Influence of Kinship and MHC Class II Genotype on Visual Traits in Zebrafish Larvae (Danio rerio)

Hinz, Cornelia; Gebhardt, Katharina; Hartmann, Alexander K.; Sigman, Lauren; Gerlach, Gabriele

doi:10.1371/journal.pone.0051182

Cited by 15 publications

(10 citation statements)

References 23 publications

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“…Finally, orthologs of mammalian vasopressin and oxytocin, whose functions are linked to motivated social behaviors, are expressed in larvae at around 5 days post-fertilization (Herget et al, 2014; Caldwell and Albers, 2015). Intriguingly, around this stage, larvae begin to express olfactory guided social recognition, hinting at the possible functional involvement of these neuropeptides (Gerlach et al, 2008; Hinz et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

Motivated state control in larval zebrafish: behavioral paradigms and anatomical substrates

Horstick

Mueller

Burgess

2016

Journal of Neurogenetics

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Over the course of each day, animals prioritize different objectives. Immediate goals may reflect fluctuating internal homeostatic demands, prompting individuals to seek out energy supplies or warmth. At other times, the environment may present temporary challenges or opportunities. Homeostatic demands and environmental signals often elicit persistent changes in an animal’s behavior to meet needs and challenges over extended periods of time. These changes reflect the underlying motivational state of the animal. The larval zebrafish has been established as an effective genetically tractable vertebrate system to study neural circuits for sensory-motor reflexes. Fewer studies have exploited zebrafish to study brain circuits that control motivated behavior. In part this is because appropriate conceptual frameworks, anatomical knowledge, and behavioral paradigms are not yet well established. This review sketches a general conceptual framework for studying motivated state control in animal models, how this applies to larval zebrafish and the current knowledge on neuroanatomical substrates for state control in this model.

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Section: Introductionmentioning

confidence: 99%

Motivated state control in larval zebrafish: behavioral paradigms and anatomical substrates

Horstick

Mueller

Burgess

2016

Journal of Neurogenetics

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“…In addition to olfaction, many nonhuman species also rely upon visual signals for kin recognition [38]. Studies of zebrafish, for example, have shown that family-specific morphometry and pigmentation patterns are all influenced by MHC genotype [26]. These visual cues are useful signals for kin recognition in zebrafish [26].…”

Section: Discussionmentioning

confidence: 99%

Genetic similarity and facial cues for kin recognition in humans

Torosin

Ward

et al. 2020

Preprint

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Kin recognition is essential to the evolution of human cooperation, social organization, and altruistic behavior. However, the genetic underpinnings of kin recognition have been largely understudied. Facial resemblance is an important relatedness cue for humans and more closely related individuals are generally thought to share greater facial similarity. To evaluate the relationship between perceived self-resemblance and genetic similarity among biologically related and unrelated females, we administered facial self-recognition surveys to twenty-three sets of related females and genotyped three different genetic systems, human leukocyte antigens (HLA), neutral nuclear microsatellites and mitochondrial haplogroups, for each individual.Using these data, we examined the relationship between visual kin recognition and genetic similarity. We found that pairs of individuals identified as visually more similar had greater HLA allelic sharing when compared to less facially similar participants. We did not find the same relationship for microsatellite and mitochondrial similarity, suggesting that HLA allelic similarity increases the probability of perceived self-resemblance in humans while other genetic markers do not. Our results demonstrate that some genetic markers, such as HLA-DRB, may have significant influence on phenotype and that large scale surveys of HLA and facial feature morphology will yield valuable insight into the evolutionary biology of genotypephenotype relationships and kin recognition.

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“…Zebrafish larvae exposed to kin at day 5 and 6 days post-fertilisation recognise each other throughout their life, due to a combination of visual and olfactory imprinting. This process involves the major histocompatibility complex (MHC) code, which influences the chemical and visual features that zebrafish display [37]. Zebrafish appear to only imprint upon kin expressing similar MHC class II genes, and this process is likely olfactory based, because MHC peptides can activate a subset of neurons in the olfactory bulb [38 ].…”

Section: Social Behaviourmentioning

confidence: 99%