience

Contact Info

Product

Resources

About